Many people believe that heart disease typically affects men. Unfortunately, this is far from the truth. Coronary heart disease is the leading cause of mortality not only among men, but also among women. But women are actually at greater risk if not detected early, and this exacerbates the issue.
Signs of poor heart health do not appear as visibly in women as it does in men. What this means is that if a man has a heart issue, there are specific symptoms like angina which can be spotted easily and the right course of action be recommended. The same issue in a woman may not result in a sign or symptom that can be easily spotted. So often, their symptoms go ignored or unrecognised and they do not receive timely intervention to correct the problem. The issue is so acute that today 1 in 3 deaths among women is due to coronary heart disease.
There is also a significant lack of self-awareness among women about risk factors and the prevention of CVDs. Women don't only attend to matters of the home, but they hold positions at leading companies, and continue to rise to the occasion and meet impossible demands on their time. Through all of this, they take care of the emotional needs of their family members and loved ones; and still culturally are predisposed to putting the needs of others before their own. The stress they experience, among other common risk factors, often goes unnoticed by those around them. And stress has a greater influence on CVD risk in women vs men. Along with stress, other factors like diet quantity and quality also have a greater influence on CVD risk in women vs men. Additionally, women are also impacted by female-specific risk factors for CVD like polycystic Ovarian syndrome PCOS, preeclampsia, pregnancy induced hypertension and gestational diabetes.
In such a situation where symptoms of a heart problem do not manifest visibly, it is extremely important for women to be aware of their own risk factors and adopt proactive measures to take care of their heart health. For example, one risk factor, stress has been linked to a greater intake of energy and nutrient-dense foods, mainly sources of sugar and fat, and to poor diet quality. Women can take simple steps like reducing unhealthy fats and products with high content of sugar and salt to improve the quality of their diet. Choose ingredients that are good for the heart, like oatmeal, wholegrains, fiber rich vegetables, blended oils with the right balance of fatty acids, legumes, soy products, and the like. Regular and consistent exercise, adequate sleep, and other such lifestyle modifications can help maintain heart health in the long term.
Furthermore with signs of poor heart health not manifesting visibly in women, it is crucial that they get regular health check-ups done to assess their risk proactively. Self-awareness and early identification of cardiovascular risk factors can lead to better prevention of CVD in women.
This World Heart Day, let's choose self-care. Get a simple heart check-up done and encourage other women in yourselves too, to get the same done. Take proactive steps for heart health today.
(By Brajesh Kunwar)
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London- A team of researchers has discovered that the more severely a mother is infected with Covid-19, the more likely she is to experience preterm birth.
The researchers reported that the rate of preterm birth in nearly 1,000 pregnant women, who tested positive for SARS-CoV-2, the virus that causes Covid-19, was a function of the severity of infection.
"The more severe the SARS-CoV-2 infection, the greater the risk of preterm birth," said researcher Roberto Romero from the Wayne State University School of Medicine in the US.
"There was a dose-dependent relationship between the severity of SARS-CoV-2 infection and the risk of prematurity," Romero added.
For the study published in the American Journal of Obstetrics and Gynecology, the team included data from 14 National Health Service (NHS) maternity hospitals in the UK to assess the effects of SARS-CoV-2 infection in pregnancy.
The excess rate of premature birth, they report, is largely due to medically-induced preterm birth brought about by concerns for health of the mother, such as preeclampsia.
Preterm birth, the leading cause of perinatal morbidity and mortality worldwide, is defined as one that occurs before 37 weeks of gestation.
Two-thirds of preterm births are due to the spontaneous onset of preterm labour. The remaining third is due to medical conditions that affect either the mother or the unborn baby that necessitate delivery.
The more severe the Covid-19 infection, the greater the risk of preeclampsia, a sudden increase in blood pressure after the 20th week of pregnancy.
The condition is responsible for 76,000 maternal deaths and more than 5,00,000 infant deaths every year.
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London- Researchers have identified an anti-viral gene that impacts the risk of both Alzheimer's disease and severe Covid-19.
A team from the University College London (UCL) estimated that one genetic variant of the OAS1 gene increases the risk of Alzheimer's disease by about 3-6 per cent in the population as a whole, while related variants on the same gene increase the likelihood of severe Covid-19 outcomes.
"While Alzheimer's is primarily characterised by harmful build-up of amyloid protein and tangles in the brain, there is also extensive inflammation in the brain that highlights the importance of the immune system in Alzheimer's. We have found that some of the same immune system changes can occur in both Alzheimer's disease and Covid-19," said lead author Dr Dervis Salih, from UCL's Queen Square Institute of Neurology and UK Dementia Research Institute.
"In patients with severe Covid-19 infection, there can also be inflammatory changes in the brain. Here we have identified a gene that can contribute to an exaggerated immune response to increase risks of both Alzheimer's and Covid-19," Salih added, in the paper published in the journal Brain.
To understand the gene's link to Alzheimer's, the team sequenced genetic data from 2,547 people, half of whom had the brain disorder.
They found that people with a particular variation, called rs1131454, of the OAS1 gene were more likely to have Alzheimer's disease, increasing carriers' baseline risk of Alzheimer's by an estimated 11-22 per cent.
The new variant identified is common, and it has a bigger impact on Alzheimer's risk than several known risk genes, the researchers said.
Further, the researchers investigated four variants on the OAS1 gene, all of which dampen its expression (activity).
They found that the variants increasing the risk of Alzheimer's are linked (inherited together) with OAS1 variants recently found to increase the baseline risk of needing intensive care for Covid-19 by as much as 20 per cent.
That is, the microglia cells where OAS1 gene was expressed more weakly had an exaggerated response to tissue damage, unleashing what they call a 'cytokine storm,' which leads to an autoimmune state where the body attacks itself, the team said.
OAS1 activity changes with age, so further research into the genetic network could help to understand why older people are more vulnerable to Alzheimer's, Covid-19, and other related diseases, they added.
Read More► Why Covid-19 is More Deadly for Some With Diabetes
Our heart is the key organ in the circulatory system pumping oxygenated blood to various organs. People mostly ignore or are not aware of the symptoms of an approaching heart attack or cardiac ailment. With an increasing prevalence of a sedentary lifestyle, monitoring heart health becomes even more essential. Hence, one should be aware of the newly observed symptoms and complications that signal towards an unhealthy heart.
Chest Pain is Just One of The Many Overlooked Signs
Chest pain is one of the most common signs of an approaching cardiac ailment. Uncomfortable pressure, squeezing, fullness, burning, tightness, or pain in the centre of the chest should be reported to the doctor. Many times these symptoms are confused with gastritis and heartburn.
Snoring and interrupted sleeping patterns
Snoring and sleep-related problems like insomnia and sleep apnea, a disorder where breathing get disrupted while you sleep, have a direct link with heart diseases and other cardiovascular ailments.
Shortness of Breath
Unexplained shortness of breath while doing small amounts of physical activity, at rest or while sleeping (that can wake you up) may indicate an underlying cardiac ailment. Women are more likely to suffer/report shortness of breath when dealing with heart troubles.
Waking up tired, restless and noting higher blood pressure levels in the morning, signals towards an unhealthy heart. Though, one should get a clinical assessment done for ensuring a clear diagnosis.
Sweeting more than usual or without any physical activity, especially if one is not exercising or being active can be an early warning sign of an approaching heart-related ailment. If someone is sitting and suddenly starts sweating profusely, it could be a sign of an oncoming heart attack.
An irregular heartbeat or more formally known as "arrhythmias", is a condition where the heart doesn't pump blood at its normal rhythm. Anyone who is relatively healthy and still has an irregular heartbeat, also indicate a chronic heart condition.
Pain in the chest and upper arm area is what most people typically associate with heart problems. However, pain in the neck or jaw is a potential point of angina pain or discomfort when the heart lacks oxygen-rich blood. Women are more likely to exhibit these symptoms than men, but if the symptoms persist it is advisable to consult a doctor.
A persistent cough is not always a sign of a heart problem, as it's a common symptom of various other common illnesses like cold, flu, and bronchitis. But a never-ending cough can be a sign of fluid building up in the lungs, which signals congestive heart failure.
When the heart isn't able to pump efficiently, blood can back up into the veins that take blood through the lungs. When there is excessive pressure in these blood vessels, fluid is pushed into the air spaces (alveoli) in the lungs. Hence, an unending cough can be caused by the irritation and fluid in the lungs, which is similar to what can cause shortness of breath.
With the current lifestyle patterns, it is very important to monitor your heart health. There can be various hidden symptoms contributing towards an unhealthy heart, hence a timely diagnosis and an active lifestyle should be given attention to. The above-mentioned symptoms can be a few of many symptoms denoting an approaching heart ailment, as a reason being aware towards your own health and consulting for timely clinical interventions become essentially important.
Read More► Why Young Indians More Vulnerable to Heart Attack?
इंडियन काउंसिल ऑफ मेडिकल रिसर्च (आईसीएमआर) द्वारा तैयार की गई एक रिपोर्ट में कहा गया है कि 2012-19 के बीच कैंसर के कुल मामलों में से 7.9 फीसदी 14 साल से कम उम्र के बच्चों में पाए गए। 'क्लिनिकोपैथोलॉजिकल प्रोफाइल ऑफ कैंसर्स इन इंडिया : ए रिपोर्ट ऑफ हॉस्पिटल-बेस्ड कैंसर रजिस्ट्रीज, 2021', नेशनल कैंसर रजिस्ट्री प्रोग्राम (एनसीआरपी) के तहत 96 अस्पताल-आधारित कैंसर रजिस्ट्रियों की अवधि के दौरान एकत्र किए गए डेटा को समेकित करता है। डेटा देशभर में इन केंद्रों को रिपोर्ट किए गए पुष्टिकृत विकृतियों के सभी निदान और इलाज के मामलों से संबंधित हैं।
देश में 2012-19 के दौरान कैंसर के 13,32,207 मामले दर्ज किए गए। इनमें से 6,10,084 को डेटा की पूर्णता और गुणवत्ता के आधार पर विश्लेषण के लिए शामिल किया गया था।
बचपन के कैंसर वैश्विक स्तर पर बचपन की बीमारियों के प्रमुख कारण के रूप में नौवें स्थान पर हैं, विकलांगता समायोजित जीवन वर्ष (डीएएलवाई) के 11.5 मिलियन के लिए जिम्मेदार है।
भारत में, एनसीआरपी की एक हालिया रिपोर्ट के अनुसार, सभी आयु समूहों में कैंसर के सापेक्ष बचपन के कैंसर (0-19 वर्ष) का अनुपात 1 से 4.9 प्रतिशत के बीच पाया गया।
दिल्ली में लड़कों में 203.1 प्रति मिलियन और लड़कियों में 125.4 प्रति मिलियन की उच्चतम आयु-समायोजित घटना दर (एएआर) दर्ज की। ल्यूकेमिया 0-14 वर्ष आयु वर्ग में दोनों लिंगों में सभी बचपन के कैंसर के लगभग आधे के लिए जिम्मेदार है (लड़कों में 46.4 प्रतिशत और लड़कियों में 44.3 प्रतिशत)। लड़कों में अन्य सामान्य बचपन का कैंसर लिम्फोमा (16.4 प्रतिशत) था, जबकि लड़कियों में यह घातक अस्थि ट्यूमर (8.9 प्रतिशत) था।
बचपन के कैंसर दो आयु समूहों के लिए प्रस्तुत किए जाते हैं : 0-14 वर्ष और 0-19 वर्ष राष्ट्रीय और अंतर्राष्ट्रीय तुलना को सक्षम करने के लिए और बचपन के कैंसर के अंतर्राष्ट्रीय वर्गीकरण के अनुसार वर्गीकृत किया जाता है।
रिपोर्ट में कहा गया है कि बचपन के कैंसर के अलावा, तंबाकू के उपयोग से जुड़े कैंसर में पुरुषों में 48.7 प्रतिशत और महिलाओं में 16.5 प्रतिशत कैंसर शामिल हैं।
थायरॉइड कैंसर (महिलाओं में 2.5 प्रतिशत बनाम पुरुषों में 1 प्रतिशत) और पित्ताशय के कैंसर (महिलाओं में 3.7 प्रतिशत बनाम पुरुषों में 2.2 प्रतिशत) को छोड़कर, साइट-विशिष्ट कैंसर का सापेक्ष अनुपात महिलाओं की तुलना में पुरुषों में अधिक था।
सभी कैंसरों में दूर के मेटास्टेसिस का उच्चतम अनुपात फेफड़ों के कैंसर (49.2 प्रतिशत पुरुष और 55.5 प्रतिशत महिलाओं) के रोगियों में देखा गया, इसके बाद पित्ताशय का कैंसर (40.9 प्रतिशत पुरुष और 45.7 प्रतिशत महिलाएं) और प्रोस्टेट कैंसर (42.9 प्रतिशत) का स्थान है।
रिपोर्ट ने सुझाव दिया कि कई कैंसर के लिए कीमोथेरेपी अभी भी सबसे विशिष्ट उपचार पद्धति थी, भले ही प्रस्तुति में रोग की नैदानिक सीमा कुछ भी हो, जिसमें यकृत, पित्ताशय, पेट, फेफड़े और बचपन के कैंसर शामिल हैं।
यह भी पढ़े► कैंसर और हार्ट अटैक से ज्यादा खतरनाक हो जाएगा सेप्सिस: शोध
Scientists at the Indian Institute of Science Education and Research (IISER) here have sequenced the genome of giloy a plant with medicinal properties, which shot to fame during the ongoing Covid-19 pandemic.
Giloy or guduchi is a climber with heart-shaped leaves, has major applications in pharmaceuticals and ayurvedic formulations to treat various health conditions and was used widely during the pandemic to boost immunity.Giloy (Tinospora cordifolia) is the first species ever sequenced from the Menispermaceae plant family, which comprises more than 400 species having therapeutic values, the institute said in a statement on Monday.
The availability of Giloy genome will also help in bridging the missing link between its genomic and medicinal properties. The new study will also provide leads for exploring the genomic basis of its medicinal properties, the team said.
The team performed a deep transcriptome sequencing of leaf tissue of the plant. The draft genome assembly had a size of 1.01 gigabase pairs and contained 19,474 coding gene sequences. The research is published in the preprint server bioRxiv.
"Giloy is considered as an important multipurpose medicinal plant in ayurvedic science. This plant came into the limelight due to its immunomodulatory and antiviral activity after the emergence of the Covid-19 pandemic. It has been used in various health conditions due to its immune-modulatory, antipyretic, anti-inflammatory, anti-diabetic, anti-microbial, anti-viral, anti-cancer properties, among others," said Shruti Mahajan, doctoral student at IISER Bhopal, in the statement.
Previous studies have shown that a compound from Giloy was reported to target the two proteases of SARS-CoV-2 virus namely Mpro and Spike proteases, and another compound was predicted to inhibit SARS-CoV-2 Mpro and also disrupts viral spike protein and host ACE-2 interaction. Treatment with giloy extract modulates the various pathways of the immune system for improved immunity.
These multiple medicinal properties are because of the presence of its secondary metabolites. Despite these medicinal properties, the unavailability of its genome sequence was a constraint in studying the genomic basis of the medicinal properties. Thus, the genome sequence of Giloy could be a breakthrough as the potential therapeutic agent for diseases like Covid in the future, the researchers said.
Moreover, the usage of giloy is also recommended under ayurveda practice by the Ministry of AYUSH and the Ministry of Health and Family Welfare, in prophylactic care as well as therapeutic applications for all symptomatic or asymptomatic patients infected with Covid-19. It is also used in fever and diabetes.
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