Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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Snoring can be frustrating and annoying, especially for those who sleep with a snorer. The National Sleep Foundation reports that one in three men and four women snore every night.
Though snoring is often overlooked as a minor issue, it can occur due to various reasons requiring immediate attention. Obesity or being overweight is one of the leading causes of snoring. Snoring accompanied by irregular breathing is a sign of cardiovascular disease risk. Sleep apnoea can be another condition that increases the chances of snoring. Sleep apnoea is a sleep disorder in which the breathing repeatedly stops and resumes again. Fortunately, plenty of remedies are available to treat snoring naturally without using over-the-counter (OTC) drugs.
Obesity or Excess Weight
For those who have started snoring after gaining weight, shedding some extra pounds can be quite helpful. Obese people tend to have excess tissue and fat in the neck region, which can reduce the airway size and elevate the risk of airway collapse. Studies have proved that weight reduction can eliminate the frequency of snoring with increased weight losses causing near to complete elimination of snoring.
Snoring accelerates when people lie in the supine position or on their backs. When someone lies down on the back, the tissues surrounding the airway are pulled down by gravity, making it narrow. Research and studies on snorers have revealed that the intensity and frequency of snoring reduce considerably when they lie on their sides.
Blocked Nasal Passages
Snoring can also be prevented by keeping the nasal passages open. When the nose is clogged or blocked, air moves in much faster, leading to snoring. Hot oil massages or nasal oil drops can open the blockages in the nose. Also, a hot shower before bed can be quite beneficial as the moisture opens the nasal passages and reduces the chances of snoring.
Staying hydrated is crucial not only to avoid snoring but also to maintain overall health and well-being. When the body is dehydrated, secretions in the nose and soft palate becomes stickier. This can obstruct the proper flow of air and cause snoring. For men, it is recommended to consume at least 3-4 litres of fluid every day, while women must consume 2-3 litres of fluids daily.
Smoking and Alcohol
Researchers believe that snoring in smokers can occur because of oedema and upper airway inflammation. While it takes time to show the effects but quitting smoking can significantly lessen the chances of snoring. Alcohol is another substance that relaxes the muscles around the airway, increasing the likelihood to snore among drinkers. Therefore, it is often recommended not to indulge in drinking in the hours leading to bedtime.
The tips mentioned above can bring positive results if tried daily. It is important to try them all to find the ideal remedy that helps.
Read More► Here's How to Optimise Stress, Sleep and Immunity
Rome, Aug 12 (IANS) The coronavirus pandemic will continue to influence the mobility of workers and students for months to come in Italy, a report showed on Wednesday."A greater use of remote working and learning suggests a change in the travelling habits of employees and students," Italy's National Institute of Statistics (ISTAT) wrote in the report."While over 80 per cent commuted at least five times a week before the pandemic, less than 70 per cent are planning to do so with the same frequency next fall."Among the employees and students involved in the study, more than 50 per cent of those planning to change their mobility behaviour cited the coronavirus emergency as the main reason, the Xinhua news agency reported.ISTAT also predicted a change in transport habits, with the number of people commuting on public transport forecast to drop to 22.6 per cent after the summer break, compared to 27.3 per cent before the pandemic.These data came despite the progress of Italy's domestic vaccination campaign, which has seen 64.66 per cent of the target population (or 34.9 million people) fully immunised as of Wednesday.The pandemic will also reduce the frequency of travel for work and study, according to the statistics agency.The study was carried out as part of ISTAT's July consumer confidence survey on a sample of some 2,000 citizens aged 18 or over. --IANSint/rs
Toronto, Aug 10 (IANS) Depression and anxiety symptoms have doubled in children and adolescents when compared to pre-pandemic times, according to an alarming study.Researchers at the University of Calgary conducted a meta-analysis, pooling together data from 29 separate studies from around the world, including 80,879 youth globally.The findings, published in the medical journal JAMA Pediatrics, showed that an alarming percentage of children and adolescents are experiencing a global-wide mental crisis due to the Covid-19 pandemic."Estimates show that one in four youth globally are experiencing clinically elevated depression symptoms while one in five have clinically elevated anxiety symptoms," said lead author Dr Nicole Racine, a postdoctoral associate, and clinical psychologist at the varsity. More alarmingly, these symptoms are compounding over time.The study -- which incorporates 16 studies from East Asia, four from Europe, six from North America, two from Central and South America and one from the Middle East -- also shows that older adolescents and girls are experiencing the highest levels of depression and anxiety."We know from other studies that rates of depression and anxiety in youth tend to ebb and flow with restrictions. When more restrictions are imposed, rates go up. Being socially isolated, kept away from their friends, their school routines, and social interactions has proven to be really hard on kids," said Dr Sheri Madigan, a Calgary varsity clinical psychologist.Older teens in particular have missed out on significant life events such as graduations, sporting events, and various coming of age activities."These kids didn't imagine that when they graduated, they'd never get to say goodbye to their school, their teachers or their friends, and now they're moving on to something new, with zero closure," Racine said. "There's a grieving process associated with that."While mental health symptoms in youth are rising, more mental health support should be put in place to help children and adolescents in this time of need."If we want to mitigate the sustained mental health effects of Covid-19, because of the chronic stressors our youth experienced, we have to prioritise recovery planning now. Not when the pandemic is over, but immediately. Because kids are in crisis right now," Madigan said.--IANSrvt/vd
Jaipur, Aug 4 (IANS) Addressing a webinar on ‘Fighting nutrition crisis in India during Covid-19, especially for women and children in India', several experts on Wednesday raised concern over the adverse effects of the pandemic which are affecting millions of children and women due to lack of intake of quality food and micronutrients.Speaking on the occasion, Sudhir Bhandari, Principal, SMS Medical College, Jaipur, said, "India initially faced physical challenges during Covid-19. However, over time, we realised how nutrition affected the lives of many. Around 9.3 million children would be affected by 2022 out of which 20-25 per cent might suffer due to stunted growth. "Children experiencing under-nutrition are more likely to suffer from pandemic complications as it may cause more sickness and mortality due to Covid-19 and other infectious and inflammatory diseases, including pneumonia.""In countries with the 1st and 2nd waves of Covid-19, obesity and non-communicable diseases have been associated with the more severe outcome of the virus. Covid-19 has had a severe effect on maternal and young children's nutritional status. We must strengthen the food security and functioning of the food supply chain to the population."Bhandari added that last year, almost 58 million children between the age group of 6 months and 23 months did not develop the right eating habits.D.K. Mangal, advisor, SD Gupta School of Public Health at IIHMR University, said, "India bears a disproportionate burden of malnutrition. Response to the pandemic has disrupted routine nutrition programmes such as the ICDS and the Mid-Day Meal programme. This has adversely affected the nutrition status of millions of children and women." The webinar was organised by the NGO Saksham Sanchar. --IANSarc/arm
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►थाइरोइड ग्रंथि को उत्तेजित करता है जिससे शरीर की उपापचय दर (बी.एम.आर.) बढ़ जाती है
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यह भी पढ़े ► योगराज गुग्गुलु के फायदे