London- Adolescents who had received a mental health disorder diagnosis were often excluded from the labour market and education as young adults, finds a new study.
The study indicated that almost 11 percent of adolescents who had received a psychiatric diagnosis were excluded from the education and labour market for at least five years in their early adulthood.
"Vocational rehabilitation and tight collaboration between psychiatry and social services are important for enabling adolescents suffering from mental health problems to access the labour market," said lead author David Gyllenberg from the University of Turku (Finland).
For the study, published in the British Journal of Psychiatry, the team included 55,273 individuals after exclusions for intellectual disability, death or emigration.
The results are concerning because they highlight the link between mental health disorders and long-term exclusion from education and labour market.
In the study, long-term exclusion was defined as a period spent outside education or paid employment lasting a minimum of five years.
The link was particularly strong with those teenagers who had not completed their upper secondary education and who had been diagnosed with a mental health disorder.
Almost half of these teenagers who had experienced psychosis and almost three-quarters of teenagers who had been diagnosed with an autism spectrum disorder experienced long-term exclusion from education and labour market in their early adulthood.
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Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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Migraine is a debilitating neurological disease, ranking consistently among the top 10 leading causes of years lived with disability, worldwide. The main symptom of migraine is an enduring headache, along with symptoms such as severe pain on one side of the head or throbbing pain, sensitivity to light and sound, and nausea. Despite being a very common headache disorder that affects roughly 15 percent of the adult population worldwide, it remains inadequately understood and most neglected.
In Delhi, approximately 25 per cent of the population suffers from migraines, every year.
While migraine is an invisible condition, it can severely impact individuals across personal, professional and social domains, thus affecting the overall quality of life and productivity. Work-from-home, or the 'new normal,' has drastically impacted the lives of people suffering from migraines from an inability to concentrate at work to missed workdays. It has become even more urgent to ensure that individuals have the understanding and tools to effectively manage migraines.
There is a lack of understanding amongst people about the severity of migraines. In a study we recently conducted, about 50 to 60 per cent of migraineurs were undiagnosed, despite recurrent headaches. Because migraine falls on a spectrum, ranging from infrequent or mild attacks to recurrent ones, many pass it off as merely a headache'. With busy work-from-home schedules, paired with fear of contracting COVID-19 infection and difficulty in accessing in-person care, people are avoiding seeking medical help for the condition, instead attributing symptoms to associated comorbidities, such as stress or depression."
He continued, "Financial worries due to job loss or salary cuts also contribute to aggravated migraine attacks, which is more noticeable recently. The effects of migraine on one's quality of life also reportedly worsened, particularly for many migraineurs working as essential healthcare workers at this time.
Symptom neglect and failure to treat the condition can lead to migraines becoming chronic. A fundamental need is to recognize migraine as a serious condition with severe disability and adopt a holistic treatment approach. Early detection can be a key enabler of a smoother patient journey and an improved quality of life."
Here are 5 ways to manage your migraine while working from home:
Identify Risk Factors and Monitor Triggers
Migraines can begin at any age but tend to peak during one's prime productive years. Moreover, women are three times more likely to be affected than men, with prevalence peaking between the ages of 25 and 55 years.
Long hours of working from home, along with longer screen times, disrupted sleep schedules and irregular eating habits can increase stress levels. For migraineurs, such changes can become migraine triggers, exacerbating their condition. Identifying personal triggers can help individuals manage their migraines better.
Make The Right Choice for Diet and Lifestyle
Working from home can be hard, but a daily routine that optimizes your physical and mental health can help keep your migraine at bay. Eating healthy meals at appropriate times or consuming small, frequent meals throughout the day are associated with less frequent migraine headaches. Taking breaks from work at regular intervals can help you eat right and reduce eye strain owing to excessive screen use. Making modifications to your lifestyle, including smoking cessation and reduced alcohol consumption, and maintaining optimal sleeping habits and exercising regularly can be key to manage migraines. These also benefit migraine prevention and treatment.
Talk to An Expert
It is important to consult a medical specialist when you are experiencing severe headaches that disrupt your daily routine. A lot of migraineurs hesitate to seek medical help. This could be due to several reasons lack of understanding of migraine severity, lack of time due to hectic work-from-home schedules, or recently, due to a reduction in-person clinic consultations owing to the fear of Covid-19 infection. However, consulting a neurologist, even via teleconsultations, is a necessary step to diagnose your condition and understand the available options for acute and chronic management of migraine, including preventive treatment. With evidence-based information on effects across migraine intensity reduction, quality of life and ease of use, neurologists can guide you on the most suitable treatment option to prevent or reduce your migraine episodes.
Track Your Migraines
It is a good idea to maintain a diary (or download a migraine tracker app), to record the time and severity of your migraine attacks, symptoms, daily diet, exercise routines, and medications and side effects. This can help identify triggers and patterns. It can also prompt meaningful conversations with your doctor, contributing to a more holistic treatment plan, personalized to suit your work schedule.
Seek Support From Your Family, Friends or Colleagues
Living with migraines can make one feel helpless, distressed and misunderstood. But talking to your friends and family will help them understand your condition better. Having an open conversation about your migraine with your employer is a good idea, particularly to work out a schedule, with specific routine adjustments to mitigate triggers. This can help you be productive and healthy while working from home. Employers can also take the initiative -- arranging wellness programs for employees to raise awareness about migraines and how to effectively manage them at work and enhance productivity.
Migraine attacks can be challenging. Changes to your daily routine and active communication about your condition with your employer, after consulting a neurologist, can help you better manage migraines as you work from home.
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Hong Kong, Aug 17 (IANS) The risk of rare Bell's palsy after taking Pfizer's Covid vaccination is very less, finds a study published in The Lancet Infectious Diseases journal, suggesting that the protective effects of the vaccines far outweigh the risk.Bell's palsy is the sudden onset of one-sided facial paralysis. In the majority of cases (70 per cent), the condition resolves itself within six months without treatment and the chance of recovery is even higher (90 per cent) if patients receive early treatment with corticosteroids.Researchers at the University of Hong Kong analysed cases of Bell's palsy related to the two approved vaccines in Hong Kong -- China's CoronaVac and US-based Pfizer.The team found that for every 100,000 people vaccinated with China's inactivated vaccine CoronaVac, an additional 4.8 people may develop the condition, but for the Pfizer-BioNTech vaccine, the increased risk was equivalent to an additional 2 cases per 100,000 people vaccinated.For the study, the team included 298 Bell's palsy cases and 1,181 matched controls from 2010-2020.The team estimated the background risk of Bell's palsy in Hong Kong -- around 27 cases per 100,000 people, per year. Global estimates range from 15-30 cases per 100,000 people, per year.The study found that receiving CoronaVac was associated with 2.4 times increased risk of Bell's palsy (95 per cent) whereas receiving Pfizer vaccine was not associated with a significantly increased risk."Our study suggests a small increased risk of Bell's palsy associated with CoronaVac vaccination. Nevertheless, Bell's palsy remains a rare, mostly temporary, adverse event. All evidence to date, from multiple studies, shows that the beneficial and protective effects of the inactivated Covid-19 vaccine far outweigh any risks," said lead author Professor Ian Chi Kei Wong, from the varsity."Ongoing surveillance, through pharmacovigilance studies such as ours are important to calculate with increasing levels of confidence the risks of rare adverse events," Wong added.However, the team noted that the study is limited to patients with a new diagnosis of Bell's palsy in Hong Kong, so further studies in other regions should be done to confirm the findings.The US Federal Drug Administration (FDA) does not consider a clear causal association between the condition and vaccines by Pfizer-BioNTech and the Moderna, but recommends ongoing surveillance. Acute partial facial paralysis is reported as a rare side effect of both vaccines by the European Medicines Agency.--IANSrvt/vd
London, Aug 15 (IANS) Researchers at University College London conducted a study of people with cerebral venous thrombosis (CVT) following Covid-19 vaccination, to provide a clearer guide for clinicians trying to diagnose and treat such patients.The research, published in The Lancet, is the most detailed account of the characteristics of CVT, when it is caused by the novel condition vaccine-induced immune thrombotic thrombocytopenia (VITT).VITT is a condition characterised by a blockage of the veins and a marked reduction of platelets, blood components which are an important part of the blood clotting system. The commonest and severest manifestation of VITT is CVT, in which veins draining blood from the brain become blocked.The study looks in detail at 70 patients with VITT-associated CVT following vaccination, who were then compared to 25 patients with CVT but without the evidence of VITT.The study provides support for the three principles of treatment established so far by the Expert Hematology Panel, based on early work at UCL and two other European sites.The use of non-heparin-based anticoagulation; give treatments to try to reduce the level of the abnormal antibody that is implicated in this condition; and avoid the strategy of trying to bring the platelet count back up to normal levels by giving platelet transfusions."We found that those patients who were given intravenous immunoglobulin -- the treatment in which the body is flooded with normal antibodies to try to reduce the effects of the abnormal one -- were more likely to leave hospital alive and able to live an independent life rather than depending on carers or family to look after them," Dr Alastair Webb, consultant neurologist at the John Radcliffe Hospital in Oxford said.On the other hand, platelet transfusions were associated with a worse outcome in patients with VITT-associated CVT. Although observational data cannot prove harm from this treatment approach, the study provides support for the concern that has already been raised about the potential harm of platelet transfusions.However, the researchers also suggest that some treatments such as intravenous immunoglobulin seem to be associated with better outcomes but caution against reading too much into the findings of the observational study, saying that reliable evidence about treatments can only be obtained in a randomised clinical trial.--IANSrvt/skp/
New Delhi, Aug 13 (IANS) A group of 23 MPs from the Rajya Sabha met Union Health and Family Welfare Minister Mansukh Mandaviya seeking the ministry's immediate intervention to provide treatment to eligible patients diagnosed with Group 3 (a) rare genetic conditions, like Lysosomal Storage Disorders (LSDs).The Parliamentary group also submitted a memorandum to Mandaviya, drawing his attention to the urgent need for prioritisation of treatment for patients diagnosed with Group 3(a) rare genetic conditions. "Despite the notification of the much-awaited National Policy for Rare Diseases, 2021 in March this year, these patients continue to be at grave risk due to the lack of any sustainable funding mechanism for treatment," the MPs said."We would like to draw your immediate attention towards the need to prioritise treatment for at least the ultra-rare diseases -- treatable conditions which have an even lesser prevalence as compared to others; and for which the Drugs Controller General of India (DCGI) approved therapies are available in India," the memorandum stated, requesting the Union Minister to: (a) Extend the Umbrella Scheme of Rashtriya Arogya Nidhi (RAN) to all Group 3 (a) patients with treatable conditions, and (b) Transfer the unspent funds from the previous years' budgetary allocation to provide treatment for eligible patients diagnosed with treatable conditions."Several countries, including the developing economies like Brazil, Argentina, Algeria, and Egypt, have robust reimbursement mechanisms in place (often 100 per cent) for dealing with rare diseases, or have earmarked funds out of their healthcare budgets, specifically for these purposes," the members wrote, explaining that unlike diabetes or any other common ailment, the number of rare disease patients is very small. "Without any support from the government, parents of these children are left with no option but to look on in despair, despite the availability of approved therapies in India," the statement said.Led by Fauzia Khan and her party colleague from the Nationalist Congress Party (NCP). Vandana Chavan, the memorandum was signed by MPs from several states, including Maharashtra, Kerala, West Bengal, Tamil Nadu, Odisha, Rajasthan and Gujarat, to name a few."While we welcome the Government of India's efforts to mobilise funds through crowdfunding and involving corporate India and the PSUs, this process may take some time. Through this joint representation, we would like to draw your immediate attention to the condition of close to 200-odd eligible patients -- diagnosed with Group 3(a) disorders -- whose lives are at risk owing to the long delay in providing support for treatment," they stated.--IANSmiz/dpb