Many young and middle-aged people today are dying of sudden heart attacks. Studies show that cardiovascular diseases (CVD) strike Indians a decade earlier compared to their Western counterparts.
Why is this happening? How can we prevent it? Are we just focused on post-heart attack action? Or should we be focused more on prevention?
Luke Coutinho, Holistic Lifestyle Coach Integrative and Lifestyle Medicine shares an input that could prevent heart attacks at a young age:
Cholesterol is not the culprit, inflammation is: Many people believe that high levels of cholesterol and triglycerides are the sole culprits behind their heart attacks. The main reasons behind most heart attacks are inflammation and oxidative damage in the heart, blood vessels, endothelial lining, arteries, and more. While maintaining healthy cholesterol levels is important, we cannot blame heart attacks on cholesterol levels alone.
What then can you do to keep inflammation in check and your heart strong? Adopt simple lifestyle changes.
Switch From Ordinary Substandard Cooking Oils to Cold-Pressed Oils: Refined oils are highly inflammatory and a threat to your heart. Using refined oils just to save some money isn't a wise idea. Choose the right quality and quantity of oil to boost your heart health. It might cost you a few extra bucks, but remember, your health is not a cost but an investment.
Switch From A Sedentary Lifestyle to An Active One: Even if you don't engage in a full-fledged workout, just stay active. Walking and yoga are the most effective exercises. Choose fun workouts that you enjoy -- dancing, aerobics, Zumba, swimming, whatever it is, but keep that body moving. People who live a sedentary lifestyle are at high risk of heart attacks. Having said that, over-working out with little or no rest or recovery period is equally harmful. So, figure out the adequate level of activity your body needs and stick to it.
Don't Take Matters to Your Heart: Before renting out your heart space and mind space to a person, event or experience, ask yourself if it is worth it. While stress is inevitable, what sets a happy person apart from a stressed person is their capacity to diffuse and navigate stress and see things in a positive light. You can continue attending stress management classes and workshops, and while all of them can help you feel better for some time, the real change happens when you start changing your perspective towards life and how you relate to stress.
Learn to accept and let go. Build your self-worth, create a beautiful inner world, reflect inwards, and allow these teachings to slip into your daily living.
Fix Your Sleep Routine: There is nothing cool about pulling an all-nighter to work or socialize more. Your body only cares about survival. Remember, your sleep is your heart's free drug. The chronic deprivation of it can increase your risk of a heart attack. Your heart is a muscle that needs recovery. Lack of sleep increases your insulin resistance and makes you more prone to type-2 diabetes and a gamut of metabolic conditions. So, adopt a fixed sleeping schedule and sleep deep.
We cannot wait for more misfortunate incidents to realize the importance of lifestyle and start prioritizing it. We must wake up and work towards prevention. Many of us may go through heart disease later in life, no matter how well we exercise or eat clean. So, identify risk factors and work towards tackling them. Even if one of your risk factors is genetic predisposition and there is nothing you can do about it, you can still alter your lifestyle. Our intelligent human body was designed to fix and heal itself. The least we can do is invest in it and help it do its job effectively. Lifestyle can help you bridge this gap.
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Hyderabad, July 27 (IANS) Cells communicate with each other via receptor proteins expressed on the cell membranes, and many drugs target these receptor proteins to alter the cell's functioning and physiology. However, the latest study from Prof Amitabha Chattopadhyay's lab at CSIR-Centre for Cellular and Molecular Biology (CCMB) makes a case for accounting for the lipid environment that surrounds the receptor proteins, while designing drugs, acting on the latter.The lab had earlier found that the serotonin receptors are sensitive to cholesterol surrounding them. In the new study published in Science Advances, they report a sensor region on human serotonin1A receptor that can detect cholesterol. They looked at specific regions called CRAC motifs, believed to interact with cholesterol, in the receptor. The researchers carefully replaced specific amino acids in the CRAC motifs of the serotonin1A receptor, and identified a particular amino acid responsible for cholesterol-sensitive function of the receptor.The researchers collaborated with Dr Jana Selent's group from Pompeu Fabra University Hospital del Mar Medical Research Institute in Spain's Barcelona to visualise the protein-cholesterol interaction via computer-aided molecular dynamics simulations. This helped them predict how the specific amino acid on CRAC motif enables the receptor to sense changes in cholesterol levels by controlling molecular motion in certain regions of the receptor."These findings are important since cholesterol levels change in our cells with age and in many disease conditions. We believe our work will help in developing better drugs that keep in mind not just the receptor as the drug target, but also the lipid environment in which the receptor is present," said Prof Chattopadhyay."Our expertise in structural biology at the CCMB is key towards physical understanding of cells and their functions. This not only adds to the detailed view of living cells but also have immense potential in therapeutics development," CCMB Director, Dr Vinay Nandicoori, said.--IANSms/vd
New York - Researchers have identified a type of "good cholesterol" that protects the liver by blocking inflammatory signals produced by common gut bacteria.
High-density lipoprotein (HDL) is mostly known for mopping up cholesterol in the body and delivering it to the liver for disposal.
But researchers from the Washington University in St Louis, the US, found that a type of "good cholesterol" called HDL3, when produced in the intestine, protects the liver from inflammation and injury. If not blocked, these bacterial signals travel from the intestine to the liver, where they activate immune cells that trigger an inflammatory state, which leads to liver damage.
"Even though HDL has been considered 'good cholesterol,' drugs that increase overall HDL levels have fallen out of favour in recent years because of clinical trials that showed no benefit in cardiovascular disease," said Gwendalyn J. Randolph, Professor of Immunology at the University's School of Medicine.
"But our study suggests that raising levels of this specific type of HDL, and specifically raising it in the intestine, may hold promise for protecting against liver disease, which, like heart disease, also is a major chronic health problem," Randolph added.
The study, published in the journal Science, showed that HDL3 from the intestine protects the liver from inflammation in mice and in human blood samples.
Any sort of intestinal damage can impact how a group of microbes called Gram-negative bacteria can affect the body. Such microbes produce an inflammatory molecule called lipopolysaccharide that can travel to the liver via the portal vein.
The portal vein is the major vessel that supplies blood to the liver, and it carries most nutrients to the liver after food is absorbed in the intestine.
Substances from gut microbes may travel along with nutrients from food to activate immune cells that trigger inflammation. In this way, elements of the gut microbiome may drive liver disease, including fatty liver disease and liver fibrosis, in which the liver develops scar tissue.
"We are hopeful that HDL3 can serve as a target in future therapies for liver disease. We are continuing our research to better understand the details of this unique process," Randolph said. (IANS)
New York,Patients taking statin medications -- commonly used to reduce blood cholesterol levels -- are at a 41 per cent lower risk of in-hospital death from Covid-19, researchers have found.
Statins block liver enzymes responsible for making cholesterol. The US Centers for Disease Control and Prevention estimates that 93 per cent of patients who use a cholesterol-lowering drug use a statin.
The use of statins or an anti-hypertension medication was associated with a 32 per cent lower risk of death among Covid-19 inpatients with a history of cardiovascular disease or hypertension.
This is because statins and anti-hypertension medications stabilise the underlying diseases for which they are prescribed, making patients more likely to recover from Covid-19, according to researchers from the University of California San Diego.
In the study, published in the journal PLOS ONE, the research team analysed anonymised medical records of 10,541 patients admitted for Covid-19 over a nine-month period, January through September 2020, at 104 different hospitals in the US.
"From this data, we performed more advanced analyses as we attempted to control for coexisting medical conditions, socioeconomic status and hospital factors," said lead author Lori Daniels, Professor and director of the Cardiovascular Intensive Care Unit at the varsity's School of Medicine.
"In doing so, we confirmed our prior findings that statins are associated with a reduced risk of death from Covid-19 among patients hospitalised for Covid-19," Daniels added.
The ACE2 receptor -- the regulatory target of statins -- helps control blood pressure. In 2020, it was discovered that SARS-CoV-2 virus primarily uses the same receptor to enter lung cells.
"As with any observational study, we cannot say for certain that the associations we describe between statin use and reduced severity of Covid-19 infection are definitely due to the statins themselves; however, we can now say with very strong evidence that they may play a role in substantially lowering a patient's risk of death from Covid-19," said Daniels.
"We hope that our research findings are an incentive for patients to continue with their medication." (IANS)
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मुंबई, दिन में दो बार बादाम खाने से ग्लूकोज मेटाबॉलिज्म में सुधार के साथ-साथ कोलेस्ट्रॉल के स्तर को भी नियंत्रित रखने में मदद मिल सकती है। ये जानकारी एक अध्ययन से सामने आई है।
अध्ययन से पता चला है कि बादाम का सेवन मधुमेह के पूर्व चरण में ब्लड शुगर के स्तर में सुधार कर सकता है, जो मधुमेह के विकास को रोकने या देरी करने में मदद कर सकता है।
इसके अलावा, बादाम के सेवन से कुल कोलेस्ट्रॉल और ऐसबैड एलडीएल-कोलेस्ट्रॉल को भी नियंत्रण समूह की तुलना में काफी कम कर दिया, जबकि अच्छा एचडीएल-कोलेस्ट्रॉल के स्तर को बनाए रखा गया।
मुंबई में सर विथाल्डिस ठाकरसे कॉलेज ऑफ होम साइंस में प्रोफेसर और प्रिंसिपल जगमीत मदन ने कहा किशोरावस्था और युवा वयस्कों पर लक्षित बेहतर पोषण और व्यायाम सहित जीवनशैली में बदलाव में प्रीडायबिटीज से टाइप -2 मधुमेह की प्रगति को रोकने की क्षमता है। इस अध्ययन के परिणाम बताते हैं कि परिवर्तन एक प्रमुख नहीं है, बस एक बादाम के दो बार के नाश्ते से फर्क पड़ सकता है।
मदन ने कहा, अध्ययन के परिणाम यह दिखाने में बहुत आशाजनक हैं कि कैसे बादाम ने कुल और एलडीएल-कोलेस्ट्रॉल के स्तर में सुधार किया और एचबीए 1 सी के स्तर को केवल 12 सप्ताह में कम कर दिया।
अध्ययन के लिए, टीम में बिगड़ा हुआ ग्लूकोज चयापचय (प्रीडायबिटीज) के साथ 275 प्रतिभागियों (59 पुरुष, 216 महिला) को शामिल किया गया था।
बादाम समूह ने तीन महीने तक हर दिन 56 ग्राम (लगभग 2 औंस सविर्ंग्स, या लगभग 340 कैलोरी) बिना भुना हुआ बादाम खाया और नियंत्रण समूह ने पूरे गेहूं के आटे, बेसन, नमक और भारतीय मसालों का उपयोग करके कैलोरी की समान संख्या के साथ एक स्वादिष्ट नाश्ता खाया।
प्रतिभागियों के कुल कैलोरी सेवन में बादाम और नमकीन दोनों तरह के स्नैक्स का हिस्सा लगभग 20 प्रतिशत था।
बादाम समूह में, एचूबीए 1 सी - दीर्घकालिक ब्लड शुगर नियंत्रण का एक उपाय जो कि
प्रीडायबिटीज और मधुमेह के लिए क्लीनिकल मानदंड के रूप में भी कार्य करता है - नियंत्रण समूह की तुलना में काफी कम हो गया। नियंत्रण समूह की तुलना में बादाम समूह में उपवास ब्लड शुगर में कमी थी, लेकिन सांख्यिकीय रूप से महत्वपूर्ण नहीं थी। (आईएएनएश)
New York, May 28 (IANS) People with genetic high cholesterol, heart disease or both, and infected with Covid-19 can be more at risk of heart attacks, according to new research.Familial hypercholesterolemia (FH) is a common genetic condition that increases an individual's risk for cardiovascular disease by up to 20-fold due to lifelong elevated low density lipoprotein cholesterol (LDL-C) levels.The study, published in the American Journal of Preventive Cardiology, also confirms that Covid-19 increases heart attack rates in individuals with established atherosclerotic cardiovascular disease (ASCVD)."Probable FH" individuals with pre-existing ASCVD who contracted Covid had heart attacks at a seven-times greater annual rate than their counterparts who did not contract the virus, the researchers said."This study is a call to action to diagnose individuals with this deadly genetic condition who are hiding in plain sight within our healthcare system, and take particular precautions related to Covid-19 infections. FH is an untapped opportunity for heart disease prevention," said Mary McGowan, chief medical officer for the FH Foundation.For the study, the team performed an analysis of 55,412,462 individuals, separating groups into six matched cohorts including diagnosed FH, probable FH, and ASCVD, with and without Covid-19 infection.The researchers found that rates of heart attacks were highest in those with a Covid-19 diagnosis and the presence of diagnosed FH or probable FH with known ASCVD."These results are significant because these data underscore the importance of understanding if individuals have underlying cardiovascular disease or genetic high cholesterol when treating for Covid-19 infection or considering vaccination," said Kelly Myers, chief technology officer of the FH Foundation.--IANSrvt/sdr/