Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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In comparison to adults, children are prone to getting traumatized by troubling events easily, and this makes it important for parents to help their children when the times are tough. It could be a brutal accident, an unprecedented pandemic, a violent crime, or other disasters but with the right parental support, children have a higher chance of coming out stronger from an awful situation.
few tips wherein you can assist your child when tough times comes calling:
Every child responds differently to disturbing events: What children feel about a current disaster in their life and how they react to it can come and go in waves. Children can act moody and withdrawn at times, struck with sorrow and fear at other times. There's no absolute "right" or "wrong" way to feel after a traumatic event so make sure not to dictate what your child or how your child should feel and react to the event.
Encourage your child to be transparent: Just make sure you let your child know that whatever feelings they're experiencing is normal. The unpleasantness will pass if your child opens up about it and that the phase is temporary. While many teens may be reluctant to talk about their feelings with a parent, encourage them to confide in another trusted adult such as a family friend, relative, or a counsellor and teacher. It's important to talk even if it's not with you.
Deter your child from reliving the disturbing event: Dwelling over, watching the footage, or imagining the event can be overwhelmingly stressful for children and this stress can even block their nervous system. However, to negate such things from happening encourage activities that keep your child's mind occupied so they're not obsessive about the event. You could encourage your children to read, play games together, or simply watch an uplifting movie.
Cocoon your child with warmth: In order to reassure your child that they are safe with you and feel secure, that the worst is over your physical affection is important in making them feel safe again. Teens may try to be tough through it and avoid being held, but they still need proximity.
Maintain routines: Establishing a predictable structure and schedule for your child's life can help to make the world seem more stable again. Try to maintain regular times for meals, homework, and family activities. Make sure your child accommodates time and space for rest, play, and fun. Keeping up with a schedule can help countercheck the obnoxious feeling of stress and worry in children about the future being dark, hopeless, and unpredictable.
Acknowledge and validate your child's concerns: The disastrous events in life may give place to unrelated fright and concerns in your child. However, understanding and accepting your child's present state is a comfort for the child. If at any point the child blames himself for the event make sure to make it clear and crisp the event was not their fault, you love them, and it's okay for them to feel upset, angry, or scared but not guilty.
Irrespective of the age of your child: it is vital for parents to offer that extra support and assistance following an unsettling event. The traumatic event may bring up unrelated fears and issues in your child. However, by accepting their thoughts and replacing their fear with your love and direction, the ominous feelings will start to fade away. Eventually, the child will be able to return to a normal and healthy life.
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Many factors can contribute to your high stress levels, lack of sleep, and getting sick. But did you know that all three of these actually go hand-in-hand? Here's how stress, sleep, and immunity are linked when considering one's general well-being.
"Stress, sleep and immunity are closely linked. When you miss out on sleep, you miss out on time for your body to recharge and prepare for the next day. In fact, sleep is quite vital for our cardiovascular and immune systems to function properly, as well as our ability to think clearly, learn and retain new information, and manage our emotions.
If an individual continuously deprives themselves of getting enough sleep each night, they create more stress on their bodies physically and mentally, which in turn affects the immune system, and essentially creates a negative downward spiral," says Nora Tobin, performance enhancement and executive coach, nutrition specialist, and CEO of Nora's Naturals Coffee.
How can optimising stress, sleep and immunity improve your professional performance? Here's what she has to say:
"Other than a strong work ethic and a high level of drive, your professional performance too, is connected to your overall health and well-being. Practicing healthy habits such as getting consistent sleep and managing your stress, can help you stay healthy and maintain a strong immune system. When you get into a healthy routine you will feel more productive and ready to produce high-quality results that you wish to see in your professional life."
Here are Tobin's top 3 tips for optimising stress, sleep, and immunity:
Result of Stress: When the body is under chronic mental or physical stress, the production of cortisol becomes unbalanced. This leads to excessive fatigue, brain fog, and the storage of fat in the abdominal region. In order to produce enough cortisol to keep going throughout the day, the body pulls from the thyroid (lowered metabolism).
The Solution to Stress: Guided breathing, vitamin D and adaptogenic herbs balance cortisol (stress hormone) as well as regulates the amygdala part of your brain that controls anxiety. Try to incorporate one or all of the below daily.
1-minute Meditation: take an inhale for 3 counts, hold your breath at the top for 3 and exhale for 3. Repeat for 1-minute.
Vitamin D: The precursor to serotonin (a feel-good hormone) and strong immune defence for the body. Get outside for 10 minutes without sunglasses or try this quality source of Vitamin D daily.
Herbs: Adaptogenic Herbs have been utilised in India for thousands of years and help support the body's energy and naturally protect against cellular stress. The top two herbs to utilise to lower stress and anxiety are Reishi and Ashwagandha. Mix into tea or water before bed.
Result of Sleep: During sleep, cerebral spinal fluid runs through the brain to clear toxins and create new neural connections crucial for retaining information and slowing down aging. This process is called glymphatic drainage. The lymphatic system primarily works during sleep so to successfully create new cerebral pathways and clear waste products, it is essential to get at least six hours of sleep.
A solution to Sleep: Legs up the wall, temperature changes and minerals help the body shift into a parasympathetic nervous system (rest and digest) and out of flight or fight mode.
Legs up the Wall: Lying for 5-10 minutes with legs up the wall will reset circadian rhythm and improve the body's ability to drop into deep REM sleep. Simply lie with legs resting on the wall with feet above hips taking deep breaths.
Change Temperatures: Alternating between hot water and cold in the shower (20 seconds hot, 10 cold) for two minutes before bed will greatly improve the body's natural ability to regulate its own production of melatonin.
Result of Low Energy: The body has two forms of energy-burning -- glucose and ketones. When the body is primarily burning glucose, it goes through rapid spikes in blood sugar, leading to cravings, energy crashes and weight gain. When the body is burning ketones, it's receiving steady-state energy while burning its own fat stores.
Solution to Sustained Energy: Interval workouts, whole foods and eating healthy fat allow the body to burn more ketones for energy without feeling deprived. This leads to rapid cellular turnover, efficient weight loss/management, and high energy levels all day long.
High Intensity Interval Training: Raises post workout oxygen consumption, elevating metabolism for 24 hours post-workout. The form of training is suitable for all levels, takes less than 20 minutes, and requires no equipment. This allows the body to burn fat much more efficiently and supply adequate energy to the brain. Alternate with days of low-intensity training like yoga or walking.
Increase Anti Inflammatory Foods: Lowering inflammation in the body will optimise and help sustain energy throughout the day, help fight off pathogens and generate rapid cellular turnover. Pick any foods from the attached list to incorporate daily as well as spices and herbs (the more the better).
Incorporate the 8-Hour Eating Window: Shortening the time window of our meals increases autophagy and allows the body to burn ketones (fat stores) for fuel instead of glucose. Eating in this window a few days per week will rapidly increase cellular turnover, boost irisin and enhance cognitive function.
Read More► All You Need to Know About a Cellular Detox And Cleansing
New Delhi, Aug 20 (IANS) A survey highlighted that Andhra Pradesh and Telangana have a 16.19 per cent prevalence of key NCDs which is higher than the national average of 11.62 per cent.These states particularly have a higher prevalence of non-communicable diseases (NCD) like hypertension, digestive diseases, diabetes, and neurological diseases as compared to the National Average Prevalence Rate of these diseases. This is similar to the overall national trend where hypertension, digestive disease, and diabetes emerge as the top three NCDs followed by respiratory diseases, brain disorders, heart diseases, kidney disorders, and cancer in the order of prevalence. The Associated Chambers of Commerce and Industry of India (ASSOCHAM), the apex trade association of the country, as part of its 'Illness to Wellness' campaign, on Friday unveiled Andhra Pradesh (now Andhra Pradesh and Telangana) specific findings of India's largest primary healthcare survey report on the rising burden of non-communicable diseases in the country. This was followed by a virtual panel discussion on "Non-Communicable Diseases: The New Health Challenges for Telangana and Andhra Pradesh". The survey report titled 'Non-Communicable Diseases in India' covered 2,33,672 people and 673 public health offices in 21 states to analyse the rising cases of NCDs in the country and the social profile of suffering households. Delving on the risk factors associated with NCDs, the report highlighted that significantly higher stress levels in the region than the national average are leading to heart, diabetes, and digestive disorders in Andhra Pradesh and Telangana. It stated that 63 per cent of respondents in the region face high stress. The report further underlined that the region has higher physical activities, which is reflected in lower BMI. However, the likely positive impact of the same on reducing the vulnerability to obesity related NCDs is significantly reduced by other factors like choice of food including salt and chillies intake and lifestyle choices. The study also found that high workplace pollution in the region is a major contributing factor to diseases related to neurology, heart, and lung. This is mainly due to high mining, stone quarrying, and construction activities in the region. Home air pollution was also found to be significantly contributing to hypertension and neurological disorders in the region. The problem of workplace air pollution was recognised by 82 per cent of the respondents while 76 per cent accepted that they face home air pollution. The region shows lower vegetable and fruit consumption coupled with high meat consumption than the national average. As per the study findings, 90 per cent of the respondents from Andhra Pradesh and Telangana consume non-vegetarian food with 68 per cent consuming red meat. This has implications on NCDs affecting the digestive system, heart, and hypertension. Incidentally, tobacco consumption was found to be below the national average in both the states, and thus their impact on the prevalence of NCDs relating to hypertension, heart diseases, and diabetes in the state is likely to be insignificant in line with the national findings. The study observed that while the national prevalence rate of hypertension is 3.60 per cent , its prevalence in the state of Andhra Pradesh and Telangana is 8.54 per cent . This is followed by digestive diseases and diabetes that have a prevalence rate of 5.65 per cent and 4.69 per cent respectively in both the states. Digestive diseases have a national average prevalence rate of 3.05 per cent while it is 2.85 per cent for diabetes. The prevalence rate of brain disorders and kidney diseases in each of these states stands at 2.52 per cent and 0.66 per cent respectively. This is again higher than the national average prevalence rate of 1.3 per cent for brain diseases and 0.4 per cent for kidney diseases. The prevalence of heart diseases, cancer, digestive diseases, and respiratory diseases were found to be lower in Andhra Pradesh and Telangana when compared to the national average prevalence rate for these diseases. The Covid-19 pandemic has brought a sharper focus on health care. Patterns emerging from Covid management across the country indicate that people with co-morbidities of non-communicable diseases (NCDs) have a higher mortality rate than those who do not. This has grave implications for the country not only because of mortality and years of healthy lives lost but also because of India's health infrastructure. Dr. C. H. Vasanth Kumar, Senior Consultant Physician, Apollo Hospitals, Hyderabad, Current President Elect, Research Society for Study of Diabetes in India (RSSDI), said, "NCDs are a real threat to human life as it affects everyone irrespective of age, the financial status or background. Prevention and early detection are key to arresting the rising cases of NCDs. Towards this, parents, society, and government must come together for a decisive win against the disease which is gripping the world including India." Dr K. S. Soma Sekhar Rao, Consultant Gastroenterologist & Hepatologist, Department of Medical Gastroenterology and Hepatology, Apollo Health City, Jubilee Hills, Hyderabad added, "Health education and forums like this can certainly go a long way in improving awareness about NCDs among the masses. An unhealthy gut is the mother of all diseases, and we must take good care of our gut from a very young age for a long and healthy life." Rajesh Kesari, Founder and Director, Total Care Control, said, "NCDs have become a major health challenge in each country of the world including India. The amount of people suffering from NCDs in our country is simply huge and a lot of lives have already been lost to these diseases. --IANS san/dpb
New Delhi, July 29 (IANS) While the pandemic has made people conscious about remaining active for health, fitness and immunity, there has been a significant rise in the number of people, particularly the middle-aged, experiencing 'stress fracture', doctors said on Thursday.The term stress fracture refers to a very small crack in the bone that can happen from repetitive trauma and is commonly found in the shin bone, foot, heel, hip, and lower back. Jumping up and down repeatedly, running long distances, or wearing wrong or worn-out footwear can cause a stress fracture. If left unattended, the pain at the site of stress fracture and around it may increase and increase the risk of suffering a complete fracture in the affected bone.Middle-aged people, who have not indulged in outdoor activities ever but started after lockdown was lifted, comprise 10 per cent of such patients in the past one year, said doctors at the Indian Spinal Injuries Centre (ISIC). "Most of the patients belong to the age group of 30-40 years, followed by 40-50 years. Upon investigation, most of these people were found to have never done rigorous exercises such as running, skipping, sports or jumping. However, with the discussion around health, immunity and fitness raging due to the pandemic, they chose to become active, which was a shock for their body that is both unaccustomed and unconditioned for such activities," said Maninder Shah Singh, Senior Consultant Orthopedics and Chief of Foot and Ankle Service, at ISIC. The injury begins with repetitive and excessive stress on the bone which can result in acceleration of normal bone remodeling, the production of micro fractures (caused by insufficient time for the bone to repair), the creation of a bone stress injury (that is, stress reaction), and, eventually, a stress fracture, Singh said.With the Covid-19 pandemic creating a havoc around the world, exercise was emphasised as a key pillar to maintain physical and mental health. Many people, thus, took up running, aerobics, and other exercises to keep themselves fit and healthy. But being unaccustomed to physical training and the sudden change in lifestyle, reduced exposure to sunlight which affected bone health due to low Vitamin D levels also increased the risk for stress fractures, said Dr Aashish Chaudhry, Managing Director and Head - Orthopedics and Joint Replacement dept, Aakash Healthcare, Dwarka."Stress fractures can result from increasing the intensity of an activity too quickly. When the bones are weak and subjected to unaccustomed force without enough time for recovery, it makes them susceptible to stress fractures," he added.Another reason is that people are working at home without proper guidance, the experts noted. "The primary reason for such a fracture is people are doing an activity which earlier they were not used to and they are not using proper equipment or care to do the activity. Beside this we are also seeing sports injuries and they have definitely doubled. And the reason is people want to do more activities, people are working out at home more without proper equipment and guidance, which leads to injuries in their joints and ligaments," said Dr Subhash Jangid, Director and Unit Head, Bone and Joint Institute, Fortis Memorial Research Institute, Gurugram.The doctors advise RICE treatment -- Rest, Ice, Compression and Elevation -- as first-aid. They also recommend complete rest for six weeks.--IANSrvt/in
New Delhi, July 27 (IANS) The havoc induced by Covid-19 has affected sleep, and increased stress and anxiety, impacting physical as well as mental health of people. Natural antioxidant Gamma Oryzanol may help improve sleep and anxiety, say health experts.Gamma Oryzanol is a mixture of antioxidant compounds in the bran's oil fraction. Isolation, loss of work, economic and health worries during the pandemic has dramatically altered the sleeping pattern of many.While the treatment of insomnia mostly involves pharmaceutical drugs, it comes with its own side effects and many people are not really open or they don't want to take pharmacotherapy because of the side effects. However, many studies are being done to find out certain natural substances, which can help in the treatment of insomnia and Gamma Oryzanol is one of them."There are several antioxidants available for enhancing our overall health. Recently discovered Gamma Oryzanol preliminarily extracted from rice bran, is an important antioxidant," said Dr Nand Kumar, Professor at the Psychiatry Department of AIIMS, New Delhi. "Gamma Oryzanol is a great natural antioxidant which has been derived from rice bran. Many studies have been done on this which have proved that Gamma Oryzanol is good for the treatment of insomnia," added Dr Pratibha Dogra, Head, Department of Respiratory and Sleep Medicine, W Pratiksha Hospital, Gurugram.Dogra said a 2017 study in Korea proved that it is a natural sleeping aid. The Covid-19 outbreak in early 2020 disrupted people's routines, lifestyle and sleep quality. Disruption in work, school and home has increased stress, anxiety, and depression."Managing stress level becomes really important as stress over a period of time can lead to many diseases like sleeplessness, depression, panic attack, high blood pressure, heart diseases and diabetes etc. Stress and related medical conditions can be naturally managed by lifestyle modifications, Dietary changes little medication and consumption of natural antioxidants," Kumar said.Gamma Oryzanol also helps alleviates high fat diet-induced anxiety behaviour through downregulation of dopamine and inflammation, he said, citing a recent scientific study. Further, the natural antioxisdant also significantly improves the symptoms of dementia, without compromising cognitive function or causing other major side effects, Kumar noted.--IANSrvt/bg