Migraine is a debilitating neurological disease, ranking consistently among the top 10 leading causes of years lived with disability, worldwide. The main symptom of migraine is an enduring headache, along with symptoms such as severe pain on one side of the head or throbbing pain, sensitivity to light and sound, and nausea. Despite being a very common headache disorder that affects roughly 15 percent of the adult population worldwide, it remains inadequately understood and most neglected.
In Delhi, approximately 25 per cent of the population suffers from migraines, every year.
While migraine is an invisible condition, it can severely impact individuals across personal, professional and social domains, thus affecting the overall quality of life and productivity. Work-from-home, or the 'new normal,' has drastically impacted the lives of people suffering from migraines from an inability to concentrate at work to missed workdays. It has become even more urgent to ensure that individuals have the understanding and tools to effectively manage migraines.
There is a lack of understanding amongst people about the severity of migraines. In a study we recently conducted, about 50 to 60 per cent of migraineurs were undiagnosed, despite recurrent headaches. Because migraine falls on a spectrum, ranging from infrequent or mild attacks to recurrent ones, many pass it off as merely a headache'. With busy work-from-home schedules, paired with fear of contracting COVID-19 infection and difficulty in accessing in-person care, people are avoiding seeking medical help for the condition, instead attributing symptoms to associated comorbidities, such as stress or depression."
He continued, "Financial worries due to job loss or salary cuts also contribute to aggravated migraine attacks, which is more noticeable recently. The effects of migraine on one's quality of life also reportedly worsened, particularly for many migraineurs working as essential healthcare workers at this time.
Symptom neglect and failure to treat the condition can lead to migraines becoming chronic. A fundamental need is to recognize migraine as a serious condition with severe disability and adopt a holistic treatment approach. Early detection can be a key enabler of a smoother patient journey and an improved quality of life."
Here are 5 ways to manage your migraine while working from home:
Identify Risk Factors and Monitor Triggers
Migraines can begin at any age but tend to peak during one's prime productive years. Moreover, women are three times more likely to be affected than men, with prevalence peaking between the ages of 25 and 55 years.
Long hours of working from home, along with longer screen times, disrupted sleep schedules and irregular eating habits can increase stress levels. For migraineurs, such changes can become migraine triggers, exacerbating their condition. Identifying personal triggers can help individuals manage their migraines better.
Make The Right Choice for Diet and Lifestyle
Working from home can be hard, but a daily routine that optimizes your physical and mental health can help keep your migraine at bay. Eating healthy meals at appropriate times or consuming small, frequent meals throughout the day are associated with less frequent migraine headaches. Taking breaks from work at regular intervals can help you eat right and reduce eye strain owing to excessive screen use. Making modifications to your lifestyle, including smoking cessation and reduced alcohol consumption, and maintaining optimal sleeping habits and exercising regularly can be key to manage migraines. These also benefit migraine prevention and treatment.
Talk to An Expert
It is important to consult a medical specialist when you are experiencing severe headaches that disrupt your daily routine. A lot of migraineurs hesitate to seek medical help. This could be due to several reasons lack of understanding of migraine severity, lack of time due to hectic work-from-home schedules, or recently, due to a reduction in-person clinic consultations owing to the fear of Covid-19 infection. However, consulting a neurologist, even via teleconsultations, is a necessary step to diagnose your condition and understand the available options for acute and chronic management of migraine, including preventive treatment. With evidence-based information on effects across migraine intensity reduction, quality of life and ease of use, neurologists can guide you on the most suitable treatment option to prevent or reduce your migraine episodes.
Track Your Migraines
It is a good idea to maintain a diary (or download a migraine tracker app), to record the time and severity of your migraine attacks, symptoms, daily diet, exercise routines, and medications and side effects. This can help identify triggers and patterns. It can also prompt meaningful conversations with your doctor, contributing to a more holistic treatment plan, personalized to suit your work schedule.
Seek Support From Your Family, Friends or Colleagues
Living with migraines can make one feel helpless, distressed and misunderstood. But talking to your friends and family will help them understand your condition better. Having an open conversation about your migraine with your employer is a good idea, particularly to work out a schedule, with specific routine adjustments to mitigate triggers. This can help you be productive and healthy while working from home. Employers can also take the initiative -- arranging wellness programs for employees to raise awareness about migraines and how to effectively manage them at work and enhance productivity.
Migraine attacks can be challenging. Changes to your daily routine and active communication about your condition with your employer, after consulting a neurologist, can help you better manage migraines as you work from home.
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वैश्विक स्तर पर कैंसर से पीड़ित लगभग 20 प्रतिशत बच्चे, जो सार्स-सीओवी-2 यानी कोविड-19 से संक्रमित हुए हैं, उनमें कैंसर रहित बच्चों या लोगों की तुलना में अधिक गंभीर संक्रमण विकसित होता पाया गया है। द लैंसेट ऑन्कोलॉजी जर्नल में प्रकाशित एक अंतरराष्ट्रीय अध्ययन में खुलासा हुआ है।
हालांकि, कुल मिलाकर ऐसे केवल 1-6 प्रतिशत बच्चों में ही गंभीर संक्रमण पाया गया है।
अमेरिका के टेनेसी में सेंट जूड चिल्ड्रेन रिसर्च हॉस्पिटल के नेतृत्व में किए गए अध्ययन से पता चला है कि अधिक गंभीर या गंभीर संक्रमणों के अलावा, बाल चिकित्सा कैंसर रोगियों के अस्पताल में भर्ती होने की संभावना अधिक है, जो कि 65 प्रतिशत तक आंकी गई है।
इसके अलावा स्टडी के दौरान कैंसर से पीड़ित 17 प्रतिशत कोविड संक्रमित बच्चों को उच्च स्तर की चिकित्सा सुविधा के लिए भर्ती कराए जाने या स्थानांतरण की जरूरत पाई गई। वहीं गंभीर स्थिति के बाद मृत्यु की दर चार प्रतिशत आंकी गई है, जबकि सामान्य बाल रोगियों में 0.01-0.7 प्रतिशत मृत्यु दर देखी गई है। यानी कैंसर से पीड़ित बच्चों की सामान्य संक्रमित बच्चों से तुलना करें तो जिंदगी से जंग हारने के मामले में भी कैंसर पीड़ित बच्चे कहीं अधिक संवेदनशील पाए गए हैं।
यह भी देखने में आया है कि महामारी ने कैंसर के इलाज को भी बाधित कर दिया है। 56 प्रतिशत रोगियों में कैंसर चिकित्सा को संशोधित किया गया है और 45 प्रतिशत ने कीमोथेरेपी को रोक दिया, क्योंकि साथ ही उनका संक्रमण का इलाज भी किया जा रहा था।
इन प्रभावों को निम्न और मध्यम आय वाले देशों में अधिक महत्वपूर्ण रूप से देखा गया, जहां कोविड-19 से गंभीर बीमारी की संभावना उच्च आय वाले देशों की तुलना में लगभग छह गुना अधिक देखने को मिली है।
सेंट जूड डिपार्टमेंट ऑफ ग्लोबल पीडियाट्रिक मेडिसिन एंड इंफेक्शियस डिजीज की शीना मुक्काडा ने कहा, "नतीजे स्पष्ट और निश्चित रूप से दिखाते हैं कि कोविड-19 के साथ कैंसर से पीड़ित बच्चों की कैंसर रहित बच्चों की तुलना में बदतर स्थिति होती है।"
विश्लेषण में 15 अप्रैल, 2020 से 1 फरवरी, 2021 तक 45 देशों के 131 अस्पतालों के 1,500 बच्चों को शामिल किया गया। यह स्टडी ऐसे समय पर हुई, जब दुनिया के कुछ क्षेत्रों में बड़े बच्चों के लिए टीकाकरण उपलब्ध नहीं हुआ था। इसके अलावा उस समय तक काफी जगह पर डेल्टा सहित विभिन्न प्रकार के नए कोविड-19 वैरिएंट भी सामने नहीं आए थे, जो कि कई देशों में तेजी से बढ़ते मामलों के लिए जिम्मेदार पाए गए हैं और एक प्रमुख वैश्विक चिंता बन गए हैं।
शोध में शामिल विशेषज्ञों ने कोविड-19 के खिलाफ बच्चों को टीकाकरण के महत्व पर जोर दिया है। बच्चे अपेक्षाकृत बीमारी के गंभीर रूपों से सुरक्षित पाए गए हैं, जिससे रोगियों को अस्पताल में भर्ती होने और वेंटिलेटर की आवश्यकता से बचने में मदद मिल सकती है।
यह भी पढ़े►प्राकृतिक कारणों से मृत्यु के जोखिम को कम कर सकता है नियमित व्यायाम
Washington, Aug 20 (IANS) The Covid-19 infection rate in prisons across the US has reached 34 per cent, an expert has said."Prisons and jails have hosted some of the largest Covid-19 outbreaks in the US, with some facilities approaching 4,000 cases... In US prisons, the (infection) rate is 34 out of 100," Danielle Wallace, associate professor of the School of Criminology and Criminal Justice at the Arizona State University, wrote in an article.The article was published in The Conversation, a Melbourne-based online media outlet that publishes news stories and articles by academics and researchers.A main reason for such a high Covid-19 infection rate is correctional officers, who have been playing a leading role in spreading infectious diseases for years, Wallace noted, calling them "a weak link"."Current prison conditions, including poor ventilation, overcrowding and a lack of space for social distancing, and isolation, make respiratory diseases like Covid-19 very difficult to control," she said, adding that many US states have remained at a prisoner capacity of at least 100 per cent during the pandemic.Wallace also attributed the high infection rate in US prisons to short staffing as well as low vaccination rates among correctional officers and incarcerated people."Across all states, incarcerated people have not been prioritised for the vaccine. Even when the vaccines are available, many incarcerated people are sceptical about receiving them due to mistrust of prison officials," she said.--IANSksk/
New York, Aug 18 (IANS) Despite causing a surge in infections that has resulted in thousands of hospitalisations and deaths, the Delta variant of Covid-19 is not particularly good at evading the antibodies generated by the Pfizer vaccine, according to a study.The findings, published in the journal Immunity, help explain why vaccinated people have largely escaped the worst of the delta surge.Researchers at Washington University in the US extracted antibody-producing cells from three people who had received the Pfizer vaccine. They grew the cells in the laboratory and obtained from them a set of 13 antibodies that target the original strain that began circulating last year.The researchers tested the antibodies against four variants of concern: alpha, beta, gamma and delta. Twelve of the 13 recognised alpha and delta, eight recognised all four variants, and one failed to recognise any of the four variants.Five of the 13 antibodies neutralised the original strain. When the team tested the neutralising antibodies against the new variants, all five antibodies neutralised delta, three neutralised alpha and delta, and only one neutralised all four variants."The fact that delta has outcompeted other variants does not mean that it's more resistant to our antibodies compared to other variants," said Jacco Boon, Associate Professor of medicine, of molecular microbiology and of pathology and immunology at the University's School of Medicine in St. Louis.The antibody that neutralised all four variants of concern -- as well as three additional variants tested separately -- was called 2C08. In animal experiments, 2C08 also protected hamsters from disease caused by every variant tested: the original variant, delta and a mimic of beta.Some people may have antibodies just as powerful as 2C08 protecting them against SARS-CoV-2 and its many variants, said Ali Ellebedy, Associate Professor of pathology and immunology, of medicine and of molecular microbiology, at the varsity.Using publicly available databases, the researchers discovered that about 20 per cent of people infected or vaccinated against SARS-CoV-2 create antibodies that recognise the same spot on the virus that is targeted by 2C08. Moreover, very few virus variants (.008 per cent) carry mutations that allow them to escape antibodies targeting that spot."The ability of a variant to spread is the sum of many factors. Resistance to antibodies is just one factor. Another one is how well the variant replicates. A variant that replicates better is likely to spread faster, independent of its ability to evade our immune response. So delta is surging, yes, but there's no evidence that it is better at overcoming vaccine-induced immunity compared to other variants," Boon said.--IANSrvt/dpb
Jerusalem, Aug 15 (IANS) Serious Covid-19 cases in Israel crossed the 500 mark on Sunday, for the first time since March, media reports said.According to the Health Ministry, there were 524 patients in serious condition, with 84 of them on ventilators. In total, there were 877 people hospitalised with Covid-19, the Times of Israel reported.The rate of serious cases was far higher among the unvaccinated older adults above 60, who constituted 134.1 people per 100,000 in serious condition on Saturday, while among the vaccinated, the figure was 20, and among the partially vaccinated, 35.5.Seven deaths on Saturday and a further fatality since midnight took the reported death toll since the start of the pandemic to 6,632, the report said.Warning that Israel was facing "tough days" ahead due to the resurgence in coronavirus cases, Prime Minister Naftali Bennett, however, pushed back on calls for another national lockdown to stem the rising morbidity."Everything possible is being done to avoid lockdowns, which are destructive tools for our livelihood, for the economy, and for the education of our children," he wrote in a lengthy Facebook post. "Lockdowns are a last resort."Israel, last month, rolled out booster shots to adults over 60. Last week, the shots were extended to people older than 50.As of Sunday morning, 866,315 people in Israel had received the booster. Over 5.8 million had received at least one vaccine dose, and more than 5.4 million had gotten two, the report said.As a result, the number of serious patients in Israel is expected to drop already in the coming days."In the coming week, we hope to see signs of a decrease in serious morbidity among people over 60 who are seriously ill," Health Ministry's Director General, Prof Nachman Ash, was quoted speaking to FM 103 Radio, part of The Jerusalem Post Group."We have preliminary information on the effect of the third vaccine against infection," he added. "We estimate that this has halved the number of cases among the vaccinated, and in the coming days, we will have to see that this trend is maintained and this is also reflected in the serious morbidity," Ash said.--IANSrvt/vd
Beijing, Aug 15 (IANS) Researchers have identified that low microRNA (miRNA) immunity increases the risk of Covid-19 infection in older adults and people with diabetes.MicroRNAs are a key class of gene expression regulators which play an important role in inflammation and immune response.The study led by researchers from Nanjing University in China identified four circulating miRNAs -- miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p -- which are high in healthy people and much lower in older people and diabetic patients.These miRNAs could effectively inhibit SARS-CoV-2 replication by directly targeting the S protein, said Chen-Yu Zhang from the varsity's School of Life Sciences.Serum exosomes containing these miRNAs from young people could strongly inhibit SARS-CoV-2 replication, but this inhibitory effect was low in older people and diabetic patients, the researchers said.Long-term exercise was found to increase the level of these miRNAs in the blood offering better protection against the SARS-CoV-2 virus.The team found that three out of the four circulating miRNAs are significantly increased in the serum of healthy volunteers after 8-weeks' continuous physical exercise. Serum exosomes isolated from these volunteers also showed stronger inhibitory effects on S protein expression and SARS-CoV-2 replication.The study also provides an interesting observation that continuous physical exercise could boost miRNA immunity against SARS-CoV-2, which gives you another reason to hit the gym after work. Working out every day would therefore help all of us, old or young, to stay out of Covid-19's way.Further, the findings, detailed in the journal Signal Transduction and Targeted Therapy, also demonstrates for the first time that our own endogenous miRNAs could directly inhibit SARS-CoV-2 virus.Previous studies led by the tema have shown that approximately 89 per cent of viruses that infect humans could be targeted by human miRNAs. The new study provides strong and direct evidence supporting the theory that miRNAs, particularly extracellular miRNAs, could function as "RNA defense" and protect cells against foreign nucleic acids, Zhang said.The study indicates that miRNAs are an important component of the endogenous RNA-based immune system to fight virus infection. This new understanding of miRNA function may provide new perspectives for prevention, surveillance and treatment of Covid-19, Zhang added.--IANSrvt/dpb