New York, Aug 20 (IANS) Several drugs that are already in use for other purposes, including one dietary supplement, have shown to block or reduce infection by SARS-CoV2, the virus causing Covid-19, in cells, researchers have found.The study, published in the Proceedings of the National Academy of Science, uses artificial intelligence-powered image analysis of human cell lines during infection with the novel coronavirus.The cells were treated with more than 1,400 individual US Food and Drug Administration-approved drugs and compounds, either before or after viral infection, and screened, resulting in 17 potential hits.Ten of those hits were newly recognised, with seven identified in previous drug repurposing studies, including remdesivir, which is one of the few FDA-approved therapies for Covid-19 in hospitalised patients."Traditionally, the drug development process takes a decade -- and we just don't have a decade," said Jonathan Sexton, Assistant Professor of Internal Medicine at the University of Michigan Medical School."The therapies we discovered are well positioned for phase 2 clinical trials because their safety has already been established," he added.The team validated the 17 candidate compounds in several types of cells, including stem-cell derived human lung cells in an effort to mimic SARS-CoV2 infection of the respiratory tract.Nine showed antiviral activity at reasonable doses, including lactoferrin, a protein found in human breast milk that is also available over the counter as a dietary supplement derived from cow's milk."We found lactoferrin had remarkable efficacy for preventing infection, working better than anything else we observed," Sexton said. He added that early data suggest this efficacy extends even to newer variants of SARS-CoV2, including the highly transmissible Delta variant.The team aims to soon launch clinical trials of the compound to examine its ability to reduce viral loads and inflammation in patients with SARS-CoV2 infection.The study also identified a class of compounds called MEK-inhibitors, typically prescribed to treat cancer, that appear to worsen SARS-CoV2 infection. The finding sheds light on how the virus spreads among cells."People going in for chemotherapy are at risk already due to a lowered immune response. We need to investigate whether some of these drugs worsen disease progression," said Sexton.--IANSrvt/ksk/
New York, July 31 (IANS) A team of researchers has leveraged two new molecules, one of which is currently in clinical oncology trials, to devise a dual-drug therapy for alcohol use disorder (AUD), without the side-effects or complications associated with current treatment regimens.The study, published in the journal Nature Communications, indicates that the approach had highly successful results in mice and may apply to other drugs that are often abused."Alcohol use disorder is really a process of maladapted learning and memory," said researcher Dorit Ron from the University of California, San Francisco."Alcohol is rewarding, and we learn to associate alcohol, and even the environment in which we drink the alcohol, with that reward," Ron added.At the root of the team's thinking is the idea that AUD and other substance abuse disorders are the results of reinforced pathways in the brain, and that those pathways can be blocked or redirected, ending cravings and habitual behaviour.The researcher said she is studying the role of the enzyme mTORC1 in the creation of those memories and associations, to create an effective drug that can treat the neurological causes of AUD.Ordinarily, mTORC1 is involved in brain plasticity, helping to create connections between neurons that reinforce memory. In previous work, Ron showed that consuming alcohol activates the enzyme in the brain.Ron has also shown that blocking the activity of mTORC1 with the FDA-approved compound rapamycin, used to treat some types of cancer and suppress the immune response in transplant patients, can halt cravings in mice engineered for alcohol use disorder.But mTORC1 contributes to a bevy of other bodily tasks related to metabolism and liver function, and people taking it for an extended period often develop liver toxicity, glucose intolerance, and other side effects.Ron believes that tackling addiction from a neurological perspective has potential for broad applications."We could see these side effects in mice who are taking rapamycin or RapaLink-1, and then when you give Rapablock, it's like magic, the side effects are gone," Ron noted.--IANSvc/arm
न्यूयॉर्क। टेस्टोस्टेरोन की खुराक लेने से ऐसे पुरुषों में दिल के दौरे और स्ट्रोक में काफी कमी आती है, जिनमें हार्मोन का स्तर अस्वाभाविक रूप से कम होता है। एक नए शोध में यह पता चला है।
यूरोपियन एसोसिएशन ऑफ यूरोलॉजी कांग्रेस में प्रस्तुत शोध के निष्कर्ष ने संकेत दिया कि टेस्टोस्टेरोन थेरेपी से पुरुषों के स्वास्थ्य में भी अन्य उपायों से अधिक सुधार देखा गया।
शोध निष्कर्ष के मुताबिक, मरीजों ने अपना वजन कम किया। उनमें नई मांसपेशियों का निर्माण हुआ, उनके कोलेस्ट्रॉल के स्तर और यकृत के कार्य में सुधार हुआ, उनका मधुमेह बेहतर ढंग से नियंत्रित हुआ और उनका रक्तचाप भी कम हो गया।
कहा गया है कि पुरुषों को कुछ मनोवैज्ञानिक और जैविक कार्यो के लिए टेस्टोस्टेरोन की जरूरत होती है। केवल निम्न कोलेस्ट्रॉल स्तर वाले लोग जो अन्य लक्षण प्रदर्शित करते हैं, उनमें टेस्टोस्टेरोन थेरेपी से लाभान्वित होने की संभावना अधिक रहती है।
शोध के निष्कर्ष में कहा गया है, उन लोगों के लिए जो दिल के दौरे और स्ट्रोक के उच्च जोखिम में हैं, जिनमें टेस्टोस्टेरोन की कमी है, यह संभावना है कि हार्मोन को सामान्य स्तर पर वापस लाने से उन्हें अपने समग्र स्वास्थ्य में सुधार के लिए आवश्यक अन्य कदमों के लाभों को अधिकतम करने में मदद मिलती है।
अध्ययन के लिए, टीम ने टेस्टोस्टेरोन की कमी वाले 800 से अधिक पुरुषों को शामिल किया, जिनके पारिवारिक इतिहास, रक्तचाप, कोलेस्ट्रॉल के स्तर, मधुमेह या वजन ने उन्हें दिल के दौरे या स्ट्रोक के उच्च जोखिम में डाल दिया।
केवल सामान्य से नीचे टेस्टोस्टेरोन के स्तर वाले पुरुष, जिन्होंने कम टेस्टोस्टेरोन के लक्षण भी प्रदर्शित किए, जैसे कि खराब मूड, भूख में कमी, अवसाद, स्तंभन दोष, कामेच्छा में कमी या वजन बढ़ना, अनुसंधान में शामिल थे।
आधे से अधिक पुरुषों ने लंबे समय तक टेस्टोस्टेरोन रिप्लेसमेंट थेरेपी का विकल्प चुना, जिससे शोधकर्ताओं ने इस समूह की तुलना उन लोगों से की, जिनकी स्थिति का इलाज नहीं किया गया था।
सभी पुरुषों को अपने हृदय स्वास्थ्य में सुधार के लिए आहार, शराब, धूम्रपान और व्यायाम के मामले में जीवनशैली में बदलाव करने के लिए प्रोत्साहित किया गया।
शोध में कहा गया है कि टेस्टोस्टेरोन थेरेपी पर 412 पुरुषों में से 16 की मौत हो गई और किसी को भी दिल का दौरा या स्ट्रोक नहीं हुआ।
टेस्टोस्टेरोन की खुराक नहीं लेने वाले 393 पुरुषों में से 74 की मृत्यु हो गई, 70 को दिल का दौरा पड़ा और 59 को स्ट्रोक हुआ। (आईएएनएस)
यह भी पढ़े ► ह्दयरोग, कैंसर, स्ट्रोक आदि रोगों में हर्बल दवाएं ज्यादा बेहतर और प्रभावी
New York, Supplementing testosterone significantly reduces heart attacks and strokes in men with unnaturally low levels of the hormone, a new study suggests.
The study, presented at the European Association of Urology Congress, indicated that the health of the men on testosterone therapy also improved by other measures.
They lost weight, had more lean muscle mass, their cholesterol level and liver function improved, their diabetes was better controlled and their blood pressure dropped.
"While men need testosterone for certain psychological and biological functions, only those with low levels who display other symptoms are likely to benefit from testosterone therapy.
"For those at high risk of heart attack and stroke, who are deficient in testosterone, it's likely that bringing the hormone back to normal levels helps them to maximise the benefits of other steps necessary to improve their overall health," the study said.
For the study, the team included over 800 men with testosterone deficiency, whose family history, blood pressure, cholesterol levels, diabetes or weight put them at high risk of heart attack or stroke.
Only men with testosterone levels below normal, who also displayed symptoms of low testosterone, such as low mood, decreased appetite, depression, erectile dysfunction, loss of libido or weight gain, were included in the research.
Just over half of the men opted for long-term testosterone replacement therapy, enabling the researchers to compare this group to those whose condition was left untreated.
All the men were encouraged to make lifestyle changes, in terms of diet, alcohol, smoking and exercise, to improve their cardiovascular health.
Of 412 men on testosterone therapy, 16 died and none suffered a heart attack or stroke, the study said.
Of the 393 men who chose not to take testosterone supplements, 74 died, 70 had a heart attack and 59 suffered a stroke.(IANS)
London, July 7 (IANS) Men with symptomatic Covid-19 and low testosterone are six times more likely to become severely ill and die from the disease, new research has shown.
The study, conducted by researchers at San Raffaele University Hospital in Milan, Italy, found that the lower the levels of testosterone, the higher the likelihood that male patients would need intensive care, be intubated on a ventilator and remain in hospital over a longer period.
For the study, the team compared 286 male Covid patients, who came to the emergency department, with 305 healthy male volunteers between February and May 2020.
Nearly 90 per cent of the patients had testosterone below 9.2 nanomoles per litre (nmol/l), compared to just 17 per cent of the healthy volunteers. Those with testosterone levels between 3-4 nmol/l and had mild symptoms or were admitted to hospital, while those admitted to ICU or died of the disease had just 0.7-1.0 nmol/l.
"At the start of the Covid pandemic, we were seeing far more men than women coming to hospital and suffering very severe forms of the disease. We immediately thought this might be related to male hormone levels, particularly testosterone," Professor Andrea Salonia, a specialist in urology and endocrinology at the hospital.
"But we never expected to see such a high proportion of Covid patients with these extremely low levels of testosterone, in comparison to a similar group of healthy men. The relationship is very clear: the lower the testosterone, the higher the severity of the condition and likelihood of death. I've never seen anything like it in my 25 years in the field," Salonia added.
However, since the team does not have data on the testosterone levels in the patients before they contracted Covid-19, they cannot say whether low testosterone was a pre-existing long-term condition that exacerbated the disease or whether it was caused by the SARS-COV2 virus.
"Testosterone does play a role in protecting men from disease. However, it's also possible that the virus itself is able to induce an acute reduction in testosterone levels, which then predisposes these men to a worse outcome," Salonia said.
The findings will be presented at the 2021 European Association of Urology congress (EAU21), which starts from July 8-12.
Read More ► Higher testosterone levels ups diabetes risk in women
While it may sound weird to tell people with depression to go outside and garden, there is a considerable amount of clinical evidence which suggests that spending time with plants improves our mental health, particularly depression. Even spending time with indoor plants works wonders to alleviate both mental and physical stress in people of all ages.
Vinayak Garg, Founder, Lazy Gardener says: "Many researchers have found that gardening or ï¿½green care' stimulates our bodies' natural development of happy chemicals, which may help keep depression and anxiety at bay, with unexpectedly amazing results. Even during this pandemic, each nation is battling a war where the enemy is not visible nor are the weapons. In these times, along with other safety measures, why not turn to the potential benefits of gardening as a way to help in the mental and physical war against coronavirus."
Also, Read► How To Incorporate Exercise In Your Inactive WFH Day
Here are some interesting and the creative way to fight depression and anxiety, suggested by Garg.
Getting Your Hands Dirty!
Getting your hands dirty in the garden boosts your serotonin levels, according to studies. Serotonin is a happy chemical that also serves as a natural antidepressant and immune system booster, lack of which is responsible for depression. When you come in contact with soil, a particular soil bacterium, Mycobacterium vaccae, causes serotonin to be released in our brain, making us feel better and happier from within. At the very least, now we understand why people prefer to garden without gloves and always enjoy the sensation of getting their hands into the dirt and compost heap.
De-Stress Therapy at Your Doorstep
Gardening is an awesome diversion from our increasingly technologically driven lives. Spending time gardening and enjoying nature can help us mentally de-stress by keeping us involved. When you directly contribute to the nurturing of the buds and witness the plants grow gradually, believe me, your happiness and contentment will know no boundaries and you'll keep coming back to it. This is a small yet a very powerful exercise to even boost your self-esteem, leaving no space for stress at all.
Building Your Creativity
How about simply finding out how to keep those garden pests away and improving soil quality to keep the garden healthy? How about deciding what kind and colour of a pot will suit your favourite plant the best? Get yourself into it once and this green care will take care of your positivity, creativity, mood upliftment, skill building, and ultimately help you fight depression naturally and gradually.
Building Your Strength
Working in the garden improves dexterity and strength. Digging, raking, and mowing are especially calorie-dense activities and the aerobic exercise involved will easily burn the same amount of calories as a gym workout. During gardening, physical exercise is combined with social contact. You get exposed to nature and sunlight. Sunlight works two way on your body: reduces blood pressure while also increasing vitamin D levels, and the fruits and vegetables grown have a positive effect on the diet. Sounds healthier right?
Read More► Can Lack of Nutrients Cause Behavioural Changes?