An Ayurvedic poly-herbal formulation, NEERI-KFT, has the potential to not only slow down the progression of chronic kidney disease but also restore normalcy in functional parameters of the vital organ, a team of researchers has claimed.
In a review published in the latest edition of Saudi Journal of Biological Sciences, they said "phytopharmacological evaluation of NEERI-KFT suggests that it exhibits substantial potential against oxidative and inflammatory stress induced apoptosis by exerting antioxidant, nephroprotective and immunomodulatory effects...in the patients associated with renal dysfunction or chronic kidney disease (CKD)".
The NEERI-KFT, a herbal medicine extracted from plants, has been found to correct oxidative as well as inflammatory stress known for reducing body's immunity, said the authors after drawing data on the formulation for kidney ailments from more than five electronic databases such as Science Direct, Google Scholar, Elsevier, PubMed, Springer, ACS publication from published database between 2000 and 2020.
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The study, 'A systematic review on nephroprotective AYUSH drugs as constituents of NEERI-KFT' not only examined the impact of the herbal extract of NEERI-KFT prepared by the AIMIL Pharma interventions on patients, but also dwelled in detail the adverse events of the modern medicine used for the management of the kidney ailments.
The study also highlighted the herbal drug's efficacy in reducing "serum creatinine, blood urea, and serum uric acid as compared to placebo group" and described "its well-tolerated effect with no adverse hematological or biochemical abnormalities occurred to any subjects during clinical trial".
"It can be suggested that NEERI-KFT can be an alternative and complementary therapy at end-stage renal disease (ESRD) or complete loss of kidney function where frequent dialysis of renal transplant remains only a single option for continued survival CKD patients," researchers said.
K.K. Sharma, AIMIL Pharma Managing Director, attributed this to the "more than 20 different potent herbs like haridra, varuna, shirish, gokhru, punarnava and anantamul to name a few in the formulation which are known for their nephro corrective, anti-inflammatory and antioxidant properties and reparative regeneration of kidney cells.
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It was after a string of stringent tests that this formulation has been developed to provide relief to kidney patients, he said.
K.N. Dwivedi from Banaras Hindu University said the herbal ingredients in NEERI-KFT are loaded with many anti-oxidants besides medicinal values which not only strengthen kidney but liver also.
"This is a very unique drug and we have found it very effective in our study also," he added.
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Washington, Aug 11 (IANS) The US National Institutes of Health (NIH) has launched a pilot study to assess the antibody response to a third dose of a Covid-19 mRNA vaccine in kidney transplant recipients who did not respond to a two-dose shot of Moderna or Pfizer-BioNTech.The pilot study, called Covid Protection After Transplant (CPAT), will be conducted at Johns Hopkins University in Baltimore, US. The team will enrol up to 200 adults aged 18 years or older who received a kidney transplant a year or more prior to enrolment and have had no recent organ rejection or change in immunosuppression, the NIH said in a statement. The lifelong immunosuppressive therapy that organ transplant recipients must take to prevent organ rejection blunts their immune response to both pathogens and vaccines. Research has shown that many organ transplant recipients do not develop antibodies against SARS-CoV-2, the virus that causes Covid-19, after receiving Covid-19 vaccines. The study aims to determine whether a third dose of one of the mRNA Covid-19 vaccines could overcome this problem for at least some kidney transplant recipients. This is particularly important because this population has a high prevalence of conditions that are risk factors for severe Covid-19, such as cardiovascular disease and diabetes.The pilot study also aims to identify characteristics that could help distinguish those kidney transplant recipients who would benefit from a third dose of an mRNA vaccine from those who will require a different approach to achieve protection. The third-dose vaccine intervention was chosen because of the demonstrated safety of the two-dose mRNA vaccine regimen in solid organ transplant recipients as well as the efficacy of additional doses of other vaccines, such as those for hepatitis and influenza, in immunocompromised people, the NIH said.The study participants will be followed for one year after enrolment. Preliminary results are expected in September 2021.--IANSrvt/bg
Noida, Aug 5 (IANS) A 80-year-old mother has donated her kidney to save the life of her son, displaying the epitome of love and sacrifice. The case has entered the India Book of Records for the 'aged living female kidney donor'.Madeleine, a farmer from Cameroon (Gulf of Guinea, Central Africa), donated a kidney to her son Joseph, 52, who was suffering from a prolonged kidney disease resulting in kidney failure. A team of doctors at Jaypee Hospital successfully conducted the highly complicated kidney transplant surgery, the hospital said in a statement on Thursday."Madeleine's old age was of a major concern for us as mostly the health of the kidney starts deteriorating after the age of 65. After proper evaluation, it was found that she had good kidney functions and was found medically fit to donate her kidney," said Amit K Devra, Director, Coordinator Kidney Transplant Programme, Department of Urology and Kidney Transplant at Jaypee, which has successfully completed more than 650 kidney transplants. "However, she had a complex kidney anatomy with two renal arteries and two ureters for which we had to connect two tubes instead of one for the proper renal functioning," said Amit K Devra, Director, Coordinator Kidney Transplant Programme, Department of Urology and Kidney Transplant at Jaypee, in a statement. "Generally, normal people have one renal artery and ureters. A small stone was also diagnosed in her kidney. This made the process even more complicated, but without any hesitation, we took up the challenge in order to save our patient's life," he added. Madeleine's kidney harvesting was done laparoscopically to reduce the post-operative pain. After kidney removal, the stone was removed (ex vivo) while the kidney was in an ice bucket for perfusion. Both renal arteries were then connected separately with the recipient's blood vessels, the doctor said."It takes an incredible amount of strength, endurance and faith to donate a kidney at this age. She did not lose hope and her strong will to save her son's life pushed her to not give up at any point. The donor was discharged on the fifth post-operative day, whereas the recipient was discharged on the eighth post-operative day," said Dr Vijay K Sinha, Associate Director, Department of Nephrology and Kidney Transplant at the hospital.The team of doctors who successfully conducted the complicated kidney transplant surgery had Dr Devra, Dr Sinha, Dr LP Chowdhury, Dr Ravi Singh, Dr Anuj Arora, Dr Khushboo Singh and other paramedical staff.--IANSrvt/na
Bhubaneswar, July 12 (IANS) On the occasion of the Rath Yatra, Odisha Chief Minister Naveen Patnaik on Monday laid the foundation for two state-of-the-art cancer care institutions here at Infovalley.He laid the foundation stone for Bagchi-Sri Shankara Cancer Hospital & Research Centre and for Bagchi-Karunashraya Palliative Care Centre. Odisha Skill Development Authority (OSDA) chairman Subrato Bagchi and his wife Sushmita have donated Rs 340 crore for the establishment of these two cancer-care institutions.While Sri Shankar Foundation will run the 750-bed cancer hospital, Bengaluru-based hospice foundation will run the palliative care unit.The palliative care unit will have 110 beds and will provide free service.Addressing a gathering on the occasion, Patnaik said that both the institutions will help the patients of Odisha, especially the poor in accessing quality health care facilities. He assured that the state government will provide all support for its early completion.He congratulated the Bagchi couple for their philanthropy and noble efforts to create two world-class institutions in Odisha. Their philanthropy is an inspiration for Odisha and the people will remember them for their contribution, he stated.Sri Shankara Cancer Foundation, led by Dr Srinath, is setting up the cancer hospital which will work on a cross-subsidy model, he said."I am very happy to learn that the hospital will now be 750 beds with the latest technology. I am sure this centre will become the leading research institution and attract oncologists from across the world to serve humanity," Patnaik added.The chief minister informed that Kishore Rao and Gurmeet Randhawa, founders of Bangalore Hospice Trust and their team have been serving the dying for over 25 years through their Karunashraya."We are happy that such a kind institution providing world-class palliative care is now being set up in Odisha. It's heartening to note that world class palliative care would be completely free of cost," the chief minister said.Joining the programme, Dr Srinath said that the hospital will be a one stop cancer centre with all the treatment facilities including bone marrow transplantation. The hospital will have a PG Training facility on oncology, he added.Randhawa said that the palliative centre in Bhubaneswar will be developed as the best palliative care facility in the world. They will train over 25,000 youth, including tribal girls, in the next five years.--IANS bbm/skp/bg
As the second Covid wave leaves India devastated amid the third wave warning, those who were severely hit by the deadly respiratory disease must also keep the health of their kidneys in check, top health experts advised on Friday.
A latest AIIMS study has confirmed that apart from the lungs and liver, kidneys were the most affected in deseased patients with severe Covid-19.
According to Dr Amit K Devra, Senior Kidney Transplant Surgeon at Jaypee Hospital in Noida, low oxygen level in blood because of pneumonia can produce ATN (damage to tubule) in kidney.
"In severe cases, because of cytokines storm, there is severe immune reaction leading to intense inflammation of multiple organs including kidney, causing damage to healthy kidney," Devra told IANS.
The full impact of COVID-19 on the kidneys isn't yet clear yet.
However, C John Sperati, an expert in kidney health from Johns Hopkins Medicine, has revealed how the new coronavirus might affect kidney function as the illness develops and afterward as a person recovers.
The virus itself infects the cells of the kidney. Kidney cells have receptors that enable the new coronavirus to attach to them, invade, and make copies of itself, potentially damaging those tissues.
"Similar receptors are found on cells of the lungs and heart, where the new coronavirus has been shown to cause injury," Sperati, also Director, Nephrology Fellowship Training Programme, said in a latest update published on Johns Hopkins website.
Another possibility is that kidney problems in patients with the coronavirus are due to abnormally low levels of oxygen in the blood, a result of the pneumonia commonly seen in severe cases of the disease, he added.
The kidneys are like filters that screen out toxins, extra water and waste products from the body.
"Covid-19 can cause tiny clots to form in the bloodstream, which can clog the smallest blood vessels in the kidney and impair its function," according to Sperati.
Some people suffering with severe cases of Covid-19 are showing signs of kidney damage, even those who had no underlying kidney problems before they were infected with the coronavirus.
Early reports say that up to 30 per cent of patients hospitalised with Covid-19 in China and New York developed moderate or severe kidney injury.
According to Dr. Anuja Porwal, Additional Director, Nephrology, at Fortis Hospital, majority of the times, the damage is reversible and sometimes, it is partially reversible and sometimes, it is not reversible.
"If a person has underlying co-morbidities like diabetes, hypertension, heart disease, kidney stones etc, he/she is more susceptible to having kidney issues.
Additionally, sometimes, the drugs given for treatment of Covid can have an impact on the kidney as well," Porwal told IANS.
If a patient has had kidney involvement during Covid infection, he/she should definitely get their kidney function test and follow up with a nephrologist regularly at least upto three months, the experts advised. (IANS)
Shimla, May 31 (IANS) BJP President J.P. Nadda on Monday virtually laid the foundation stones for two oxygen plants with a capacity of 140 litres per minute each in Himachal Pradesh in the presence of Chief Minister Jai Ram Thakur and Union Minister of State for Finance Anurag Thakur.The plants will be commissioned at the Dr Radhakrishanan Government Medical College in Hamirpur and at the Community Health Centre in Ghumarwin in Bilaspur district. Each plant would provide oxygen supply to 30 beds.While addressing the event from New Delhi, Nadda, who belongs to the hill state, said when most of the national political parties have gone under "virtual quarantine", the BJP through its "Sewa Hi Sangathan" has come forward to help the people of the state fight the pandemic.He said the Union government under the leadership of Prime Minister Narendra Modi has provided free ration to about 80 crore people of the country during both the first and second wave of the pandemic.Nadda said 926,963 eligible farmers of the state have been provided an assistance of Rs 1355.80 crore under the Pradhan Mantri Kisan Samman Nidhi Yojna till now.The BJP President also said that there was only one virology lab to test coronavirus in the country last year, but now India has over 2,500 labs, providing immediate testing facilities to the patients.He also appreciated Union Minister of State for Finance Anurag Thakur for helping Himachal fight the pandemic.Chief Minister Jai Ram Thakur said that on March 1, the state had only 11 dedicated Covid hospitals and health centres with a bed capacity of 440. The state has added 46 more facilities with a bed capacity of around 3,500 and more than 250 ICU and ventilator beds.He said the three makeshift hospitals at Khaliyar in Mandi district, Paraur in Kangra district and Rabon in Solan district have increased the bed capacity to 5,000.The Chief Minister said the state has administered 23.59 lakh doses of vaccine so far and it is one of the few states to achieve zero per cent wastage of vaccines.He also thanked Anurag Thakur for his generous contribution to the state in fighting the pandemic.On his part, Anurag Thakur said that it was due to the initiative of party President J.P. Nadda that each and every BJP functionary contributed generously towards helping Covid-19 patients and their families.Stating that not even a single PPE kit was produced in country when the pandemic broke out last year, Anurag Thakur said, "Today the nation is producing about 20 lakh PPE kits per day."He said that 23 crore doses of vaccine have been administered to the people across the country.The MoS for Finance also said that an oxygen bank would be set up in Himachal Pradesh which would provide oxygen to 700 beds.--IANSvg/arm