Long-term use of over-the-counter painkillers is leading to kidney damage among people, doctors here have warned ahead of World Kidney Day.
World Kidney Day is a global campaign observed annually on March 10. It is aimed at raising awareness about the importance of our kidneys.
Many painkillers are sold without a prescription for reducing pain and inflammation. These include Non-steroidal Anti-inflammatory Drugs (NSAIDs) such as ibuprofen, diclofenac and naproxen.
A combination of drugs, including aspirin, acetaminophen and caffeine, are also easily available and commonly taken by patients for chronic headaches and backaches.
"Not many people realise it, but long-term use of analgesics (painkillers) can lead to a condition called analgesic neuropathy which causes kidney damage. Painkillers don't harm the kidneys in healthy individuals if taken occasionally.
However, taking them too often for a prolonged period, especially as a combination of drugs, can cause severe kidney damage," Dr. Manju Aggarwal, Chief - Medical Services & Chairperson - Nephrology at Artemis Hospital, Gurugram.
Aggarwal added that the threat is even greater in high-risk individuals such as the elderly, diabetics and patients of high blood pressure. Their kidneys can get damaged with even occasional use of painkillers, she noted.
Painkillers lead to kidney damage in many ways, including acute rise in creatinine levels, known as Acute kidney Injury.
There can also be worsening of pre-existing Chronic Kidney Disease in terms of rise in creatinine levels.
Painkillers can also cause a rise in potassium levels in the body. Most patients remain asymptomatic in early stages of kidney disease and the raised creatinine is an incidental finding.
However, in advanced forms of the disease, there can be breathlessness, vomiting, loss of appetite and swelling all over the body.
The doctor said that prevention is always better than cure, so a judicious use of painkillers is advised. These should be taken if absolutely necessary.
"Patients with known kidney disease or those at risk of kidney disease such as the elderly and diabetics should avoid pain killers totally. They should instead switch to paracetamol or opioids for pain control," Aggarwal said.
"If you are taking painkillers regularly and find that your creatinine level is raised, discontinue their use and see a nephrologist immediately," he advised.
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"This is yet another milestone in our fight against Covid-19. Covovax is now WHO approved for emergency use, showing excellent safety and efficacy. Thank you all for a great collaboration," Serum Institute of India CEO Adar Poonawala said.
Covovax has a two-dose regimen and is the ninth to receive emergency use approval from the WHO. However, it is yet to be granted emergency use authorisation (EUA) by the top drug regulator, the DCGI, in India.
The listing aims to increase access particularly in lower-income countries, 41 of which have still not been able to vaccinate 10 per cent of their populations, while 98 countries have not reached 40 per cent, said the global health body.
Covovax was assessed under the WHO EUL procedure based on the review of data on quality, safety and efficacy, a risk management plan, programmatic suitability, and manufacturing site inspections carried out by the Drugs Controller General of India.
The Technical Advisory Group for Emergency Use Listing (TAG-EUL), convened by the WHO and made up of experts from around the world, has determined that the vaccine meets WHO standards for protection against Covid-19, that the benefit of the vaccine far outweighs any risks, and that the vaccine can be used globally, the WHO said in a statement.
The Covovax vaccine, developed by the SII in partnership with the US-based Novavax, is the third India-related vaccines to be approved by the WHO. The other two vaccines are Covishield and Covaxin. Covaxin is India's first indigenous Covid vaccines, while Covishield is Indian version of Britain's AstraZeneca jab.
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आयुष मंत्रालयाने यासाठी तज्ञ गटाची स्थापना करून एएसयू (आयुर्वेद, सिद्ध आणि युनानी) औषधांमध्ये अश्वगंधा (विथानिया सोम्निफेरल) पानांच्या वापराशी संबंधित प्रकरणाची पुन्हा तपासणी करण्याचा निर्णय घेतला आहे.
यापूर्वी, मंत्रालयाने ASU औषधांमध्ये अश्वगंधाच्या पानांच्या वापराविरोधात मार्गदर्शक तत्वे जारी केली होती.
आयुष मंत्रालयाने अश्वगंधा पानांचा वापर प्रतिबंधित केल्याच्या पार्श्वभूमीवर एएसयू औषध निर्मण उद्योगांच्या भागीदारांकडून निवेदने प्राप्त झाली होती.
तसेच, आयुष मंत्रालयाने हितधारकांना एएसयू उत्पादनांमध्ये अश्वगंधाच्या पानांच्या वापराबाबत समस्यांवर चर्चा करण्यासाठी आमंत्रित केले होते. या चर्चेच्या आधारे, मंत्रालयाने तज्ज्ञ गट स्थापन करून अश्वगंधा (विथानिया सोम्निफेरा) पाने वापरण्यापासून परावृत्त करण्यासाठी औषध उत्पादकांना जारी केलेल्या मार्गदर्शक तत्वे पुन्हा तपासून पाहण्याचा निर्णय घेतला आहे.
वैज्ञानिक पुराव्याच्या आधारे एएसयू उत्पादनांमध्ये अश्वगंधाची पाने/अश्वगंधाच्या पंचांगाच्या वापराबाबत तज्ञ गट सरकारला योग्य शिफारसी करेल.
पुढे वाचा► आयुष-64 ची मागणी आता सहज पूर्ण होणार; सीसीआरएएस ने 46 कंपन्यांना तंत्रज्ञान हस्तांतरित केले
The Ministry of Ayush has decided to re-examine the matter relating to the use of Ashwagandha (Withania somniferal) leaves in ASU (Ayurveda, Siddha and Unani) drugs by constituting an expert group to this end.
Earlier, the ministry had issued an Advisory against using the leaves of Ashwagandha in ASU Drugs.
In the wake of Ayush Ministry barring the use of Ashwagandha leaves (vide letter No. L-11011/9/2021-DCC dated 06.10.2021 to the ASU Drugs Manufacturing Association), representations had been received from the ASU Drugs Manufacturing Industry partners.
Also, the Ministry of Ayush had invited the stakeholders to discuss their concerns about the utilization of Ashwagandha leaves in ASU products. Based on this discussion, the ministry has decided to re-examine the advisory issued to the drug manufacturers to refrain from using Ashwagandha (Withania somnifera) leaves by setting up an Expert Group.
The Expert Group will make appropriate recommendations to the Government of India on the use of Ashwagandha leaves/Panchanga of Ashwagandha in ASU products based on scientific evidence.
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Pregnancy is a beautiful experience during which a woman nurtures and grows a baby for a period of 9 months. During this time, the body experiences many changes both internally and externally as it turns into a space of nourishment and protection for the growing foetus.
Hormonal fluctuations, stretching of the skin, greater storage of fats, etc can also lead to significant and apparent changes in the skin. While many women often feel self-conscious and mourn the loss of their pre-pregnancy skin, it is important to know that these changes are completely normal and that many women feel the way you do! These issues can be managed during pregnancy and also minimised post-pregnancy.
Avoid comparing how your body reacts to pregnancy as it largely depends on factors beyond your control such as your genetics. Having said that, below are some of the most common skin issues that women face during and post-pregnancy with some simple steps that one can take to manage them-
Often known as "the mask of pregnancy," is a pigmentation disorder that is caused by a combination of hereditary, hormonal factors, as well as due to sun exposure. It shows up as mottled dark spots on the cheekbones, forehead, nasal bridge, upper lips and rarely, over the jawline.
How to Tackle It:
a) Sun protection is the most important step to avoid and prevent the worsening of melasma. Physical protection like opaque umbrellas, wide-rimmed hats, the scarf should be used while stepping out in the sun
b) Use liberal amounts of sunscreen with a minimum SPF 30, in the morning, at least 15 minutes before stepping out and repeat it in the afternoon after 3-4 hours. Sunscreen use should not be restricted to only while stepping outdoors or when it's sunny but also while indoors. Remember to use only physical sunscreen during your pregnancy and breastfeeding period.
c) Using skin lightening products that contain kojic acid, glycolic acid and vitamins C, E, and A in lower concentrations can assist to brighten and rejuvenate your complexion.
Stretch marks affect around 90 percent of women at some point in their life, with pregnancy being one of the most prevalent times when this occurs. These marks, reddish-purple scars become white over time and are produced by the damage to its elastic fibres when it is stretched due to weight increase. These are particularly noticeable on the abdomen after delivery.
How to Tackle It:
a) Prevention is better than cure. Start using moisturising lotions containing cocoa butter and Shea Butter during pregnancy itself and continue to post your delivery.
b) Massages will also enhance the elasticity of the skin, however, do take care to do it gently.
c) In the initial stages, the stretch marks are red in colour (striae rubra) and these respond best to treatment, so do visit your dermatologist early.
d) Various cosmetic procedures like lasers, PRP, micro-needling with a derma roller can be done to lighten the scars.
Acne or pimples is caused by an inflammation of the sebaceous glands of the face. While a few women report clearing of their pre-existing acne during pregnancy, others may experience a severe flare. This is due to the hormonal changes that occur during pregnancy.
How to Tackle It:
a) Always use cosmetics that are non-comedogenic.
b) Increased fluid intake and staying hydrated may help your acne naturally.
c) Remember to remove makeup before bedtime and avoid frequently touching your face.
d) Products containing benzoyl peroxide may be used to penetrate clogged pores and remove pollutants; it is also safe to use during and after breastfeeding.
e) Although products containing retinol are great for acne treatment, they are contraindicated during pregnancy and breastfeeding.
Eczema, also known as dermatitis, is a common yet non-infectious skin condition that will not transmit to the infant. It's usually the result of an underlying sensitive skin disease that's been there for a while. Hand eczema has become quite common of late due to frequent hand washing with harsh soaps and hand sanitisers.
How to Tackle It:
a) Use a mild soap with a skin-friendly pH.
b) Gently pat dry the skin after each wash and apply a moisturising cream immediately which helps to lock in the moisture content of the skin.
c) Topical steroid creams are used to treat severe eczemas, however, they should always be prescribed by a dermatologist after careful evaluation and never be taken OTC from pharmacies. They are safe during pregnancy and lactation.
d) Do not wear anything too tight or shape-fitting. Tight clothes may trap the heat and make the skin irritable. Better to pick natural fabrics, like cotton.
The most common pregnancy rash is PUPPPs, or pruritic urticarial papules and plaques of pregnancy. These itchy, red spots appear around stretch marks and can spread to the arms, legs, and buttocks. They generally appear at the end of pregnancy, when the tummy is stretched the most.
How to Tackle It:
a) Try applying something cold to your rash to receive some relief. Apply an ice pack for 15 to 20 minutes or cover the rash with a cold, damp cloth.
b) Have lukewarm water baths as very hot water dries the skin and aggravates the itching
c) Keep the skin moisturised with a good moisturiser or coconut oil.
d) Visit your dermatologist who will further guide you on use of safe treatment options during pregnancy and lactation.(Dr. Swathi Shivakumar, Consultant Dermatologist, Aster RV Hospital, JP Nagar, Bengaluru)
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Ministry of Ayush has recently noticed safety concerns on use of Guduchi (Tinospora cordifolia) that were published in social media and in some scientific journals.
This advisory is being issued to confirm that Guduchi (Tinospora cordifolia) is safe to use but some similar looking plants like Tinospora crispa may be harmful. Guduchi is a popularly known herb, familiar as Giloy and is being used in therapeutics since long in AYUSH systems.
There are good number of studies published in peer reviewed indexed Journals to substantiate safety and efficacy of Guduchi (Tinospora cordifolia). Its hepato-protective properties are also well established. Guduchi is known for its immense therapeutic applications and the practices are regulated in accordance with various applicable provisions.
It is observed that different species of Tinospora are available and only Tinospora cordifolia should be used in therapeutics, whereas similar looking species like Tinospora crispa may manifest adverse effects.
Ministry of Ayush has a well-established system of Pharmacovigilance (for reporting of suspected adverse drug reactions from Ayush medication), with its network spreading across all over India. If any suspected adverse event occurs after intake of Ayush medicine it may be reported to the nearby Pharmacovigilance centre through an Ayush physician. Further it is advised to take Ayush medicine and treatment under supervision and consultation of a registered Ayush physician only. (PIB)
Guidelines issued by Ministry of Ayush-
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