As we go through studies claiming that widely-available mouthwashes can kill the deadly novel coronavirus, health experts in India cast doubts on such studies, stressing that people should not treat mouthwash as a prevention method from Covid-19 unless proven in clinical settings.
According to them, any study should not be referred to till it confirms the final outcome and the results cannot be assured till researchers themselves share the final report.
Recently, a study from Cardiff University in the UK, which has not yet been peer-reviewed or published in a medical journal, found that some mouthwashes could help to kill the coronavirus in saliva.
Speaking to IANS, Dr. Manoj Goel, Director, Pulmonology, Fortis Hospital in Gurugram, said that the study claim needs to be peer-reviewed before its publication to establish its merit.
"Covid-19 can infect a person through the nose and eyes also besides the mouth. The infection through the mucous membrane occurs much faster. Hence theoretically mouth wash for prevention from Covid-19 appears to be doubtful," Goel said.
"But having said maintaining good oral hygiene is an important component of healthy living and should be practiced regularly irrespective of Covid infection," he added.
According to Animesh Arya, Senior Consultant in Respiratory Medicine, Sri Balaji Action Medical Institute in New Delhi, there are a number of trials and stages that take place in the process of research.
The results cannot be assured till researchers themselves share the final report.
"It is wise to use mouthwash as it helps to reduce the virus and bacteria in the mouth, but final evidence in regard to killing coronavirus is still awaited," Arya said.
Another study published in the Journal of Medical Virology in October also claimed that certain oral antiseptics and mouthwashes might have the ability to inactivate human coronaviruses.
Dr. Shiba Kalyan Biswal, Consultant, Pulmonary and Sleep Medicine, Narayana Hospital in Gurugram told IANS: "Using mouthwash is a good option for oral health which helps in decreasing the chances of virus and bacteria in the mouth, but till the study itself confirms with final result it is not wise to consider it as the solution to kill the coronavirus." (IANS)
London - Researchers have once again claimed that widely-available mouthwashes have killed Coronavirus, responsible for the Covid-19 disease, within 30 seconds of exposure in laboratory conditions.
The study this time from Cardiff University in the UK, which has not yet been peer-reviewed or published in a medical journal, found that some mouthwashes could help to kill the Coronavirus in saliva.
According to the BBC, while the research suggests use of mouthwash may help kill the virus in saliva, there is not evidence it could be used as a treatment for coronavirus, as it will not reach the the respiratory tract or the lungs.
"The ability of mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting reduction in infectivity," said the study authors,
The mouthwashes were tested in the laboratory under conditions that are designed to mimic the oral/nasal cavity in a test tube.
The researchers revealed that mouthwashes containing at least 0.07 per cent cetypyridinium chloride showed "promising signs" of virus-killing potential.
"This study adds to the emerging literature that several commonly-available mouthwashes designed to fight gum disease can also inactivate the SARS-CoV-2 coronavirus (and other related coronaviruses)," study lead author Richard Stanton was quoted as saying to the BBC.
According to the research team, clinical trial will look at whether it helps to reduce levels of the virus in the saliva of Covid-19 patients at the hospital in Cardiff, with results expected early next year.
Researcher David Thomas said the initial results were encouraging, but the clinical trial would not produce evidence of how to prevent transmission between patients.
"Whilst these mouthwashes very effectively eradicate the virus in the laboratory, we need to see if they work in patients and this is the point of our ongoing clinical study," he said.
Another study published in the Journal of Medical Virology in October also revealed that certain oral antiseptics and mouthwashes might have the ability to inactivate human coronaviruses. (IANS)
New York - In a fight against the novel coronavirus, scientists have found that certain oral antiseptics and mouthwashes may have the ability to inactivate human coronaviruses.
The results, published in the Journal of Medical Virology, indicate that some of these products might be useful for reducing the amount of virus in the mouth after infection and may help to reduce the spread of SARS-CoV-2, the coronavirus that causes Covid-19.
"While we wait for a vaccine to be developed, methods to reduce transmission are needed. The products we tested are readily available and often already a part of people's daily routines," said study researcher Craig Meyers from the Penn State University in the US.
During the study, the research team tested several oral and nasopharyngeal rinses in a laboratory setting for their ability to inactivate human coronaviruses, which are similar in structure to SARS-CoV-2.
The products evaluated include a one per cent solution of baby shampoo, peroxide sore-mouth cleansers, and mouthwashes.
The researchers found that several of the nasal and oral rinses had a strong ability to neutralize human coronavirus, which suggests that these products may have the potential to reduce the amount of virus spread by people who are Covid-19-positive.
They used a test to replicate the interaction of the virus in the nasal and oral cavities with the rinses and mouthwashes.
They treated solutions containing a strain of human coronavirus, which served as a readily available and genetically similar alternative for SARS-CoV-2, with the baby shampoo solutions, various peroxide antiseptic rinses and various brands of mouthwash.
They allowed the solutions to interact with the virus for 30 seconds, one minute and two minutes, before diluting the solutions to prevent further virus inactivation.
According to Meyers, the outer envelopes of the human coronavirus tested and SARS-CoV-2 are genetically similar so the research team hypothesizes that a similar amount of SARS-CoV-2 may be inactivated upon exposure to the solution.
To measure how much virus was inactivated, the researchers placed the diluted solutions in contact with cultured human cells.
They counted how many cells remained alive after a few days of exposure to the viral solution and used that number to calculate the amount of human coronavirus that was inactivated as a result of exposure to the mouthwash or oral rinse that was tested.
The one per cent baby shampoo solution, which is often used by head and neck doctors to rinse the sinuses, inactivated greater than 99.9 per cent of human coronavirus after a two-minute contact time.
Several of the mouthwash and gargle products also were effective at inactivating the infectious virus.
Many inactivated greater than 99.9 per cent of the virus after only 30 seconds of contact time and some inactivated 99.99 per cent of the virus after 30 seconds.
The results with mouthwashes are promising and add to the findings of a study showing that certain types of oral rinses could inactivate SARS-CoV-2 in similar experimental conditions, the study noted.
Recently, a study, published in the Journal of Infectious Diseases, found that Sars-Cov-2 viruses can be "inactivated" using commercially available mouthwashes. (IANS)
London, Aug 11 (IANS) In the fight against the novel Coronavirus, a team of German scientists has claimed that Sars-Cov-2 viruses can be "inactivated" using commercially available mouthwashes.According to the study, published in the Journal of Infectious Diseases, high viral loads can be detected in the oral cavity and throat of some Covid-19 patients.The use of mouthwashes that are effective against Sars-Cov-2 could, thus, help to reduce the viral load and possibly the risk of Coronavirus transmission over a short term, the researchers said."Gargling with mouthwash cannot inhibit the production of viruses in the cells, but could reduce the viral load in the short term where the greatest potential for infection comes from, namely in the oral cavity and throat," said study researcher Toni Meister from Ruhr-Universitat Bochum in Germany.For the findings, the research team tested eight types of mouthwashes with different ingredients that are available in pharmacies or drugstores in Germany.They mixed each mouthwash with virus particles and an interfering substance, which was intended to recreate the effect of saliva in the mouth.The mixture was then shaken for 30 seconds to simulate the effect of gargling.The researchers then used Vero E6 cells, which are particularly receptive to Sars-Cov-2, to determine the virus titer.In order to assess the efficacy of the mouthwashes, the team also treated the virus suspensions with cell culture medium instead of the mouthwash before adding them to the cell culture.All of the tested preparations reduced the initial virus titer, the study said.The findings showed that three mouthwashes reduced it to such an extent that no virus could be detected after an exposure time of 30 seconds.However, the authors maintained that mouthwashes are not suitable for treating Covid-19 but could reduce the viral load in the short term where the greatest potential for infection comes from."Whether this effect is confirmed in clinical practice and how long it lasts must be investigated in further studies," the study authors wrote.--IANSbu/in
London- Commonly-used chlorhexidine mouthwash could make saliva more acidic and increase the risk of tooth damage, according to researchers.
Published in the journal Scientific Reports, the study looked at the chlorhexidine mouthwash's effect on the oral microbiome and found that its use significantly increased the abundance of lactate-producing bacteria that lower saliva pH and might raise the tooth damage risk.
For the study, researchers gave a placebo mouthwash to participants for seven days, followed by seven days of chlorhexidine mouthwash.
At the end of each period, the researchers carried out an analysis of the abundance and diversity of bacteria in the mouth - the oral microbiome - as well as measuring pH, saliva buffering capacity (the ability to neutralise acids in the mouth), lactate, glucose, nitrate and nitrite concentrations.
The research found that using chlorhexidine mouthwash over the seven days led to a greater abundance of species within the families of Firmicutes and Proteobacteria, and fewer Bacteroidetes, TM7 and Fusobacteria.
This change was associated with an increase in acidity, seen in lower salivary pH and buffering capacity, according to the study.
Overall, chlorhexidine was found to reduce microbial diversity in the mouth, although the authors said more research was needed to determine if this reduction in diversity itself increased the risk of oral disease.
"We believe this is the first study to look at the impact of 7-day use on the whole oral microbiome in human subjects," said study lead author Raul Bescos at the University of Plymouth in the UK.
According to the researchers, one of the primary roles of saliva is to maintain a neutral pH in the mouth, as acidity levels fluctuate as a result of eating and drinking. If saliva pH gets too low, damage can occur to the teeth and mucosa - tissue surrounding the teeth and on the inside of the mouth.
The research also confirmed findings from previous studies that chlorhexidine disrupted the ability of oral bacteria to turn nitrate into nitrite, a key molecule for reducing blood pressure.
The findings supported earlier research led by the University that showed the blood pressure-lowering effect of exercise was significantly reduced when people rinsed their mouths with antibacterial mouthwash rather than water. (agency)