लंदन- यूरोपियन एसोसिएशन फॉर द स्टडी ऑफ डायबिटीज (ईएएसडी) की हालिया वार्षिक बैठक में टाइप 2 मधुमेह (टी2डी) से पीड़ित 100,000 से अधिक लोगों के एक अध्ययन के अनुसार, इंसुलिन प्रतिरोध स्ट्रोक से जुड़ा हुआ है। इंसुलिन प्रतिरोध तब होता है जब शरीर की कोशिकाएं इंसुलिन के लिए ठीक से कम नहीं करती हैं और आसानी से रक्त से ग्लूकोज नहीं ले पाती हैं। टी 2 डी की एक प्रमुख विशेषता और स्तर रोगी से रोगी में भिन्न होता है।
इंसुलिन प्रतिरोध जितना अधिक होगा, स्ट्रोक का खतरा उतना ही अधिक होगा। स्वीडन में करोलिंस्का इंस्टीट्यूट, गोथेनबर्ग विश्वविद्यालय और राष्ट्रीय मधुमेह रजिस्ट्री में एक संयुक्त टीम के नेतृत्व में किए गए अध्ययन से इसका खुलासा हुआ है।
टीम ने इंसुलिन प्रतिरोध के उपाय के रूप में अनुमानित ग्लूकोज (ईजीडीआर) का इस्तेमाल किया। ईजीडीआर को पहले इंसुलिन प्रतिरोध के लिए एक अच्छा प्रॉक्सी के रूप में दिखाया गया है।
स्वीडन में 104,697 टी2डी रोगियों के ईजीडीआर की गणना के लिए स्वास्थ्य रिकॉर्ड का उपयोग किया गया था। उनका औसतन 5.6 वर्षों तक पालन किया गया, जिसके दौरान 4,201 (4 प्रतिशत) को स्ट्रोक हुआ।
सबसे कम इंसुलिन प्रतिरोध (उच्चतम ईजीडीआर) वाले लोगों में उच्च इंसुलिन प्रतिरोध वाले लोगों की तुलना में स्ट्रोक होने की संभावना 40 प्रतिशत कम थी।
अध्ययन में यह भी पाया गया कि उच्च इंसुलिन प्रतिरोध स्ट्रोक के बाद मृत्यु के उच्च जोखिम से जुड़ा था। सबसे कम प्रतिरोध वाले लोगों की अनुवर्ती अवधि के दौरान सबसे गंभीर इंसुलिन प्रतिरोध वाले लोगों की तुलना में 28 प्रति कम मरने की संभावना थी।
करोलिंस्का इंस्टीट्यूट के अलेक्जेंडर जाबाला ने कहा, टाइप 2 मधुमेह वाले व्यक्तियों में, कम ईजीडीआर, इंसुलिन प्रतिरोध का एक सरल उपाय, स्ट्रोक और मृत्यु दर के बढ़ते जोखिम से जुड़ा है।
जाबाला ने कहा, ईजीडीआर का इस्तेमाल टी2डी रोगियों को स्ट्रोक और मौत के जोखिम को बेहतर ढंग से समझने और प्रबंधित करने में मदद के लिए किया जा सकता है।
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London- Insulin resistance is associated with stroke, according to a study of more than 100,000 people with Type 2 diabetes (T2D), presented at the recent annual meeting of the European Association for the Study of Diabetes (EASD).
Insulin resistance is when the body's cells don't respond properly to insulin and can't easily take up glucose from blood a key feature of T2D and levels vary from patient to patient.
The higher the insulin resistance, the greater the risk of stroke, revealed the study led by a joint team at the Karolinska Institute, Gothenburg University and the National Diabetes Registry in Sweden.
The team used the estimated glucose disposal rate (eGDR) as a measure of insulin resistance. eGDR has previously been shown to be a good proxy for insulin resistance and is calculated using a formula that factors in a patient's waist circumference, HbA1c (average blood sugar level) and whether they have high blood pressure.
Health records were used to calculate the eGDR of 104,697 T2D patients in Sweden. They were followed up for an average of 5.6 years, during which 4,201 (4 per cent) had a stroke.
Those with the lowest insulin resistance (the highest eGDR) were 40 per cent less likely to have a stroke than those with the highest insulin resistance.
The study also found that higher insulin resistance was linked to a higher risk of death after a stroke. Those with the lowest resistance were 28 per less likely to die during the follow-up period than those with the most severe insulin resistance.
Further analysis showed high blood pressure to be more strongly linked to stroke than waist circumference or HbA1c.
"We found that in individuals with type 2 diabetes, a low eGDR, a simple measure of insulin resistance, was associated with an increased risk of stroke and mortality," said Alexander Zabala from the Karolinska Institute.
"eGDR could be used to help T2D patients better understand and manage their risk of stroke and death," Zabala added. (agency)
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San Francisco, Sep 5 (IANS) Google is all set to collaborate with researchers to develop new artificial intelligence (AI) algorithms to improve brain stimulation devices to treat people with psychiatric illness and direct brain injuries, such as stroke.The tech giant has tied up with researchers at Mayo Clinic to develop a set of paradigms, or viewpoints, that simplify comparisons between effects of electrical stimulation on the brain.They developed a new type of algorithm called "basis profile curve identification"."Our findings show that this new type of algorithm may help us understand which brain regions directly interact with one another, which in turn may help guide placement of electrodes for stimulating devices to treat network brain diseases," said Kai Miller, a Mayo Clinic neurosurgeon."As new technology emerges, this type of algorithm may help us to better treat patients with epilepsy, movement disorders like Parkinson's disease, and psychiatric illnesses like obsessive compulsive disorder and depression," he added.The new technique was demonstrated for an array of implanted brain surface electrodes in a human patient. A patient with a brain tumour underwent placement of an electrocorticographic electrode array to locate seizures and map brain function before a tumour was removed.Every electrode interaction resulted in hundreds to thousands of time points to be studied using the new algorithm.The framework enables straightforward interpretation of single-pulse brain stimulation data, and can be applied generically to explore the diverse milieu of interactions that comprise the connectome, the researchers explained in the study published in PLOS Computational Biology."Neurologic data to date is perhaps the most challenging and exciting data to model for AI researchers," said Klaus-Robert Mueller, member of the Google Research Brain Team.--IANSrvt/vd
London, July 28 (IANS) Researchers have found that strokes were a common complication experienced by hospitalised adults with severe Covid-19, with higher rates than expected amongst younger people.The study, led by a team at the University of Southampton in the UK, showed that risk factors such as diabetes and high blood pressure, contributed to the risk of stroke, including in younger people.The study, published in the journal Brain Communications, looked into 267 cases of Covid-19 related neurological and psychiatric problems in the UK.Of the 267 cases, strokes were the most frequently reported conditions, affecting nearly half of the patients. Over a quarter of strokes occurred in patients under 60 years old, many of whom had modifiable risk factors that meant they were already at risk of stroke.Other common conditions included delirium, psychiatric events and other evidence of damage to the brain (encephalopathy). More than 10 per cent of patients experienced more than one neurological condition, and these patients were more likely to require intensive care and ventilation."It was striking not only how many different neurological and psychiatric events we observed in this study, but also that some of these conditions occurred together within the same patients. This suggests Covid can affect multiple parts of the nervous system in the same patient," said Dr Amy Ross-Russell, research fellow at the NIHR Southampton Clinical Research Facility at University Hospital Southampton NHS Foundation Trust."Patients with strokes also had blood vessel blockages or thrombosis elsewhere in the body so this is important for understanding why some strokes occur during Covid-19," Ross-Russell added.The finding suggests that Covid-19 amplifies the risk of stroke, including in younger people. Public health measures could reduce this, including lifestyle measures to avoid developing diabetes and high blood pressure, good control of blood sugar and blood pressure, and avoiding the risk of severe Covid-19 through vaccination and other public health measures.--IANSrvt/dpb
New York, Supplementing testosterone significantly reduces heart attacks and strokes in men with unnaturally low levels of the hormone, a new study suggests.
The study, presented at the European Association of Urology Congress, indicated that the health of the men on testosterone therapy also improved by other measures.
They lost weight, had more lean muscle mass, their cholesterol level and liver function improved, their diabetes was better controlled and their blood pressure dropped.
"While men need testosterone for certain psychological and biological functions, only those with low levels who display other symptoms are likely to benefit from testosterone therapy.
"For those at high risk of heart attack and stroke, who are deficient in testosterone, it's likely that bringing the hormone back to normal levels helps them to maximise the benefits of other steps necessary to improve their overall health," the study said.
For the study, the team included over 800 men with testosterone deficiency, whose family history, blood pressure, cholesterol levels, diabetes or weight put them at high risk of heart attack or stroke.
Only men with testosterone levels below normal, who also displayed symptoms of low testosterone, such as low mood, decreased appetite, depression, erectile dysfunction, loss of libido or weight gain, were included in the research.
Just over half of the men opted for long-term testosterone replacement therapy, enabling the researchers to compare this group to those whose condition was left untreated.
All the men were encouraged to make lifestyle changes, in terms of diet, alcohol, smoking and exercise, to improve their cardiovascular health.
Of 412 men on testosterone therapy, 16 died and none suffered a heart attack or stroke, the study said.
Of the 393 men who chose not to take testosterone supplements, 74 died, 70 had a heart attack and 59 suffered a stroke.(IANS)
Bengaluru, June 22 (IANS) About 12 cancer survivors from Bengaluru on Tuesday made an appeal to Prime Minister Narendra Modi and Karnataka Chief Minister B. S. Yediyurappa to take steps to impose a ban on tobacco sales, smoking, and spitting in public places which would help mitigate the spread of Covid-19 in the anticipated third wave and future waves.Besides appealing to Modi and Yediyurappa, these survivors have also sent copies of the letter to Union Health Minister Harsha Vardhan, Karnataka health minister, K. Sudhakar and Deputy chief minister, C. N. Ashwath Narayan, who is also the chairman of the Karnataka Covid Task Force.Citing the findings of the World Health Organisation (WHO), cancer survivors from the city in their letter dated June 22, said that smokers are at a high risk of developing severe complications when infected with the Covid-19 virus."Smokers are at a greater risk for hospital admission, need for ventilators, ICUs, and even death due to Covid-19. While chewing tobacco products increases saliva production and when the user spits it out, he/she spreads germs and viruses. Therefore, it is in the larger interest of the society that governments take stringent measures to ban sale of tobacco and its allied products," Nalini Satyanarayana,a cancer survivor and health activist, noted.She added that people who are nearby could inhale it (smoke) or touch the contaminated surface, getting infected and leading to the spread of the virus.The letter by these survivors asked both the state and Union governments to ban smoking at hotels, airports, pubs and hookah bars to prevent the spread of the virus."The governments must take steps to introduce vendor licensing to reduce accessibility of tobacco and its allied products. Besides this, the governments must also effectively implement a ban on public spitting, which will help in reducing the spread of deadly virus now and in future too," the survivors said in their letter.Meanwhile, oncologist Dr Vishal Rao, who is also a member of Karnataka's High Power Committee on Tobacco Control, highlighted that Covid-appropriate behaviour like wearing masks and social distancing cannot be followed in designated smoking areas (DSAs)."The current provisions of the Cigarette and Other Tobacco Products Act (COTPA) allows smoking in DSAs at restaurants, pubs, bars, and airports and these DSA are often very congested places where droplets can survive in such closed chambers with them having a possibility to become super-spreaders of Covid-19," he argued.The Consortium for Tobacco Free Karnataka's honorary advisor, Vijayalakshmi Balekundri, said the state should enforce the ban on spitting in public places, which is already imposed, by slapping fines on the violators."As the state is gradually unlocking, it is the right time for the government to consider banning DSAs and to amend COTPA," she said.--IANSnbh/bg