New York- Researchers have found that certain metabolites -- small molecules produced by the process of metabolism -- may be the predictive indicators for persons at risk of recurrent major depressive disorder (rMMD).
The findings, published in the journal Translational Psychiatry, indicated that the accuracy of this prediction was more than 90 per cent.
"This is evidence for a mitochondrial nexus at the heart of depression," said the researcher, Robert K. Naviaux, a professor at University of California in San Diego.
"It's a small study, but it is the first to show the potential of using metabolic markers as predictive clinical indicators of patients at greatest risk -- and lower risk -- for recurring bouts of major depressive symptoms," Naviaux added.
rMMD is a mood disorder characterised by multiple symptoms in combination -- feelings of sadness or hopelessness, anger or frustration, loss of interest, sleep disturbances, anxiety, slowed or difficulty thinking, suicidal thoughts and unexplained physical problems, such as back pain or headaches.
For the study, the team recruited 68 subjects (45 females, 23 males) with rMDD who were in antidepressant-free remission and 59 age- and gender-matched controls. After collecting blood from patients who were in remission, the patients were followed prospectively for two-and-a-half years.
Results showed that a metabolic signature found when patients were well could predict which patients were most likely to relapse up to two-and-a-half years in the future.
Analysis of the most predictive chemicals found they belong to certain kinds of lipids (fats that included eicosanoids and sphingolipids) and purines.
Purines are made from molecules, such as ATP and ADP -- the major chemicals used for energy storage in cells, but which also play a role in communications used by cells under stress, known as purinergic signaling.
The researchers found that in subjects with rMMD, changes in specific metabolites in six identified metabolic pathways resulted in fundamental alterations of important cellular activities. (IANS)
For someone affluent with a fast metabolism, preserving a healthy weight is so easy. Better metabolism helps the body burn calories more instantly and stops weight gain. But not all of us are lucky sufficient to be gifted with a naturally fast metabolism.
People with gentle metabolism increase weight immediately and even find it hard to shed kilos. Fortunately, there are some foods that can help to boost metabolism and speed up weight loss procedures. If you are among those who are scrambling to shed kilos then it is time to mention these vitamins and minerals in your routine diet.
There are some general nutrients:
When it applies to boosting metabolism, one cannot ignore this nutrient. A low level of iron in the blood indicates shortness of oxygen will be shipped to the muscles. This obstructs the fat burning procedure and tampers with the metabolic rate. It is an important nutrient required for healthy growth, development, and boosting metabolism. Some usual roots of iron are almonds, soybeans, fish, and meat.
2. Vitamin B
Vitamin B makes sure that all the food you eat is consumed for generating energy and is not contained in the body as fat. Be it protein, fat, or carbs, this nutrient can help metabolize all kinds of food. The reduction of this nutrient often outrages metabolism and indicates weight gain. Except, it can also prompt your mood. Lean meat, whole-grain, banana, apple, spinach, and dairy are some bases of Vitamin B.
Various studies recommend that calcium can help to control blood sugar levels and boost metabolism. It is argued that the nutrient can flabbily enhance the core temperature of the body, called the thermogenesis result. This may boost metabolism and indicate our bodies to burn fat. almonds, seeds, and Dairy products should be a part of your diet if you want to enhance calcium consumption.
Magnesium plays an important role in chemical responses that take place to produce energy. In the absence of this nutrient, our metabolism and the procedure of energy production slows down. Different from this, magnesium is needed for more than 300 enzymatic responses that help the brain function and support muscles to calm. normal roots of magnesium are nuts, legumes and potatoes, and seeds.
5. Vitamin C
Vitamin C is another classic mood and metabolism-boosting nutrient. As per some studies, Vitamin C can help to fight oxidative stress, which quiets down the metabolic rate of the body. People who lack this nutrient have a hard time losing kilos. oranges, lemon, and tomatoes are some usual roots of vitamin C rich food.
This content loaded with advice gives general information only. It is in no way a change for an eligible medical view. Always consult with an Ayurveda doctor for more information.
Ayurveda is the answer to all your sleep-related problems. The Ayurvedic take on sleep is more holistic and provides natural solutions too. If you do not follow an ideal Ayurvedic dincharya, the chances of having disturbed sleep will be much higher. Let us look at a few causes of disturbed sleep metabolism as per Ayurveda.
Also, Read► Ayush Ministry's Webinar on Yoga and Sleep
Causes Of Disturbed Sleep Metabolism
No daily routine
If your daily routine is not coordinated with the natural Ayurvedic cycles then sleep metabolism will be greatly affected. Most people do not have an ideal Ayurvedic Dincharyas. Some people even have erratic schedules. They neither eat nor sleep on time. This can create problems with the sleep-wake cycle. It slowly becomes a pattern.
Most people are consuming diets that are high in fats and carbohydrates and lack basic nutrition. A nutritional deficiency can easily be associated with a lack of sleep or poor sleep quality. If you keep consuming high doses of caffeine and sugars, sleep will be affected. It will make the body lethargic but would not help in getting proper sleep. Alcoholic beverages may have similar effects.
If you have been trying to lose weight with fad diets, poor sleep will become a common problem for you. This is because a fad diet will make you consume significantly lesser calories than what you are habitual of. Your body will take this as a signal for starvation and will start storing more calories as fat. Consequently, your body will only gain weight. while this is happening, your brain is trying too hard to keep everything in the body in working order. It is on panic mode. Your sleep is disturbed thus.
Stress can make your body enter a chronic panic mode. this has similar effects to the starvation mode. Your body goes into adrenal fatigue as it is constantly on the flight or fight mode. This makes the hormone cortisol go into overdrive. It can make your sleep habits erratic, result in poor sleep quality or a total lack of sleep in extreme cases.
Improving the quality of sleep and making the sleeping metabolism better is easy if you follow a few ayurvedic rules. all you must do is audit your dincharya and then find the best solutions possible for better sleep. The Ayurvedic remedies for better sleep are simple and very easy to perform too.
Also, Read► Having trouble sleeping? It could be a sleep disorder
How to Get Better Sleep with Ayurveda
Sleeping for 8 hours a day is considered ideal. If you follow the sleep rhythms, then sleeping for exactly 7.5 to 9 hours will leave you fresh and rejuvenated in the morning. It will help break down fats and sugars faster and will improve any conditions related to hormones as well. Stress, anxiety, and panic will also take a sideline in your life.
Make an Ayurvedic Dinacharya
An Ayurvedic Dinacharya follows the basic principles of Vata, Pitta, and Kapha. All three doshas will rule certain times of the day and make you more capable of performing certain tasks associated with them. For example, the time between 2 and 6 am in the morning is perfect for movement. Most creative people stay awake during this time as Vata elements help in the movement of their creative energies. People who have a dysfunctional Vata, often wake up during this time in the night and are then unable to fall asleep because of racing thoughts.
It is ideal to sleep at 10 pm and wake up at 6 am. The pitta energy that dominates from 10 pm to 2 am will help in digestion of your dinner, speeding up your metabolism and detoxification of the body. The Vata period running from 2 am to 6 am will help in the removal of toxins or ama from the body. In the morning, you wake up refreshed and rejuvenated.
Using ghee for massage
If you cannot fall asleep on time, you must massage the soles of your feet with ghee just before bedtime. This massage will stimulate sleep and help you sleep comfortably throughout the night. You will most likely wake up refreshed, before dawn, if you massage your feet well. The calming properties of the ghee massage will help you relax. People who are continuously stressed must try this remedy for better sleep.
Avoid sugary or processed foods just before bedtime
Your dinner should not be composed of sugary or processed food. Avoid snacking after dinner as well. Sugar can easily interrupt your sleep metabolism and make you feel lethargic but not sleepy. Therefore, you will not be able to sleep properly. Even if you fall asleep, you will feel groggy and dull. Hence, it would be wise to avoid any sugary and processed foods. You must also not have fruits or fruit juices before sleeping. Stick to simple carbohydrates and simply cooked vegetables or meats.
An Abhyangam massage done with oils that suit your body type could be the only thing you might need for proper sleep. Simply take oil of your choice and start massaging your body with it slowly. Make sure that you use firm but soft strokes on your body. Take ample oil that can be absorbed in your body. People with dry skin will need more oil than others and they must be generous with the application. Slowly massage the entire body and relax. It helps in relieving the stress and muscular tensions in your body. you can relax and get better sleep too.
These simple ayurvedic remedies will help you in getting the best sleep possible. Remember, the most important ayurvedic principle to follow is Dincharya. If you do not opt for a good dincharya, then you will certainly have problems related to sleep and digestion which will lead to further health troubles. These small and simple tasks will help in removing sleep problems from your life completely but if the problem persists, you can talk to an ayurvedic doctor. find local, qualified and verified doctors on Nirog Street and book an appointment immediately.
Read More► India is sleeping less