There is a small, but growing, subset of livers that have been transplanted and have a cumulative age of more than 100 years, researchers said.
The researchers said they studied these livers to identify characteristics to determine why these organs are so resilient, paving the way for considering the potential expanded use of older liver donors.
"Livers are incredibly resilient organs," said lead study author Yash Kadakia from the University of Texas (UT) Southwestern Medical Center, Dallas.
"We are using older donors, we have better surgical techniques, we have advances in immunosuppression, and we have better matching of donor and recipient factors. All these things allow us to have better outcomes," Kadakia added.
For the study, presented their findings at the Scientific Forum of the American College of Surgeons (ACS) Clinical Congress 2022, the team used the United Network for Organ Sharing (UNOS) STARfile to identify livers that had a cumulative age (total initial age at transplant plus post-transplant survival) of at least 100 years.
Of 253,406 livers transplanted between 1990-2022, 25 livers met the criteria of being centurion livers those with a cumulative age over 100 years.
"We looked at pre-transplant survival essentially, the donor's age as well as how long the liver went on to survive in the recipient," said Kadakia.
"We stratified out these remarkable livers with over 100-year survival and identified donor factors, recipient factors, and transplant factors involved in creating this unique combination where the liver was able to live to 100 years," Kadakia added.
For these centurion livers, the average donor age was significantly higher, 84.7 years, compared with 38.5 years for non-centurion liver transplants.
The researchers noted that for a liver to make it to 100, they expected to find an older average donor age and healthier donors. Notably, the donors from the centurion group had a lower incidence of diabetes and fewer donor infections.
Read More► Ultrasound Can Move, Break Up Kidney Stones in Awake Patients: Study
The number of people diagnosed with or dying from primary liver cancer per year could rise by more than 55 per cent by 2040, reveals a new analysis.
According to a new report, published in the Journal of Hepatology, countries must achieve at least a 3 per cent annual decrease in liver cancer incidence and mortality rates to avoid this increase.
"Liver cancer causes a huge burden of disease globally each year," said researcher Isabelle Soerjomataram, International Agency for Research on Cancer (IARC/WHO), Cancer Surveillance Branch, Lyon, France.
"It is also largely preventable if control efforts are prioritised major risk factors include hepatitis B virus, hepatitis C virus, alcohol consumption, excess body weight, and metabolic conditions including type 2 diabetes," Soerjomataram added.
For the research, the team extracted data on primary liver cancer cases and deaths from the International Agency for Research on Cancer's GLOBOCAN 2020 database, which produces cancer incidence and mortality estimates for 36 cancer types in 185 countries worldwide.
The predicted change in the number of cancer cases or deaths by the year 2040 was estimated using population projections produced by the UN.
Results showed that in 2020, an estimated 905,700 individuals were diagnosed with liver cancer and 830,200 died from liver cancer globally.
According to these data, liver cancer is now among the top three causes of cancer death in 46 countries and is among the top five causes of cancer death in nearly 100 countries, including several high-income countries.
Liver cancer incidence and mortality rates were highest in Eastern Asia, Northern Africa, and South-Eastern Asia. Investigators predict the annual number of new cases and deaths from liver cancer will rise by more than 55 per cent over the next 20 years, assuming current rates do not change.
Read More► Simple Swaps to Keep Your Heart Healthy
Among the many benefits of maintaining heart health include the ability to live a long life, relieve symptoms of depression, and reduce the chance of dementia. According to a proverb, "With a healthy heart, the beat carries on." The path to a healthy heart is broken down by Luke Coutinho, Holistic Nutrition and Lifestyle - Integrative and Lifestyle Medicine, Founder of You Care.
Tips to Keep Your Heart Healthy
Emotional Health: Today emotional health is a no.1 priority for better heart health. Negative emotions and thoughts stimulate the flight and fight response which results in the production of cortisol. Elevated levels of cortisol are known to also elevate blood pressure, heart rate, and inflammation, all of which can harm heart health. Invest more time in healing yourself emotionally through yoga, pranayama, meditation, visualization, laughter, positive affirmations, etc.
Vitamin Breathing: One deep inhale and exhale is all it takes to calm your mind and heart. Deep breathing is known to shift our body from a state of fight and flight to a state of rest and digestion almost instantly. This makes a regular practice of deep breathing an extremely heart-healthy habit.
Anti-Inflammatory and Antioxidant-Rich Foods: The main reasons behind heart attacks are not cholesterol but inflammation and oxidative damage in the heart, blood vessels, endothelial lining, arteries, etc. Inflammation and oxidative damage are caused by the free radicals from the food that we eat, the air that we breathe, and several lifestyle choices that we make. Foods like turmeric, ginger, garlic, and black pepper - are potent foods to curb inflammation. Additionally, eat an array of differently colored fruits and berries when they are in season.
Prioritize Sleep: Poor sleep or lack of sleep can be destructive to our heart health. This is because when we sleep, the heart gets a break and works lesser. The heart is a muscle and it requires recovery. Lack of sleep also increases insulin resistance, blood pressure, and inflammation.
Stay Active: Sitting excessively is like smoking. Make sure you are physically active throughout the day. The risks of heart attacks are more in people who live inactive lifestyles. Walking, yoga, Zumba, and trekking are extremely beneficial exercises for the heart.
Cut Out Smoking: Both active and passive smoking is toxic to the heart. Smoking contributes to both oxidative damage and inflammation in the body. The chemicals emitted from cigarette cause plaque build-up in the arteries. It also depletes several vitamins and minerals and hardens the arteries.
Get more raw food in your diet for its fiber and antioxidant intake.
10 foods that will help your heart stay young and healthy
Good Quality Oils: like coconut oil, pure A2 Gir cow ghee, and mustard oil help boost good cholesterol and fight inflammation.
Omega 3-Rich Foods: Omega 3 fatty acid is an important and extremely healthy fatty acid for the heart. It helps in curbing inflammation, heals arterial walls, and boosts HDL while lowering LDL. E.g.: fatty fish, flax seeds, walnuts, and chia seeds to name a few.
Beetroot: for its ability to act as a vasodilator and high antioxidant content.
Garlic: for its inflammatory and bad cholesterol-lowering properties. It also acts as a natural blood thinner.
Organic Tea (black, white, oolong, matcha): for its high antioxidant content, especially EGCG. Also, research now finds that it holds potent cholesterol-lowering properties and can prevent plaque build-up in the arteries.
Fruits Like Grapes, Pomegranate, and Berries: for their high antioxidant content.
Vitamin E-Rich Foods: for their ability to curb inflammation, fight free radicals, cell repair, and heal arteries. It's a must-have for people who are exposed to cigarette and industrial pollution. E.g.: sunflower seeds, unsalted peanuts, avocados, almonds, and sesame.
Magnesium-Rich Foods: for their ability to boost cardiac muscle health, and blood pressure. E.g.: all nuts and seeds, green leafy vegetables, cacao.
Potassium-Rich Foods: plays a role in every heartbeat. It manages blood pressure, and cardiac muscle contractions and keeps the heart rhythm steady. E.g.: banana, avocados, pumpkin.
Vitamin K-Rich Foods: for high antioxidant properties and preventing calcification of arteries. E.g.: green leafy vegetables, broccoli, prunes, avocado.
Foods to Avoid
Refined Sugar and Refined Carbohydrate Intake: Both of them can contribute to inflammation, spike blood sugar levels and thus increase the risk of a heart attack. Also, excess of both could lead to elevated triglyceride levels. On the other hand, complex carbs like dosas, idlis, rotis, hand-pounded rice, etc are all healthy carbs and can be included in your diet for good health and preventing the risk of a heart attack. People who give up on such complex carbs end up being deficient in Vitamin K2 - which can result in the calcification of arteries.
Refined Salt: Refined salt and MSG can create inflammation in the body, elevate blood pressure and cause water retention thereby burdening the kidneys. One can opt for Himalayan pink or rock salt after they keep their health professional in the loop.
Refined Oils: Refined vegetable oils are rich in omega-6 fatty acids. Omega 6 is harmful to health as it leads to inflammation and oxidative stress in the body.
Processed and Packaged Foods: Processed and packaged foods too are causative to increased rates of heart attacks and stroke. This is again because this packaged and processed food is prepared with low-grade refined oil which increases oxidative damage and inflammation in the body.
Excessive Tea and Coffee, Alcohol: Overconsumption of tea, and coffee can aggravate or cause acidity and inflammation, more so if the beverage contains sugar, cream, and other additives. Alcohol too can raise bad cholesterol, cause inflammation and elevate blood pressure.
Read More► Walnuts For A Healthy Heart
In 2016, according to the WHO, India reported 63 per cent of total deaths due to non-communicable diseases, and 27 per cent were attributed to cardiovascular disease (CVD). Of those, heart attack and stroke are two of the most common causes of death in our country. Now those are pretty scary numbers, and they are only growing by the year.
Blame it on our family's medical history or the fast-paced lifestyle that's leading to complaints of high cholesterol, but you and I, too, are at the risk of developing heart disease. Fortunately, several factors help us lower our risk of CVD and take the high road to a healthy heart. In anticipation of World Heart Day, let's deep dive into how you can lower the risks with Ryan Fernando, Celebrity Nutritionist and Founder of QUA Nutrition -- Signature Nutrition Clinic
Q. How do walnuts help your heart health?
Ans. According to research, an important move is to consume a handful of California walnuts as part of a healthy, nutritious diet and couple it with physical activity. This may help lower your risk of heart disease and hence, deserves a spot on your plate. The polyunsaturated fats, aka good fats, and ALA (alpha-linolenic acid) in these wonder nuts may improve cholesterol levels and lower blood pressure, which are two major contributors to heart disease risk.
1,2. In addition, these nutrient powerhouses are known to help reduce inflammation and improve blood vessel function.
3. A recent scientific review published in Advances of Nutrition also suggests that food sources high in plant-based omega-3 ALA, such as walnuts, should be part of a heart-healthy eating pattern.
4. Not convinced yet? The American Heart Association (AHA) has found that including four or more servings of nuts, including walnuts every week and other foods, may help lower one's risk of heart disease. And that's not it, AHA has also certified walnuts as a heart-healthy food through its 'Heart Check Mark' programme.
Q. What is the ideal portion of walnuts one should consume?
Ans. A handful of walnuts, which is nearly 28 g, is advisable for daily consumption. This amount contains 2.5g of essential plant-based omega-3, 4g protein, and 2g fibre, all essential for overall wellness.
Q. What is the best time of the day to eat walnuts?
Ans. While walnuts can be eaten throughout the year, at any time of the day, I believe the best time to eat them is in the evenings. These contain PICO melatonin, which goes into your brain and increases serotonin levels, eventually promoting sleep.
Q. Five simple ways to include walnuts in your daily diet
Make snack time healthy with a handful of plain California walnuts, or you can amp up the flavour by sprinkling your favourite spice mix over them
Mix coarsely grounded walnuts with a portion of hung curd and turn it into a delicious creamy dip
You can also grind walnuts and add them to your curries, which are a good source of plant-based omega-3
Poha, upma, or kachumbar, walnuts add a perfect crunch for any time snacks
Walnuts are the perfect accompaniment for a low-calorie diet, and another great idea to consume is by blending them into your morning smoothie
We all deserve to choose what's best for us. And for making such decisions, you need the right information. Now that you've read about the health benefits of walnuts, it's time to go nuts about these nuts! (N. Lothungbeni Humtsoe )
Read More► Fasting With Diabetes?
Each woman is affected by menopause in a unique way. Numerous symptoms, including irregular periods, hot flashes, sweating, sleep difficulties, mood swings, irritability, hip and back pain, and more, are associated with this transition for many women.
"Indian women typically go through menopause early, at the average age of 46.2 years, five years earlier than in western nations. Hormonal changes begin even earlier during perimenopause or the time around menopause, which lasts four years or even up to a decade.
During this period, 80 per cent of women are affected by menopausal symptoms. A holistic approach to managing this phase can help women relieve the discomfort and stay healthy," said Jaideep Malhotra, former President of the Indian Menopause Society and South Asian Federation of Menopause Societies.
The secret to a healthier life is to prepare for this time, just as we do for other life milestones like job interviews and parenthood. Here are four general actions you can take to manage menopause better:
Maintain A Balanced Diet
Good nutrition is a game changer for managing menopause symptoms from hot flashes to bloating. Foods to include and to avoid in your diet are:
Fruits And Vegetables: These are full of the vitamins, minerals and antioxidants your body needs. You cannot go wrong with seasonal vegetables and fresh fruits.
Fibre: Rich foods and foods rich in calcium and vitamin D: High-fibre foods like leafy greens, kidney beans and wholegrains can also support better health. Dairy products and foods rich in omega-3 fatty acids are good sources of nutrition.
Fatty Meats & Processed Foods: Fast or fried foods, processed snacks and meat are high in sodium, making you feel bloated. These foods can also affect cholesterol levels or increase your risk of heart disease. Also, spicy food may trigger symptoms like hot flashes.
Alcohol: Moderation is key. Regular alcohol consumption can lead to amplified menopausal symptoms, problems sleeping and heightened mental health issues.
Caffeine: A caffeine kick makes you more likely to have hot flashes. Resorting to alternative warm drinks is suggested.
Stay Active: Regular exercise can keep your bones strong, improve your mood and combat symptoms like weight gain as your body changes. You can attempt the following activities:
Cardio: Aerobic activities or cardio include endurance activities that encourage you to use your large muscles. You can start with 10-minute a day of brisk walking, jogging, swimming, running, cycling, or even dancing, and build up the intensity as you go
Strength Training: Lifting dumbbells or using weight machines can help strengthen your muscles and bones, while also reducing body fat
Yoga: Yoga poses from restorative and supportive to power yoga are also a good source of targeted symptom relief, helping relax the body. Paired with meditation or breathing exercises, these can also prompt relaxation and mindfulness.
Emotional and mental health may be impacted by hormonal changes during peri menopause or menopause. Women going through this stage may exhibit symptoms, including insomnia, anxiety, immobility, exhaustion, stress or depression. The majority of the symptoms can be controlled by altering one's lifestyle. These symptoms may be lessened by exercise, healthy eating habits, drinking plenty of water, and relaxation techniques for restful sleep. Find what works for you and make realistic, attainable goals.
Consult With A Doctor
Co-morbid disorders, such osteoporosis and heart disease, which menopausal women are more likely to develop, can be prevented by maintaining good health. Additionally, there are a variety of therapeutic choices for menopause symptoms, such as menopausal hormonal therapy, which can help keep your body's oestrogen levels stable and control symptoms. If you experience symptoms that concern you, it is always advisable to see a doctor.
"Menopause is a time of transition for women, which can prove challenging. At Abbott, believe it is vital to raise awareness on the physical, mental and overall emotional aspects of menopause, so that women can seek the help they may need and live this life stage fully.
At the same time, we partner with healthcare professionals to share therapy best practices and change how we address women experiencing menopause, to support women holistically, beyond physical symptoms," said Jejoe Karankumar, Medical Director, Abbott India. (Jaideep Malhotra, former President of the Indian Menopause Society and Jejoe Karankumar, Medical Director, Abbott India)
Read More► The Dos & Don'ts of Using Lemon on Your Skin
Chandanasav is an Ayurvedic fermented liquid preparation made up of 24 botanicals, with "chandana", i.e. sandalwood, as the main ingredient. Contains 5-10% self-produced alcohol, which helps in the extraction of alcohol-soluble ingredients and helps preserve the active ingredients for a longer period of time.
Normally one sweetener is used in each asava, but in Chandanasav two sweeteners are used in a 2:1 ratio (2 parts rock candy to 1 part brown sugar). This combination, in addition to Chandana, enhances the cooling effects of Chandanasav.
Chandanasav has SEETA VIRYA (cold potency) which makes it the best medicine for Pitta disorders.
It is widely used in various urinary and urogenital diseases. It acts as a urinary antiseptic and an excellent remedy for skin diseases. Chandanasav is also used for male and female reproductive disorders such as menorrhagia (excessive or prolonged menstrual bleeding), postmenopausal syndrome, and leukorrhea in women and spermatorrhea in men.
It also helps cleanse septic ulcers in the urinary tract that developed in the early stages of syphilis. Chandanasav is an excellent cardiac tonic with its cardioprotective effects.
Chandanasav is 100% Ayurvedic and safe and is available in liquid form in the market. The dose of Chandanasav depends on the age, sex, weight and condition of the patient. So let us start with this article which will give you complete information about Dhootapapeshwar Chandanasav.
Dhootapapeshwar Chandanasav Shloka
चन्दनं बालकं मुस्तं गम्भारीं नीलमुत्पलम्।
प्रियङ्गुं पद्मकं लोध्रं मञ्जिष्टां रक्तचन्दनम्।।
पाठां किरतातिक्तांच न्यग्रोधं पिप्पलीं शठीम्।
पर्पटं मधुकं रास्नां पटोलं कांचनारकम्।।
आम्रत्वचं मोचरसं प्रत्येकं पलमात्रकम्।
धातकीं षोडशपलां द्राक्षायाः पलविंशतीम्।।
जलद्रोणद्वये क्षिप्त्वा शर्करायास्तुलां तथा।
गुडस्यार्ध्दतुलंचापि मांसं भाण्डे निधापयेत्।।
चन्दनासवं इत्येष शुक्रमेहविनाशनः।
बलपुष्टिकरो हृद्यो वह्निसंदीपनः परः।।
[भैषज्यरत्नावली शुक्रमेहाधिकर (३४-३८)]
Herbs/components Used in Chandanasav
Chandanasav is an ayurvedic medicine that is composed of herbs and those are:
Traditionally, Chandanasav is used to treat spermatorrhea and burning urination. It is also used to improve strength and immunity. It is a natural cardiac tonic. It also improves digestive power. Chandanasav for spermatorrhea and burning urination. Spermatorrhea is a sexual disorder characterized by excessive and involuntary ejaculation. It has a devastating effect on men. So Chandanasav offers a better cure for that pesky male hysteria. It is also an excellent drug to treat burning sensation when urinating.
Chandanasav for Urinary Tract Infections
Endowed with antimicrobial and bacteriostatic properties, Chandanasav is an excellent remedy for urinary tract infections. It also helps reduce pus cells in the urine and prevents them from coming back. In addition, it also relieves the bad smell of urine and the burning sensation in the hands and feet.
Chandanasav As A Heart Tonic
Rich in antioxidants, Chandanasav strengthens the heart muscles, improves heart rate and promotes the healing process of cardiovascular diseases.
Chandanasav to Strengthen Strength And Immunity
Chandanasav helps increase the number of white blood cells in the blood and keeps infections away.
Chandanasav for Indigestion
Musta (Cyperus rotundus) in Chandanasav controls acid secretion in the stomach and helps reduce bloating. Prevents gastroesophageal reflux disease, constipation and diarrhea.
Chandanasav for Reproductive Disorders
Chandanasav is beneficial for male and female reproductive disorders. In men, it helps reduce nighttime sleepiness, spermatorrhea, promotes fertility and increases libido. In women, it is effective in reducing menorrhagia (excessive or prolonged menstrual bleeding), leukorrhea (excessively thick, white or yellowish vaginal discharge). The red and white sandalwood in Chandanasav has cooling properties that help combat the side effects of postmenopausal syndrome, such as hot flashes, night sweats, and burning. It is also helpful in reducing the burning sensation associated with fever.
Chandanasav for Kidney Stones
Chandanasav is used to treat uric acid kidney stones as it balances the pitta dosha in the body. Its diuretic and lithotritic action helps reduce uric acid levels in the body and helps dissolve kidney or bladder stones and also prevents their recurrence.
Chandanasav for Skin Diseases
Chandanasav can be used as an effective medicine for various skin conditions like eczema, hives, scabies, and fungal infections.
Chandanasav Side Effects
Chandanasav consists of natural ingredients and therefore has no known side effects. However, people with diabetes are advised to monitor their glucose levels while consuming Chandanasav as it contains rock candy and brown sugar. Pregnant and nursing mothers should avoid taking Chandanasav unless directed by a doctor.
Take 1-2 tablespoons of Chandanasav with the same amount of water twice daily after meals or as directed by a healthcare professional.
Chandanasav Storage and Safety Information
Please read the label carefully before consumption.
Stay away from children.
Store in a cool, dry place away from sunlight.
The drug should be stored at room temperature.
Frequently Asked Questions (FAQ's)
Q. Should I abstain from allopathic medicine while taking Chandanasava?
Ans. Ayurvedic medicines do not react with other medicines. Consult your doctor for more specifications.
Q. Is Chadanasav available without a prescription?
Ans. Yes, Chandanasav is an Ayurvedic medicine that can be purchased without a prescription.
Q. What is the source of this Chandanasav?
Ans.Chandanasav is a herbal supplement.
Q. Is chandanasava used to gain weight or increase appetite?
Ans. Chandanasava is used to increase appetite.
Q. Does daily consumption of Chandanasav harm the body?
Ans. No, Chandanasav is a completely natural and safe medicine with no harmful effects on your body. However, take it as directed by your doctor.
Q. Do I need to avoid certain foods while taking Chandanasav?
Ans. No, Chandanasav does not react with food. However, get your doctor's advice for best effect.
Q. Does Chandanasava induce sedation?
Ans. No, Chandanasava does not cause sedation.
Q. Is the alcohol content in Chandanasav harmful to children?
Ans. No, Chandanasav contains homegrown alcohol which is purely natural and will not cause any problems for children.
Q. Can I take Chandanasava with alcohol?
Ans. No, do not consume Chandanasava with alcohol as it may cause drowsiness.
Q. Does Chandanasav cause addiction?
Ans. No Chandanasav is not addictive.
Q. Can I consume Chandanasav during pregnancy?
Ans. It is better to avoid Chandanasav during pregnancy unless directed by a physician.
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