Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, finds a new research.
The study, completed in an animal model, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function.
MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue).
"This research promotes the concept that MDSC expansion during obesity to become osteoclasts during periodontitis is tied to increased alveolar bone destruction," said researcher K.H. Kwack from the University at Buffalo.
"Taken together, this data supports the view that obesity raises the risk of periodontal bone loss," Kwack added.
Bone loss is a major symptom of gum disease and may ultimately lead to tooth loss.
Also known as periodontal disease, gum disease affects more than 47 per cent of adults 30 years and older, according to the Centers for Disease Control and Prevention.
For the study, published in the Journal of Dental Research, the team examined two groups of mice fed vastly different diets over 16 weeks -- one group, a low-fat diet that derived 10 per cent of energy from fat, the other group a high-fat diet that drew 45 per cent of energy from fat.
The investigation found that the high-fat diet group experienced obesity, more inflammation and a greater increase of MDSCs in the bone marrow and spleen compared to the low-fat diet group.
The high-fat diet group also developed a significantly larger number of osteoclasts and lost more alveolar bone (the bone that holds teeth in place).
Also, the expression of 27 genes tied to osteoclast formation were significantly elevated in the group fed a high-fat diet.
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The World Health Organization (WHO) has associated approximately 4.2 million premature deaths per year with health issues related to air pollution. According to the Global Burden of Disease (GBD) outdoor air pollution is related to more deaths than unsafe sex leading to HIV/AIDs, unsafe water, or malaria. Annual air pollution-related diseases also have a much higher death toll than Covid-19 to date.
With the country's air quality plummeting to hazardous levels after Diwali, people are complaining of respiratory trouble such as shortness of breath, wheezing, and incessant coughing. The high pollution levels are also likely to impact more people this year as a significant proportion of people who recovered from Covid-19 might not have completely healthy lungs. People are opting for various measures to combat the ill effects of pollution. Listed below are some important products that you can get your hands on to fight pollution.
1. Phillips Air Purifier: This purifier is the one product that everyone should own. It comes with 4 stage filtration and automatically senses the air quality and removes 99.97 per cent of airborne pollutants. It can purify a standard room within 12 minutes and provide real-time air quality feedback.
2. GO2 Therapy, Portable Oxygen Cans: gO2therapy was launched in April 2021. It is the second generation of high-purity (99 per cent+) portable Oxygen can, which is highly useful in our day-to-day life situations like pollution and emergencies. gO2 therapy can be used to perform oxygen therapy at home to help the body fight the ill effects of the city's pollution and not only increase mental and physical performance among fitness enthusiasts but also help in dealing with respiratory issues.
3. SmileDrive Portable Air Quality Meter: This portable meter is a great way to detect air quality indoor and outdoor. It detects the air around through air scattering detection. The big monitor screen can be used easily at the home, office or outdoors in the car. It has an inbuilt rechargeable battery and runs 10 times faster to provide accurate readings.
4. Boldfit N95 Reusable Masks: The N95 face mask, as suggested by doctors provides personal protection against dust, allergens, fog haze and is anti-odour. It is made of activated carbon that has cotton to ensure that the skin remains fresh all day. It also provides protection against dust and could be worn outdoors and indoors.
5. Environics Envirochip: Envirochip is clinically tested and certified with proven health benefits. It protects you from the harmful effects of electromagnetic radiation. It helps to reduce stress and boosts protects your immunity so that you can use your tech gadgets safely.
The small chip comes with one-of-a-kind technology that helps nullify the harmful effect of e-radiation emitted by a laptop/ mobile phone/ Smart TV/ Monitor, etc without compromising device performance. You can easily stick the chip at the body of your laptop or mobile phone the chip built on the foundation of radiation protection technology, changes the nature of electromagnetic radiation, making it harmless to the human body. (Agency)
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In todays day and age with the kind of food available, nutrition is generally lacking in the growing kids. To build a strong immune system, children need the right and enough nutrients. Below are a few Superfoods which can help kids boost their immunity and help in their growth.
1. OZiva kids Superfood immunity Multi Gummies- OZiva Superfood Immunity Multi is a clean blend of powerful superfoods with Ayurvedic Herbs specially created to support enhanced immunity in children. It boosts and strengthens the immune system with plant-based Vitamin C, supports the production of white blood cells and antibodies to fight infections, reduces chances of infection with Zinc's anti-inflammatory properties,
helps keep the immune system balanced with Vitamin D by preventing it from overreacting, combats illnesses, increases immune cells and maintains healthy immune system with plant-based extracts of Elderberry, Amla and Acerola Cherry. These delicious gummies are easy to chew and are vegan with no preservatives, gelatin free, no artificial sweeteners, no artificial colour, soy-free. Recommended 1 gummy daily for children of age 5 years and above.
2. Fast&Up Charge Kids- Fast&Up provides high-quality supplements and vitamins to increase performance. Fast&Up Charge Kids has a triple action formula with Immunity Booster Herbs like Curcumin, Ginger and Tulsi which helps strengthen the body's defence system. It has essential nutrients, Active Vitamin C Complex, Natural Amla, 100% RDA Vitamin C which helps to boost immunity. Kids above the age group of 4+ can consume Fast&Up Charge Kidz.
3. NutriBears Daily Multivitamin Gummies- This advanced NutriBears Kid's Multivitamin Gummy supplement helps in filling the gaps in your child's diet. Fortified with a vitamin complex that contains Vitamins A, B5, B12, C, D, and E, as well as Folic Acid, Iodine, Magnesium and Zinc, our vitamin gummies taste great and give your child the boost they need to be at their physical and mental best.
4. Patanjali Nutrela Kid's SuperFood Nutrition Drink- Patanjali Nutrela Kid's Superfood is a scientifically designed advanced formula as per ICMR guidelines for every growing kid for 4-12 years in delicious chocolate flavour. An ideal blend of milk protein and vitamins with botanical extracts. It is 100 per cent vegetarian, GMO-free, gluten-free, no artificial colour, preservative-free and trans-fat-free. Balanced nutrition for active growth with essential amino acids.
5. Amazing Grass Kidz Superfood - Berry Blast- This nutritional smoothie combines the farm fresh greens with a rainbow of over 30 wholesome fruits and veggies providing kids with the whole food nutrition their growing bodies need and the amazing taste they'll love. This plant-based drink is dairy-free, Certified Organic by CCOF - Non-GMO and More. (Agency)
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Indians eat more fibre-rich plant based diet than people in the Western countries, reducing their risk of gut-related problems such as inflammatory bowel diseases like crohn's disease, Irritable Bowel Syndrome (IBS), colitis, and colon cancer, according to a research on Tuesday.
The international study, including researchers from the Indian Institute of Science Education and Research (IISER)- Bhopal, sought to understand the relationship between gut bacteria and inflammatory diseases.
"Increased intake of carbohydrate in the form of fibre such as wheat, vegetables, fruits and lentils, mostly found in Indian diet lowers the incidence of IBD, crohn's disease, colitis, colectral cancer, etc., than western diets that are generally meat-based," lead author Dr Vineet K. Sharma, Associate Professor, Department of Biological Sciences, IISER Bhopal, told IANS.
The human gut contains 300-500 types of bacteria that are necessary for our survival. These bacteria help in digestion, protect us from infections and even produce essential vitamins and neurochemicals.
Depending on the kind of bacteria that dominates the gut, human beings are generally classified into three "enterotypes" -- Prevotella, Bacteroides or Ruminococcus.
The study included 586 healthy samples from western and non-western populations including 200 samples from India, and 189 IBS samples from western populations.
The 200 gut samples from India were taken from people from several locations in -- Madhya Pradesh, Delhi-NCR, Rajasthan and Maharashtra, Bihar, and Kerala. It is also the largest gut metagenome study from India, as most such studies are largely based on the Western population.
The findings, published in the Nature's Biofilms and Microbiomes journal, showed that the Indian gut microbiome has the highest abundance of the Prevotella genus of bacteria, in particular, a species called Prevotella copri (P.copri).
This bacterium was also found to dominate the guts of other populations that consume a carbohydrate and fibre-rich diet, such as the Italian, Madagascarian, Peruvian, and Tanzanian. But, the gut microbiomes of people from Western countries like the US are dominated by Bacteroides.
Further, they found that P. copri is significant in the metabolism of complex polysaccharides and dietary fibres in non-western populations.
It is thus logical that this type of bacteria predominates the gut microbiome of the healthy Indian and non-western population that consumes a diet rich in plant-carbohydrates and fibres, Sharma explained.
"The proportion of P.copri in Indians is 30 per cent and can reach upto 60-70 per cent. Of the more than 1200 species of Prevotella, P.copri is the most abundant in Indian human gut," Sharma told IANS.
On the other hand, the guts of Western population were found to have other Prevotella species such as P. intermedia and P. nigrescens. These bacteria are usually found in the mouth, which points to a mouth-gut axis. These bacterial species are inflammatory and have high virulence and antibiotic resistance genes, making the Western population more susceptible to gut inflammatory diseases.
"Our insights would help in the development of new probiotics and prebiotics for different health-related conditions associated with the gut which is much needed for non-western populations," Sharma said.
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A team of Israeli researchers have identified five proteins in the SARS-CoV-2 virus that are responsible for severe vascular damage that could lead to heart attack or stroke.
While Covid-19 is largely known as respiratory disease, there has been a very high incidence of vascular disease and blood clotting, for example stroke and heart attack, among Covid patients.
Researchers from Tel Aviv University identified the five proteins from a total of 29 different proteins that make up the novel coronavirus. When the coronavirus enters the body, it begins to produce 29 proteins, the team said.
In the process of infection and the protein development, the "blood vessels turn from opaque tubes into kind of permeable nets or pieces of cloth, and in parallel there is an increase in blood clotting", said Dr Ben Maoz, Afrom the varsity's Department of Biomedical Engineering and Sagol School of Neuroscience.
The team thoroughly examined the effect of each of the 29 proteins expressed by the virus, and were successful in identifying the five specific proteins that cause the greatest damage to endothelial cells and hence to vascular stability and function.
"We tend to think of Covid as primarily a respiratory disease, but the truth is that coronavirus patients are up to three times more likely to have a stroke or heart attack. All the evidence shows that the virus severely damages the blood vessels or the endothelial cells that line the blood vessels. However, to this day the virus has been treated as one entity. We wanted to find out which proteins in the virus are responsible for this type of damage," Maoz said.
In the study, published in the journal eLife, the team used the RNA of each of the Covid-19 proteins and examined the reaction that occurred when the various RNA sequences were inserted into human blood vessel cells in the lab.
In addition, the team used a computational model which allowed them to assess and identify which coronavirus proteins have the greatest effect on other tissues, without having seen them 'in action' in the lab.
"Our research could help find targets for a drug that will be used to stop the virus's activity, or at least minimise damage to blood vessels," Maoz noted. (Agency)
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After a sombre year, people all over the world are finally ushering in the festive season with more joy and hope. For many, it will also be the first time they see their extended families and loved ones in over a year. Family gatherings obviously come with feasting, food and drink, however, if you are breastfeeding your baby, then there are some foods that you might want to steer clear of.
The key to a good breastfeeding diet is simply to be on a nutritious and healthy meal plan. After the rigorous process of watching what they eat, new mothers can finally relax and eat almost everything they had to give up for nine months. But this must be done in careful moderation because a newborn baby's diet is still entirely dependent on their mother's milk. Hence, it is important to make sure that mothers eat meals that are rich in nutrients, vitamins and minerals such as iron, calcium, potassium, Vitamin A and Vitamin D.
The list of foods to avoid during pregnancy is long, but thankfully breastfeeding moms can eat almost anything as long it is in moderation. The following foods should be consumed in small amounts if a woman is breastfeeding.
All food items with alcohol and caffeine content should be kept to a bare minimum. Alcohol especially is tricky, because even after having waited for 2-3 hours after the consumption of a drink, a baby can be exposed to it through breast milk, and this could potentially harm an infant's development, growth, and sleep patterns. And as for caffeine, while it is much safer than alcohol, it is recommended that nursing mothers limit their intake to about 300 milligrams per day.
Chocolate can be included back in the diet, as long as it is consumed in small quantities. This is because chocolate does contain theobromine, which is a stimulant and there is a small possibility of it leading to a breastfed infant being restless and fussy. Since any nutrient from the food the mother consumes gets transformed into breast milk, care should be taken to consume avoidable food items in very small amounts.
Stress producing foods or high calorific foods should be avoided: Carbonated beverages, Caffeine, packaged fruit juices with excess sugar, Peppermint or gums, salad dressings with high sodium should be completely avoided. Processed foods are quick and easy to prepare especially when you have a baby.
However, these foods contain preservatives and additives that are toxic for the baby which should be avoided. An expecting mother is suggested to get proper rest and keep stress at bay. While postpartum stress affects many new mothers, experts suggest that managing stress and anxiety is crucial to the well-being of both the mother and her infant. Stress may lead to reduced lactation and breastfeeding issues.
Avoid binge-eating during this time, despite the erratic hours that new parents are bound to experience. Carbonated drinks and junk food cravings should be substituted with healthier food options like nuts and fruits.(Rohit Shelatkar, VP at Vitabiotics, Fitness & Nutrition Expert)
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