Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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Snoring can be frustrating and annoying, especially for those who sleep with a snorer. The National Sleep Foundation reports that one in three men and four women snore every night.
Though snoring is often overlooked as a minor issue, it can occur due to various reasons requiring immediate attention. Obesity or being overweight is one of the leading causes of snoring. Snoring accompanied by irregular breathing is a sign of cardiovascular disease risk. Sleep apnoea can be another condition that increases the chances of snoring. Sleep apnoea is a sleep disorder in which the breathing repeatedly stops and resumes again. Fortunately, plenty of remedies are available to treat snoring naturally without using over-the-counter (OTC) drugs.
Obesity or Excess Weight
For those who have started snoring after gaining weight, shedding some extra pounds can be quite helpful. Obese people tend to have excess tissue and fat in the neck region, which can reduce the airway size and elevate the risk of airway collapse. Studies have proved that weight reduction can eliminate the frequency of snoring with increased weight losses causing near to complete elimination of snoring.
Snoring accelerates when people lie in the supine position or on their backs. When someone lies down on the back, the tissues surrounding the airway are pulled down by gravity, making it narrow. Research and studies on snorers have revealed that the intensity and frequency of snoring reduce considerably when they lie on their sides.
Blocked Nasal Passages
Snoring can also be prevented by keeping the nasal passages open. When the nose is clogged or blocked, air moves in much faster, leading to snoring. Hot oil massages or nasal oil drops can open the blockages in the nose. Also, a hot shower before bed can be quite beneficial as the moisture opens the nasal passages and reduces the chances of snoring.
Staying hydrated is crucial not only to avoid snoring but also to maintain overall health and well-being. When the body is dehydrated, secretions in the nose and soft palate becomes stickier. This can obstruct the proper flow of air and cause snoring. For men, it is recommended to consume at least 3-4 litres of fluid every day, while women must consume 2-3 litres of fluids daily.
Smoking and Alcohol
Researchers believe that snoring in smokers can occur because of oedema and upper airway inflammation. While it takes time to show the effects but quitting smoking can significantly lessen the chances of snoring. Alcohol is another substance that relaxes the muscles around the airway, increasing the likelihood to snore among drinkers. Therefore, it is often recommended not to indulge in drinking in the hours leading to bedtime.
The tips mentioned above can bring positive results if tried daily. It is important to try them all to find the ideal remedy that helps.
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Lifestyle plays a huge role in your fitness and health. Often a sedentary lifestyle along with unhealthy eating habits contribute to weight gain or other lifestyle diseases. With discipline and patience, you can work on your lifestyle to reach a fitness level you have always desired. Always remember that whatever changes you implement should not be focused on temporary results, but rather on a long and sustainable lifestyle.
A good fitness level is more important than just fat loss. However, you can lose fat by practising these things:
1. Make Your Diet A Lifestyle:
Most people tend to focus on diet as a destination, rather than a journey. Your nutrition should not be a trend or a plan for short-term results, but rather a lifestyle that you can follow effortlessly. Although easier said than done, implementing a positive lifestyle can have tremendous long-term results. Tweaking your food habits and incorporating essential macro and micronutrients can aid your fat-loss journey. A good way to include the right food components in your diet is through a good diet plan which you must follow with discipline. Eat good food every day. It's as simple as that. Don't divert even if you have to eat the same food every day, you can always innovate your dishes with the help of spices and other preparation methods.
2. Workout Regime To Increase Activity:
Even if you can't do a heavy workout every day, it is essential to include some kind of activity in your lifestyle. Find a physical activity that suits you. Some people despise gyms, but love jogging or playing a sport. Some like strength training and lifting weights. Whatever you choose, follow through without any excuses. Your daily physical activity plays a huge role in your metabolism and fitness level. It's not just about burning calories; it's about setting a pattern for your body to undergo positive stress. When you exercise, your body is already doing half the work required for losing weight and becoming fit.
3. Don't Compromise on Your Sleep and Hydration:
People underrate the importance of a good night's sleep. Your body requires sleep to recover, to balance the cortisol hormone level which is responsible for your binge eating. Sleeping is our body's natural way of balancing the stress level and rectifying any errors in its system. Fix a sleeping time and don't change it no matter what. This is one of the most important changes you must incorporate. The other being hydration water is extremely important for your system. Not only does it help in passing the nutrients throughout your system, but it also helps the body detox and shed the pesky water retention habit. You'll be surprised by the number of times your body confuses thirst for hunger, so always drink adequate water. Set a reminder through a phone app, it can be helpful.
(The author Pranit Shilimkar is a Health and Fitness Entrepreneur, Digital Content Creator and Founder of Fitnesstalks)
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New Delhi, Aug 20 (IANS) The American-based pharma major Johnson & Johnson (J&J) has applied to the Central Drugs Standard Control Organisation (CDSCO) for permission to conduct a vaccine trial of the Covid-19 single shot Janssen vaccine in India on children of 12-17 age group.The American pharma J&J said in a statement that it had submitted its application on Tuesday, and that it is "imperative" to ensure all sections of the population, including children, are vaccinated against the coronavirus as quickly as possible to stop the virus.The single-shot vaccine of J&J is the second Covid-19 vaccine which has already been approved for the Emergency Use Authorisation (EUA) through the fast-track approval route by the Drug Controller General of India.In the statement, Johnson & Johnson India also said this was an important step forward in accelerating the availability of its Covid-19 vaccine to help end the pandemic.Earlier, the Union Health Minister Mansukh Mandaviya had tweeted about the Emergency Use Authorisation being given to Johnson & Johnson.Mandaviya had tweeted, "India expands its vaccine basket! Johnson and Johnson's single-dose COVID-19 vaccine is given approval for Emergency Use in India. Now India has 5 EUA vaccines. This will further boost our nation's collective fight against COVID19."The five vaccines which have been granted emergency use authorization approval in India include Serum Institute's Covishield, Bharat Biotech's Covaxin, Russia's Sputnik V, Moderna and now Johnson & Johnson (J&J).--IANSavr/dpb
Tel Aviv, Aug 20 (IANS) Israel has decided to lower the eligibility age for the third dose of A Covid-19 vaccine from 50 to 40, a local media report said.The expert committee of the Health Ministry recommended vaccinating people aged over 40, as well as teachers of all ages due to the recent sharp rise in Covid-19 infections in the country, Xinhua news agency quoted the report by Israel's state-owned Kan TV news as saying.The decision is expected to take effect by Friday after an approval by the Ministry's Director General, Nachman Ash.So far, nearly 1.25 million people have received the third dose in Israel, out of about 1.9 million aged 50 and over who took the second shot more than five months earlier.The number of people who have received the first doses of the Covid-19 vaccine in Israel reached nearly 5.88 million, or 63 per cent of its total population, while over 5.4 million have taken two doses and nearly 1.25 million have got three jabs.--IANSksk/
Berlin, Aug 18 (IANS) Daily Covid-19 infections in Germany recorded a sharp increase as 8,324 new cases were registered within one day, 3,328 more than one week ago, the Robert Koch Institute (RKI) said on Wednesday.The last time that new infections within 24 hours exceeded 8,000 was during the third wave in mid-May. After the situation had calmed down for a while, new infections in Germany have been rising since the beginning of July, the Xinhua news agency reported.The country's vaccination campaign slowed down considerably recently and Germany's virologist Christian Drosten issued a clear warning to unvaccinated people. "Those who do not get vaccinated will get infected, and perhaps as early as this winter," he told German press agency dpa on Wednesday, Xinhua reported.Due to the particularly contagious nature of the Delta variant and the fact that vaccinated people could pass on the coronavirus too, unvaccinated people could no longer hope for protection through herd immunity."Everyone, in particular those 45 and older, is strongly advised to take a very serious look at whether they really do not want to be vaccinated," Drosten said.More than 48.1 million people in Germany were fully vaccinated as of Wednesday, bringing the country's vaccination rate to 57.8 percent, according to the RKI, the federal government agency for disease control and prevention. More than 52.8 million Germans received at least one dose.The incidence rate of reported Covid-19 cases in Germany in the past seven days per 100,000 citizens also continued to rise and reached 40.8 on Wednesday, up from 37.4 the previous day and 25.1 a week ago, according to the RKI.To date, more than 3.8 million COVID-19 infections have been officially registered in Germany since the outbreak of the pandemic. The death toll climbed to 91,921 on Wednesday, said the RKI.--IANSint/arm