Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, finds a new research.
The study, completed in an animal model, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function.
MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue).
"This research promotes the concept that MDSC expansion during obesity to become osteoclasts during periodontitis is tied to increased alveolar bone destruction," said researcher K.H. Kwack from the University at Buffalo.
"Taken together, this data supports the view that obesity raises the risk of periodontal bone loss," Kwack added.
Bone loss is a major symptom of gum disease and may ultimately lead to tooth loss.
Also known as periodontal disease, gum disease affects more than 47 per cent of adults 30 years and older, according to the Centers for Disease Control and Prevention.
For the study, published in the Journal of Dental Research, the team examined two groups of mice fed vastly different diets over 16 weeks -- one group, a low-fat diet that derived 10 per cent of energy from fat, the other group a high-fat diet that drew 45 per cent of energy from fat.
The investigation found that the high-fat diet group experienced obesity, more inflammation and a greater increase of MDSCs in the bone marrow and spleen compared to the low-fat diet group.
The high-fat diet group also developed a significantly larger number of osteoclasts and lost more alveolar bone (the bone that holds teeth in place).
Also, the expression of 27 genes tied to osteoclast formation were significantly elevated in the group fed a high-fat diet.
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Migraine is a debilitating neurological disease, ranking consistently among the top 10 leading causes of years lived with disability, worldwide. The main symptom of migraine is an enduring headache, along with symptoms such as severe pain on one side of the head or throbbing pain, sensitivity to light and sound, and nausea. Despite being a very common headache disorder that affects roughly 15 percent of the adult population worldwide, it remains inadequately understood and most neglected.
In Delhi, approximately 25 per cent of the population suffers from migraines, every year.
While migraine is an invisible condition, it can severely impact individuals across personal, professional and social domains, thus affecting the overall quality of life and productivity. Work-from-home, or the 'new normal,' has drastically impacted the lives of people suffering from migraines from an inability to concentrate at work to missed workdays. It has become even more urgent to ensure that individuals have the understanding and tools to effectively manage migraines.
There is a lack of understanding amongst people about the severity of migraines. In a study we recently conducted, about 50 to 60 per cent of migraineurs were undiagnosed, despite recurrent headaches. Because migraine falls on a spectrum, ranging from infrequent or mild attacks to recurrent ones, many pass it off as merely a headache'. With busy work-from-home schedules, paired with fear of contracting COVID-19 infection and difficulty in accessing in-person care, people are avoiding seeking medical help for the condition, instead attributing symptoms to associated comorbidities, such as stress or depression."
He continued, "Financial worries due to job loss or salary cuts also contribute to aggravated migraine attacks, which is more noticeable recently. The effects of migraine on one's quality of life also reportedly worsened, particularly for many migraineurs working as essential healthcare workers at this time.
Symptom neglect and failure to treat the condition can lead to migraines becoming chronic. A fundamental need is to recognize migraine as a serious condition with severe disability and adopt a holistic treatment approach. Early detection can be a key enabler of a smoother patient journey and an improved quality of life."
Here are 5 ways to manage your migraine while working from home:
Identify Risk Factors and Monitor Triggers
Migraines can begin at any age but tend to peak during one's prime productive years. Moreover, women are three times more likely to be affected than men, with prevalence peaking between the ages of 25 and 55 years.
Long hours of working from home, along with longer screen times, disrupted sleep schedules and irregular eating habits can increase stress levels. For migraineurs, such changes can become migraine triggers, exacerbating their condition. Identifying personal triggers can help individuals manage their migraines better.
Make The Right Choice for Diet and Lifestyle
Working from home can be hard, but a daily routine that optimizes your physical and mental health can help keep your migraine at bay. Eating healthy meals at appropriate times or consuming small, frequent meals throughout the day are associated with less frequent migraine headaches. Taking breaks from work at regular intervals can help you eat right and reduce eye strain owing to excessive screen use. Making modifications to your lifestyle, including smoking cessation and reduced alcohol consumption, and maintaining optimal sleeping habits and exercising regularly can be key to manage migraines. These also benefit migraine prevention and treatment.
Talk to An Expert
It is important to consult a medical specialist when you are experiencing severe headaches that disrupt your daily routine. A lot of migraineurs hesitate to seek medical help. This could be due to several reasons lack of understanding of migraine severity, lack of time due to hectic work-from-home schedules, or recently, due to a reduction in-person clinic consultations owing to the fear of Covid-19 infection. However, consulting a neurologist, even via teleconsultations, is a necessary step to diagnose your condition and understand the available options for acute and chronic management of migraine, including preventive treatment. With evidence-based information on effects across migraine intensity reduction, quality of life and ease of use, neurologists can guide you on the most suitable treatment option to prevent or reduce your migraine episodes.
Track Your Migraines
It is a good idea to maintain a diary (or download a migraine tracker app), to record the time and severity of your migraine attacks, symptoms, daily diet, exercise routines, and medications and side effects. This can help identify triggers and patterns. It can also prompt meaningful conversations with your doctor, contributing to a more holistic treatment plan, personalized to suit your work schedule.
Seek Support From Your Family, Friends or Colleagues
Living with migraines can make one feel helpless, distressed and misunderstood. But talking to your friends and family will help them understand your condition better. Having an open conversation about your migraine with your employer is a good idea, particularly to work out a schedule, with specific routine adjustments to mitigate triggers. This can help you be productive and healthy while working from home. Employers can also take the initiative -- arranging wellness programs for employees to raise awareness about migraines and how to effectively manage them at work and enhance productivity.
Migraine attacks can be challenging. Changes to your daily routine and active communication about your condition with your employer, after consulting a neurologist, can help you better manage migraines as you work from home.
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Lucknow, April 26 (IANS) Sudden fatigue with a sudden drop in platelets in blood is also a symptom of Covid-19 in initial stages, while fever and extreme breathlessness develops later.According to medical experts, if ignored, these initial symptoms could prove to be fatal.Prof Santosh Kumar, respiratory medicine department KGMU, said, "In every viral infection, platelet count drops. Therefore, one should not ignore fatigue and exhaustion and get themselves tested for Covid-19."Although, general Influenza-like symptoms are common in Covid-19 but new symptoms are diarrhoea, red eyes, rashes and fatigue.Dr Vikram Singh, faculty at department of medicine in Ram Manohar Lohia Institute of Medical Sciences, said, "Extreme fatigue and malaise are among the symptoms of viral fever. And since, Covid is also a type of viral people can experience both the symptoms with fever in Covid also. In a normal person platelet count ranges between 1.5 lakh to 4.5 lakh per litre of blood but in some of the cases, it is seen that the platelet count has reached 75,000 to 85,000 per litre. This low platelet count sometimes is mistaken by the patients as dengue or other diseases. We suggest if a person is feeling exhausted and extremely tired. They must get tested for Covid-19."Medical experts in Lucknow said that there have been over a dozen cases where the patients experienced extreme fatigue but did not consult a doctor.When their condition worsened, the blood test showed a drastic drop in platelet count. The patient then developed breathing problems and died without oxygen support.--IANSamita/in
Hyderabad- Granules India Ltd on Wednesday announced that the US Food & Drug Administration (US FDA) has approved its Abbreviated New Drug Application (ANDA) for acetaminophen, aspirin, and caffeine tablets, indicated for the treatment of migraine.
It is bioequivalent to the Reference Listed Drug (RLD) product, Excedrin Migraine tablets, 250 mg/250 mg/65 mg, of GlaxoSmithKline Consumer Healthcare.
The product would be manufactured at Granules India's Hyderabad facility and is expected to be launched shortly.
"We are pleased to announce approval of Acetaminophen, Aspirin and Caffeine tablets, emphasising our focus on building a sustainable OTC product portfolio in the US market. We received approval for this triple combination product within 14 months from filing. With this, we have received three ANDA approvals over the past month." said Priyanka Chigurupati, Executive Director, Granules Pharmaceuticals, Inc.
Granules now has a total of 38 ANDA approvals from US FDA (37 Final approvals and 1 tentative approval). Excedrin is a trademark of GSK Consumer Healthcare S.A. (IANS)
कुछ समय पहले, ब्रिटेन में जनरल फिजिशियन के एक समूह ने दावा किया था कि सामान्य सर्दी के लक्षणों को हल्के में नहीं लेना चाहिए, बल्कि इसे कोरोनावायरस का लक्षण मानना चाहिए, लेकिन इसे लेकर एक अलग नजरिया भी है।
एम्स की भोपाल और जम्मू इकाई के प्रेसीडेंट वाई.के. गुप्ता ने आईएएनएस को बताया कि खांसी, बुखार और सामान्य सर्दी को कोरोनावायरस के संकेत के रूप में 100 प्रतिशत नहीं माना जा सकता।
कथित तौर पर, 140 ईस्ट लंदन के जनरल प्रैक्टिशनर्स (जीपी) और हेल्थ केयर पेशेवरों ने इंग्लैंड के मुख्य स्वास्थ्य अधिकारी क्रिस व्हिट्टी और पब्लिक हेल्थ की सुजन हॉपकिंस को एक खुला पत्र लिखा था और दावा किया था कि मरीजों को कोरोना पॉजिटिव होने के पहले आमतौर पर गले में खराश, नाक बहना, सिरदर्द जैसे सामान्य सर्दी के लक्षण अनुभव होते हैं।
एम्स नई दिल्ली के फार्माकोलॉजी विभाग के पूर्व प्रमुख गुप्ता ने कहा, सामान्य सर्दी कोरोनोवायरस का 100 प्रतिशत संकेत नहीं हो सकती। अधिकांश सामान्य सर्दी वायरल संक्रमण गिरावट पर हैं, लेकिन इसका मतलब यह नहीं है कि लोगों को लापरवाही करनी चाहिए। मास्क पहनना और सोशल डिस्टेंसिंग बनाए रखना आवश्यक है।
गुप्ता ने चेतावनी दी कि हाल ही में कोविड के मामलों में कमी आई है, लेकिन इसका मतलब यह नहीं है कि खतरा टल गया है। उन्होंने कहा कि मामलों और मौतों में गिरावट के लिए योगदान करने वाले कारकों में टीकाकरण अभियान और देश में लोगों की आंतरिक प्रतिरक्षा हो सकती है।
उन्होंने कहा, एक बड़ी आबादी पहले से ही संक्रमित हो गई है, जो सबक्लिनिकल रूप से गिरावट में योगदान कर सकती है। इस की रोगजनकता शायद कम हो रही है।
पश्चिमी देशों में बढ़ती संख्या और भारत में मामलों में लगातार गिरावट के पहलू पर, गुप्ता ने संकेत दिया कि यह संभवत: पश्चिमी आबादी की तुलना में वायरस के प्रति भारतीय आबादी की उच्च प्रतिरक्षा के कारण है, लेकिन इसे साबित करने के लिए पर्याप्त डेटा नहीं है।
जिन लोगों ने कोविड-19 से संक्रमित होने के बाद टीका लगवाया, उनमें कुछ स्वास्थ्य चीजें विकसित हुई हैं। क्या यह एक लास्टिंग हेल्थ समस्या बनने की क्षमता है? गुप्ता ने उत्तर दिया कि यह एक रिजिडूअल स्वास्थ्य समस्या हो सकती है और वैक्सीन रिजिडूअल साइड-इफेक्ट नहीं है, वास्तव में टीकाकरण के बाद एलर्जी की प्रतिक्रिया दो दिनों से अधिक नहीं रहती है।
यह पूछे जाने पर कि किसी विशेष आयु समूह खासकर बुजुर्गो या कॉमरबिडिटिज को लेकर उनके सामने कोई सुरक्षा संबंधी मुद्दा आया है तो गुप्ता ने कहा कि अभी तक तो नहीं आया है, क्योंकि डेटा पूरी तरह से उपलब्ध नहीं है और कहा कि कोवैक्सिन के तीसरे चरण के ट्रायल के बारे में डेटा शायद मार्च के अंत तक उपलब्ध हो, जो इसकी प्रभावकारिता साबित करेगा। (एजेंसी)
Canberra- A new research by Australia's Griffith University has found cancer, chronic kidney disease, diabetes and hypertension are the four main comorbidities leading to Covid-19 deaths.
After analysing global databases of 375,859 participants from 14 countries, researchers from the University found chronic kidney disease was statistically the most prominent comorbidity linked to death, reports Xinhua news agency.
They also found hypertension, obesity and diabetes were the most common underlying medical conditions in Covid-19 patients.
However, unlike the other two comorbidities, obesity did not increase the risk of mortality.
"Comorbidities are frequently cited as risk factors for severe COVID-19 outcomes, however, the degree to which specific comorbidities impact the disease is debatable," said co-lead author Adam Taylor.
"This is a global study covering all comorbidities reported to be involved in the exacerbation of COVID-19 leading to death. It allows us to identify specific comorbidities that have higher risk in patients and identify COVID-19 high-risk groups."
Lead author Professor Suresh Mahlingam said Covid-19 was associated with increased clot strength, so patients with hypertension and diabetes could have a higher risk of developing life-threatening thrombotic complications.
For Covid-19 patients with chronic kidney disease, the risk of mortality was higher in cases with end-stage renal disease compared to chronic renal disease.
The researchers said further investigation is required to explain the higher prevalence of these comorbidities in infected patients. (agency)