सैन डिएगो| लैंसेट पत्रिका में प्रकाशित एक अध्ययन में दावा किया गया है कि वयस्कों में क्रॉनिक किडनी रोग (सीकेडी) से पीड़ित कुछ लोगों के इलाज के लिए एक आम मधुमेह की दवा का इस्तेमाल किया जा सकता है। डैपाग्लीफ्लोजिन 'सोडियम ग्लूकोज कोट्रांसपोर्टर-2 (एसजीएलटी2) इनहिबिटर' नामक दवाओं के एक समूह से संबंध रखता है।
एसजीएलटी2 अवरोधक गुर्दे में एसजीएलटी2 प्रोटीन को अवरुद्ध करके काम करता है। इस प्रोटीन को अवरुद्ध करने से गुर्दे में दबाव और सूजन को कम करके गुर्दे की क्षति को कम किया जा सकता है। यह प्रोटीन को मूत्र में रिसने से रोकने में भी मदद करता है, और रक्तचाप और शरीर के वजन को कम करता है।
सीकेडी के साथ 4,304 प्रतिभागियों के नैदानिक परीक्षण से पता चला है कि डैपाग्लिफ्लोजि़न क्रॉनिक किडनी रोग (सीकेडी) के रोगियों में गुर्दे के कार्य में गिरावट की दर को कम करता है।
हालांकि मधुमेह के बिना प्रतिभागियों ने भी डैपाग्लिफ्लोजि़न के साथ गुर्दा समारोह में गिरावट की धीमी दर का अनुभव किया, क्योंकि मधुमेह वाले लोगों में डापाग्लिफ्लोजि़न का प्रभाव अधिक था।
यूनिवर्सिटी मेडिकल सेंटर ग्रोनिंगन के प्रमुख लेखक हिड्डो लैम्बर्स हीर्सपिंक ने कहा, "मुख्य निष्कर्ष यह है कि डैपाग्लिफ्लोजि़न सीकेडी के साथ और बिना टाइप 2 मधुमेह के रोगियों में प्रगतिशील किडनी फंक्शन लॉस को धीमा करने के लिए एक प्रभावी उपचार है।"
हीर्सपिंक ने कहा, "इसलिए, हार्टफेल या मृत्युदर के जोखिम को कम करने के अलावा, डैपाग्लिफ्लोजि़न भी गुर्दे के कार्य में गिरावट की प्रगति को धीमा कर देता है।"
शोध के निष्कर्ष 'एएसएन किडनी वीक 2021' के 4-7 नवंबर अंक में भी प्रस्तुत किए जाएंगे। (एजेंसी)
London, Sep 7 (IANS) Covid-19 infection does not appear to affect the lung function of young adults, according to new research presented at the European Respiratory Society International Congress on Tuesday.The study, by researchers at the Karolinska Institute in Stockholm, Sweden, found that even patients with asthma did not show a statistically significant deterioration in lung function.However, there was a trend towards slightly lower measurements for the amount of air they could exhale forcibly in one second, known as forced expiratory air volume in one second (FEV1), which is one of the measures of lung function."Our analysis showed similar lung function irrespective of Covid-19 history," said Ida Mogensen, a post-doctoral student at Karolinska."When we included 123 participants with asthma in the analysis, the 24 per cent who had had Covid-19 tended towards having a slightly lower lung function, but this was not statistically significant," she added.The team gathered information from 661 young people with an average age 22 years, between October 2020 and May 2021.Collected data included measurements of lung function, inflammation and white blood cells called eosinophils, which are part of the immune system.Of the 661 participants, 178 (27 per cent) had antibodies against SARS-CoV-2 indicating they had been infected.The researchers measured FEV1, FVC (forced vital capacity, which represents the volume of air in the lungs that can be exhaled after a taking the deepest breath possible), and FEV1/FVC ratio, which is an indicator of narrowed airways.They calculated the changes in lung function between the period before the pandemic and during the pandemic. Then they compared the percentage change with participants who had not been infected.There was no difference in lung function among patients who had had Covid-19 with respect to eosinophils, indicators of inflammation, allergy responses or use of inhaled corticosteroids."These results are reassuring for young adults. However, we will continue to analyse data from more people. In particular, we want to look more closely at people with asthma as the group in this study was fairly small. We are also curious as to whether the length of time after the infection is important, as well as the severity of disease and symptoms," Mogensen said.In a separate study, presented at the congress on Sunday, researchers showed that the lung function in children and adolescents was mildly impaired only in those who experienced a severe Covid-19 infection.--IANSrvt/ksk/
London, Sep 6 (IANS) People who have modestly but measurably worse lung function are more likely to suffer sudden cardiac death (SCD), according to research presented at the European Respiratory Society International Congress.SCD is an unexpected death that results from a sudden malfunction in the heart and in many people who suffer SCD, there are no previous warning signs. Researchers hope their findings could help spot people at risk of SCD and prevent deaths in the future.The team at Lund University in Sweden studied a group of 28,584 middle-aged people with no known heart problems who were living in Malmo, Sweden and followed them for 40 years.They found that measurably lower lung function in middle-aged people was more strongly related to suffering a SCD (a 23 per cent increase in risk) than a non-fatal coronary event (an 8 per cent increase in risk) later on in life."Although sudden cardiac deaths are common, we don't know enough about who is at risk in the general population. There are links between lung and heart health, so we wanted to investigate whether measurable differences in lung function could offer clues about the risk of sudden cardiac death," said Dr Suneela Zaigham, researcher at the Department of Clinical Sciences at Lund University, Sweden."Our findings suggest that testing people's lungs when they are middle-aged and healthy could help spot those who have a higher risk of sudden cardiac death. This could enable people to take steps to potentially reduce the risk of this devastating event," Zaigham added.Smoking is also known to affect both lung and heart health, however the pattern of risk remained even in people who had never smoked, Zaigham said."This study suggests a link between lung health and sudden cardiac death. It shows a higher risk of fatal than non-fatal coronary events even in people whose lung function is moderately lower but may still be within a normal range," said Marc Humbert, who was not involved in the research, from the Universite Paris-Saclay, France."This is something we can measure fairly easily, meaning that lung function could be used as part of a screening tool," he suggested.--IANSrvt/dpb
An Ayurvedic poly-herbal formulation, NEERI-KFT, has the potential to not only slow down the progression of chronic kidney disease but also restore normalcy in functional parameters of the vital organ, a team of researchers has claimed.
In a review published in the latest edition of Saudi Journal of Biological Sciences, they said "phytopharmacological evaluation of NEERI-KFT suggests that it exhibits substantial potential against oxidative and inflammatory stress induced apoptosis by exerting antioxidant, nephroprotective and immunomodulatory effects...in the patients associated with renal dysfunction or chronic kidney disease (CKD)".
The NEERI-KFT, a herbal medicine extracted from plants, has been found to correct oxidative as well as inflammatory stress known for reducing body's immunity, said the authors after drawing data on the formulation for kidney ailments from more than five electronic databases such as Science Direct, Google Scholar, Elsevier, PubMed, Springer, ACS publication from published database between 2000 and 2020.
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The study, 'A systematic review on nephroprotective AYUSH drugs as constituents of NEERI-KFT' not only examined the impact of the herbal extract of NEERI-KFT prepared by the AIMIL Pharma interventions on patients, but also dwelled in detail the adverse events of the modern medicine used for the management of the kidney ailments.
The study also highlighted the herbal drug's efficacy in reducing "serum creatinine, blood urea, and serum uric acid as compared to placebo group" and described "its well-tolerated effect with no adverse hematological or biochemical abnormalities occurred to any subjects during clinical trial".
"It can be suggested that NEERI-KFT can be an alternative and complementary therapy at end-stage renal disease (ESRD) or complete loss of kidney function where frequent dialysis of renal transplant remains only a single option for continued survival CKD patients," researchers said.
K.K. Sharma, AIMIL Pharma Managing Director, attributed this to the "more than 20 different potent herbs like haridra, varuna, shirish, gokhru, punarnava and anantamul to name a few in the formulation which are known for their nephro corrective, anti-inflammatory and antioxidant properties and reparative regeneration of kidney cells.
Also, Read This► किडनी के लिए संजीवनी बनी आयुर्वेदिक दवा नीरी केएफटी : अध्ययन
It was after a string of stringent tests that this formulation has been developed to provide relief to kidney patients, he said.
K.N. Dwivedi from Banaras Hindu University said the herbal ingredients in NEERI-KFT are loaded with many anti-oxidants besides medicinal values which not only strengthen kidney but liver also.
"This is a very unique drug and we have found it very effective in our study also," he added.
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Washington, Aug 11 (IANS) The US National Institutes of Health (NIH) has launched a pilot study to assess the antibody response to a third dose of a Covid-19 mRNA vaccine in kidney transplant recipients who did not respond to a two-dose shot of Moderna or Pfizer-BioNTech.The pilot study, called Covid Protection After Transplant (CPAT), will be conducted at Johns Hopkins University in Baltimore, US. The team will enrol up to 200 adults aged 18 years or older who received a kidney transplant a year or more prior to enrolment and have had no recent organ rejection or change in immunosuppression, the NIH said in a statement. The lifelong immunosuppressive therapy that organ transplant recipients must take to prevent organ rejection blunts their immune response to both pathogens and vaccines. Research has shown that many organ transplant recipients do not develop antibodies against SARS-CoV-2, the virus that causes Covid-19, after receiving Covid-19 vaccines. The study aims to determine whether a third dose of one of the mRNA Covid-19 vaccines could overcome this problem for at least some kidney transplant recipients. This is particularly important because this population has a high prevalence of conditions that are risk factors for severe Covid-19, such as cardiovascular disease and diabetes.The pilot study also aims to identify characteristics that could help distinguish those kidney transplant recipients who would benefit from a third dose of an mRNA vaccine from those who will require a different approach to achieve protection. The third-dose vaccine intervention was chosen because of the demonstrated safety of the two-dose mRNA vaccine regimen in solid organ transplant recipients as well as the efficacy of additional doses of other vaccines, such as those for hepatitis and influenza, in immunocompromised people, the NIH said.The study participants will be followed for one year after enrolment. Preliminary results are expected in September 2021.--IANSrvt/bg
Noida, Aug 5 (IANS) A 80-year-old mother has donated her kidney to save the life of her son, displaying the epitome of love and sacrifice. The case has entered the India Book of Records for the 'aged living female kidney donor'.Madeleine, a farmer from Cameroon (Gulf of Guinea, Central Africa), donated a kidney to her son Joseph, 52, who was suffering from a prolonged kidney disease resulting in kidney failure. A team of doctors at Jaypee Hospital successfully conducted the highly complicated kidney transplant surgery, the hospital said in a statement on Thursday."Madeleine's old age was of a major concern for us as mostly the health of the kidney starts deteriorating after the age of 65. After proper evaluation, it was found that she had good kidney functions and was found medically fit to donate her kidney," said Amit K Devra, Director, Coordinator Kidney Transplant Programme, Department of Urology and Kidney Transplant at Jaypee, which has successfully completed more than 650 kidney transplants. "However, she had a complex kidney anatomy with two renal arteries and two ureters for which we had to connect two tubes instead of one for the proper renal functioning," said Amit K Devra, Director, Coordinator Kidney Transplant Programme, Department of Urology and Kidney Transplant at Jaypee, in a statement. "Generally, normal people have one renal artery and ureters. A small stone was also diagnosed in her kidney. This made the process even more complicated, but without any hesitation, we took up the challenge in order to save our patient's life," he added. Madeleine's kidney harvesting was done laparoscopically to reduce the post-operative pain. After kidney removal, the stone was removed (ex vivo) while the kidney was in an ice bucket for perfusion. Both renal arteries were then connected separately with the recipient's blood vessels, the doctor said."It takes an incredible amount of strength, endurance and faith to donate a kidney at this age. She did not lose hope and her strong will to save her son's life pushed her to not give up at any point. The donor was discharged on the fifth post-operative day, whereas the recipient was discharged on the eighth post-operative day," said Dr Vijay K Sinha, Associate Director, Department of Nephrology and Kidney Transplant at the hospital.The team of doctors who successfully conducted the complicated kidney transplant surgery had Dr Devra, Dr Sinha, Dr LP Chowdhury, Dr Ravi Singh, Dr Anuj Arora, Dr Khushboo Singh and other paramedical staff.--IANSrvt/na