Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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Snoring can be frustrating and annoying, especially for those who sleep with a snorer. The National Sleep Foundation reports that one in three men and four women snore every night.
Though snoring is often overlooked as a minor issue, it can occur due to various reasons requiring immediate attention. Obesity or being overweight is one of the leading causes of snoring. Snoring accompanied by irregular breathing is a sign of cardiovascular disease risk. Sleep apnoea can be another condition that increases the chances of snoring. Sleep apnoea is a sleep disorder in which the breathing repeatedly stops and resumes again. Fortunately, plenty of remedies are available to treat snoring naturally without using over-the-counter (OTC) drugs.
Obesity or Excess Weight
For those who have started snoring after gaining weight, shedding some extra pounds can be quite helpful. Obese people tend to have excess tissue and fat in the neck region, which can reduce the airway size and elevate the risk of airway collapse. Studies have proved that weight reduction can eliminate the frequency of snoring with increased weight losses causing near to complete elimination of snoring.
Snoring accelerates when people lie in the supine position or on their backs. When someone lies down on the back, the tissues surrounding the airway are pulled down by gravity, making it narrow. Research and studies on snorers have revealed that the intensity and frequency of snoring reduce considerably when they lie on their sides.
Blocked Nasal Passages
Snoring can also be prevented by keeping the nasal passages open. When the nose is clogged or blocked, air moves in much faster, leading to snoring. Hot oil massages or nasal oil drops can open the blockages in the nose. Also, a hot shower before bed can be quite beneficial as the moisture opens the nasal passages and reduces the chances of snoring.
Staying hydrated is crucial not only to avoid snoring but also to maintain overall health and well-being. When the body is dehydrated, secretions in the nose and soft palate becomes stickier. This can obstruct the proper flow of air and cause snoring. For men, it is recommended to consume at least 3-4 litres of fluid every day, while women must consume 2-3 litres of fluids daily.
Smoking and Alcohol
Researchers believe that snoring in smokers can occur because of oedema and upper airway inflammation. While it takes time to show the effects but quitting smoking can significantly lessen the chances of snoring. Alcohol is another substance that relaxes the muscles around the airway, increasing the likelihood to snore among drinkers. Therefore, it is often recommended not to indulge in drinking in the hours leading to bedtime.
The tips mentioned above can bring positive results if tried daily. It is important to try them all to find the ideal remedy that helps.
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मेदोहर गुग्गुलु - मेद रोगों ( मोटापा) में लाभकारी : मेदोहर गुग्गुलु आयुर्वेद वर्णित भेद (अतिरिक्त वसा) कम करने वाली सर्वश्रेष्ठ औषधि है..त्रिफला, त्रिकटु, वावडिंग, चित्रक मूल व गुग्गुलु के सहयोग से तैयार किया गया एक प्रसिद्ध योग है. मेदोहर गुग्गुलु मेद रोगों के लिए आयुर्वेद में वर्णित सर्व प्रसिद्ध औषधि है. यह शरीर में फैट (वसा) मेटाबोलिज्म को ठीक कर अतिरिक्त फैट (वसा) की मात्रा को कम करता है.
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Canberra, June 9 (IANS) Australia's peak medical body has called on the government to implement a tax on sugary beverages to combat obesity, diabetes and poor health.In an address at the National Press Club Wednesday, President of the Australian Medical Association (AMA) Omar Khorshid advocated for a tax that would reduce the consumption of sugary drinks, Xinhua reported."More than 2.4 billion liters of sugary drinks are consumed every year in Australia. That's enough to fill 960 Olympic-sized swimming pools," he said."Diabetes, obesity and poor vascular health are huge contributors to the burden on our health system.""Sugary drinks, and in particular those which have little or no nutritional value, fuel this problem. It is time for action."A study published by the Australian Institute of Health and Welfare in 2019 found that 9.1 per cent of Australian adults consumed sugar-sweetened drinks daily.According to the Australian Bureau of Statistics, an average Australian consumes 60 grams, or 14 teaspoons, of sugar every day.AMA has proposed that the retail price of sugar-sweetened beverages should increase by 20 per cent on average.According to Khorshid, this is in line with a recommendation by the World Health Organisation, and could, over a 25-year period, result in 16,000 fewer cases of type 2 diabetes, 4,400 fewer cases of heart disease and 1,100 fewer cases of stroke."It could save lives, and save millions of dollars in healthcare costs," he said. "It would also generate revenue - we estimate about 814 million Australian dollars (about 630 million US dollars) annually - which we believe could be spent on other preventative health activities."--IANSint/
New York, June 4 (IANS) Covid-19 survivors who have moderate or severe obesity may have a greater risk of experiencing long-term consequences of the disease, compared to the patients who do not have obesity, showed an observational study.Obesity is known to weaken the immune system and create a chronic inflammatory state. These conditions can lead to poor outcomes after an infection with SARS-CoV-2, which is the virus that causes Covid-19, as per the study."To our knowledge, this current study for the first time suggests that patients with moderate to severe obesity are at a greater risk of developing long-term complications of Covid-19 beyond the acute phase," said Ali Aminian, director of Cleveland Clinic's Bariatric & Metabolic Institute.The study, published online in the journal 'Diabetes, Obesity and Metabolism', showed that compared to patients with normal body mass index (BMI), the risk of hospital admission was 28 per cent and 30 per cent higher in patients with moderate and severe obesity, respectively.AIn patients with a BMI of 35 or greater, the need for diagnostic tests to assess cardiac, pulmonary, vascular, renal, gastrointestinal, and mental health problems was significantly higher. compared with normal BMI patients."The observations of this study can possibly be explained by the underlying mechanisms at work in patients who have obesity, such as hyper-inflammation, immune dysfunction, and comorbidities," said Bartolome Burguera, chair of Cleveland Clinic's Endocrinology & Metabolism Institute."Those conditions can lead to poor outcomes in the acute phase of Covid-19 in patients with obesity and could possibly lead to an increased risk of long-term complications of Covid-19 in this patient population," Burguera added.The team included a total of 2,839 patients who did not require ICU admission and survived the acute phase of Covid-19. The normal BMI group was considered as a reference. Obesity is a disease classified as having a BMI of 30 or greater.--IANSrvt/arm
New Delhi, May 28 (IANS) Strong regulations to cap salt, sugar and other harmful ingredients and simple to understand front of package labelling (FOPL) on junk food packets can help curb the alarming rise in childhood obesity in India, say public health experts and doctors, in a webinar organised by All India Institute of Medical Sciences (AIIMS) Rishikesh on Friday.Warning labels are critical to help consumers and parents understand how much empty calories and harmful nutrients are being consumed by children."Food labels should provide clear guidance... Simple to understand labels with evidence based nutrition cut-off is a need of the hour and will go a long way to address the crisis of childhood obesity in the country," said Umesh Kapil, Professor, Clinical Epidemiology, Indian Institute of Biliary Sciences.The experts also urged that India must rapidly adopt the World Health Organization (WHO) recommended limits and also introduce simple, smart and interpretative FOPL."There is enough scientific evidence and a globally agreed WHO SEARO framework for evidence-based cut-offs for anti-nutrients like sugar, salt and saturated fat present in packaged food," Kapil added.WHO has identified FOPL as "one of the policy tools that can support healthy diets, both in stimulating consumers to make informed healthier food choices and in driving manufacturers to reformulate products to avoid making unfavourable nutrient content disclosure."With more than 14.4 million obese children, India has the second highest number of children with childhood obesity in the world. By 2025 this number is expected to reach a staggering 17 million. As is the trajectory in other developing nations, the proportion of packaged and ultra-processed foods is on the rise.There is growing evidence that the Covid-19 pandemic could potentially increase the risk of children becoming obese. School closures and lockdowns have already deprived millions of children of nutritional school meals, sports and adequate physical exercise."Being overweight or obese is directly associated with life-threatening noncommunicable diseases such as cardiovascular disease, diabetes and cancer. Obesity is a result of imbalance between calories consumed and calories expended," said Rekha Harish, Chairperson, Indian Academy of Paediatrics, NCD Prevention.The only way to control this growing epidemic of obesity is by establishing scientific cut-off limits for harmful ingredients and FOPL on packaged products, the experts suggested."Children are particularly at risk. As doctors, we want to assert that the onus should not be on children or their families alone to prevent or fight this condition. It is the collective duty of policymakers, the food industry and us as doctors to safeguard children and enable a nutritious food system for them," said Manoj Kumar Gupta, Dean, AIIMS Rishikesh.--IANSrvt/sdr/
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