Bhopal- A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have in a review identified the biomolecular relationships between Covid-19, ageing, and diabetes.
The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity and ageing can potentially be used to treat Covid-19. Similar naturally existing biomolecules were also explored in combination for the Covid treatment.
"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.
Some other polyphenols that the researchers have identified as being useful for both Covid-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).
The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the Covid-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is a drug Metformin , which is usually used to control blood sugar.
The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and Covid-19. All three conditions are associated with oxidative stress and lowering of the immune response and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).
The researchers believe that an ideal therapeutic candidate for Covid-19 should be able to target the pathways that are common to diabetes, ageing and the SARS-CoV-2 infection.
Further, computational studies showed that lipids present in cell membranes play an important role in coronavirus infectivity.
Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.
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इंडियन काउंसिल ऑफ मेडिकल रिसर्च (आईसीएमआर) द्वारा तैयार की गई एक रिपोर्ट में कहा गया है कि 2012-19 के बीच कैंसर के कुल मामलों में से 7.9 फीसदी 14 साल से कम उम्र के बच्चों में पाए गए। 'क्लिनिकोपैथोलॉजिकल प्रोफाइल ऑफ कैंसर्स इन इंडिया : ए रिपोर्ट ऑफ हॉस्पिटल-बेस्ड कैंसर रजिस्ट्रीज, 2021', नेशनल कैंसर रजिस्ट्री प्रोग्राम (एनसीआरपी) के तहत 96 अस्पताल-आधारित कैंसर रजिस्ट्रियों की अवधि के दौरान एकत्र किए गए डेटा को समेकित करता है। डेटा देशभर में इन केंद्रों को रिपोर्ट किए गए पुष्टिकृत विकृतियों के सभी निदान और इलाज के मामलों से संबंधित हैं।
देश में 2012-19 के दौरान कैंसर के 13,32,207 मामले दर्ज किए गए। इनमें से 6,10,084 को डेटा की पूर्णता और गुणवत्ता के आधार पर विश्लेषण के लिए शामिल किया गया था।
बचपन के कैंसर वैश्विक स्तर पर बचपन की बीमारियों के प्रमुख कारण के रूप में नौवें स्थान पर हैं, विकलांगता समायोजित जीवन वर्ष (डीएएलवाई) के 11.5 मिलियन के लिए जिम्मेदार है।
भारत में, एनसीआरपी की एक हालिया रिपोर्ट के अनुसार, सभी आयु समूहों में कैंसर के सापेक्ष बचपन के कैंसर (0-19 वर्ष) का अनुपात 1 से 4.9 प्रतिशत के बीच पाया गया।
दिल्ली में लड़कों में 203.1 प्रति मिलियन और लड़कियों में 125.4 प्रति मिलियन की उच्चतम आयु-समायोजित घटना दर (एएआर) दर्ज की। ल्यूकेमिया 0-14 वर्ष आयु वर्ग में दोनों लिंगों में सभी बचपन के कैंसर के लगभग आधे के लिए जिम्मेदार है (लड़कों में 46.4 प्रतिशत और लड़कियों में 44.3 प्रतिशत)। लड़कों में अन्य सामान्य बचपन का कैंसर लिम्फोमा (16.4 प्रतिशत) था, जबकि लड़कियों में यह घातक अस्थि ट्यूमर (8.9 प्रतिशत) था।
बचपन के कैंसर दो आयु समूहों के लिए प्रस्तुत किए जाते हैं : 0-14 वर्ष और 0-19 वर्ष राष्ट्रीय और अंतर्राष्ट्रीय तुलना को सक्षम करने के लिए और बचपन के कैंसर के अंतर्राष्ट्रीय वर्गीकरण के अनुसार वर्गीकृत किया जाता है।
रिपोर्ट में कहा गया है कि बचपन के कैंसर के अलावा, तंबाकू के उपयोग से जुड़े कैंसर में पुरुषों में 48.7 प्रतिशत और महिलाओं में 16.5 प्रतिशत कैंसर शामिल हैं।
थायरॉइड कैंसर (महिलाओं में 2.5 प्रतिशत बनाम पुरुषों में 1 प्रतिशत) और पित्ताशय के कैंसर (महिलाओं में 3.7 प्रतिशत बनाम पुरुषों में 2.2 प्रतिशत) को छोड़कर, साइट-विशिष्ट कैंसर का सापेक्ष अनुपात महिलाओं की तुलना में पुरुषों में अधिक था।
सभी कैंसरों में दूर के मेटास्टेसिस का उच्चतम अनुपात फेफड़ों के कैंसर (49.2 प्रतिशत पुरुष और 55.5 प्रतिशत महिलाओं) के रोगियों में देखा गया, इसके बाद पित्ताशय का कैंसर (40.9 प्रतिशत पुरुष और 45.7 प्रतिशत महिलाएं) और प्रोस्टेट कैंसर (42.9 प्रतिशत) का स्थान है।
रिपोर्ट ने सुझाव दिया कि कई कैंसर के लिए कीमोथेरेपी अभी भी सबसे विशिष्ट उपचार पद्धति थी, भले ही प्रस्तुति में रोग की नैदानिक सीमा कुछ भी हो, जिसमें यकृत, पित्ताशय, पेट, फेफड़े और बचपन के कैंसर शामिल हैं।
यह भी पढ़े► कैंसर और हार्ट अटैक से ज्यादा खतरनाक हो जाएगा सेप्सिस: शोध
Snoring can be frustrating and annoying, especially for those who sleep with a snorer. The National Sleep Foundation reports that one in three men and four women snore every night.
Though snoring is often overlooked as a minor issue, it can occur due to various reasons requiring immediate attention. Obesity or being overweight is one of the leading causes of snoring. Snoring accompanied by irregular breathing is a sign of cardiovascular disease risk. Sleep apnoea can be another condition that increases the chances of snoring. Sleep apnoea is a sleep disorder in which the breathing repeatedly stops and resumes again. Fortunately, plenty of remedies are available to treat snoring naturally without using over-the-counter (OTC) drugs.
Obesity or Excess Weight
For those who have started snoring after gaining weight, shedding some extra pounds can be quite helpful. Obese people tend to have excess tissue and fat in the neck region, which can reduce the airway size and elevate the risk of airway collapse. Studies have proved that weight reduction can eliminate the frequency of snoring with increased weight losses causing near to complete elimination of snoring.
Snoring accelerates when people lie in the supine position or on their backs. When someone lies down on the back, the tissues surrounding the airway are pulled down by gravity, making it narrow. Research and studies on snorers have revealed that the intensity and frequency of snoring reduce considerably when they lie on their sides.
Blocked Nasal Passages
Snoring can also be prevented by keeping the nasal passages open. When the nose is clogged or blocked, air moves in much faster, leading to snoring. Hot oil massages or nasal oil drops can open the blockages in the nose. Also, a hot shower before bed can be quite beneficial as the moisture opens the nasal passages and reduces the chances of snoring.
Staying hydrated is crucial not only to avoid snoring but also to maintain overall health and well-being. When the body is dehydrated, secretions in the nose and soft palate becomes stickier. This can obstruct the proper flow of air and cause snoring. For men, it is recommended to consume at least 3-4 litres of fluid every day, while women must consume 2-3 litres of fluids daily.
Smoking and Alcohol
Researchers believe that snoring in smokers can occur because of oedema and upper airway inflammation. While it takes time to show the effects but quitting smoking can significantly lessen the chances of snoring. Alcohol is another substance that relaxes the muscles around the airway, increasing the likelihood to snore among drinkers. Therefore, it is often recommended not to indulge in drinking in the hours leading to bedtime.
The tips mentioned above can bring positive results if tried daily. It is important to try them all to find the ideal remedy that helps.
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New York, Aug 16 (IANS) Regular exercise, even performed in areas with air pollution, can reduce the risk of death from natural causes, a new study suggests.The study, published in the journal CMAJ (Canadian Medical Association Journal), indicates that a higher level of regular exercise compared with inactivity was beneficial, even in polluted areas, although less exposure to pollution was better."Habitual exercise reduces the risk of death regardless of exposure to air pollution, and air pollution generally increases the risk of death regardless of habitual exercise," said researcher Xiang Qian Lao from the Chinese University of Hong Kong."Thus, habitual exercise should be promoted as a health improvement strategy, even for people residing in relatively polluted areas," Lao added.For the study, the team conducted a large study, over 15 years from 2001 to 2016, with 384,130 adults in Taiwan, seeking to understand the effects of regular exercise and long-term exposure to fine particle matter on the risk of death from natural causes. "We found that a high level of habitual exercise and a low level of exposure to air pollution was associated with lower risk of death from natural causes, whereas a low level of habitual exercise and a high level of exposure was associated with a higher risk of death," the researcher said.This study adds to several other smaller studies conducted in the US, Denmark and Hong Kong that found that regular exercise, even in polluted areas, is beneficial.The authors said that "further studies in areas with more severe air pollution are required to examine the applicability of our findings". "Our study reinforces the importance of air pollution mitigation, such as to reduce the harmful effects of air pollution and maximize the beneficial effects of regular exercise," the team said.--IANSvc/rs
New York, Aug 12 (IANS) Risk of Covid-19 may shift from older adults to younger children as the SARS-CoV-2 virus becomes endemic, according to new research.Once endemic in the global population, Covid-19 may behave like other common cold coronaviruses, affecting mostly young children who have not yet been vaccinated or exposed to the virus."Following infection by SARS-CoV-2, there has been a clear signature of increasingly severe outcomes and fatality with age," Ottar Bjornstad, of the Department of Biology at the Pennsylvania State University, said."Yet, our modeling results suggest that the risk of infection will likely shift to younger children as the adult community becomes immune either through vaccination or exposure to the virus," he said.Bjornstad explained that such shifts have been observed in other coronaviruses and influenza viruses as they have emerged and then become endemic. Historical records of respiratory diseases indicate that age-incidence patterns during virgin epidemics can be very different from endemic circulation."For example, ongoing genomic work suggests that the 1889-1890 pandemic, sometimes known as the Asiatic or Russian flu -- which killed one million people, primarily adults over age 70 -- may have been caused by the emergence of HCoV-OC43 virus, which is now an endemic, mild, repeat-infecting cold virus affecting mostly children ages 7-12 months old," Bjornstad noted.For the study, appearing in the journal Science Advances, the team developed what is known as a "realistic age-structured (RAS) mathematical model". They examined disease burden over immediate, medium and long terms -- 1, 10 and 20 years, respectively as well as for 11 different countries -- including China, Japan, South Korea, Spain, the UK, France, Germany, Italy, the US, Brazil and South Africa -- that differed widely in their demographics.Interestingly, due to variations in demographics, the model predicts different outcomes for different countries."Given the marked increase of the infection-fatality ratio with age, countries with older population structures would be expected to have a larger fraction of deaths than those with relatively younger population structures," said Nils Chr. Stenseth, Professor of ecology and evolution, University of Oslo."Consistent with this, for example, South Africa -- likely due, in part, to its younger population structure -- has a lower number of deaths compared to older populations such as Italy. We found that such 'death disparities' are heavily influenced by demographics. However, regardless of demographics, we predict a consistent shift of the risk to the young," he added.--IANSrvt/vd
New York, Aug 12 (IANS) Researchers have found an important clue to a rare but serious after-effect of Covid-19 among those broadly below 12, known as multisystem inflammatory syndrome in children or MIS-C.MIS-C is characterised by fever, pain, and inflammation of multiple organs including the heart, lungs, kidneys, skin, eyes, or gastrointestinal tract. The researchers from Mount Sinai Hospital in New York, US, reported that RNA sequencing of blood samples led to the discovery that specific infection-fighting cells of the immune system are downregulated in children with MIS-C, and that this is associated with a sustained inflammatory response -- a hallmark of infection with SARS-CoV-2, the virus that causes Covid-19. The study was published in Nature Communications.The team analysed pediatric cases of MIS-C and Covid-19 and found new exploratory pathways involving complex networks and subnetworks of genes.One of the more significant of these gene networks involved the suppression of two types of immune cells: natural killer (NK) cells and CD8+ T cells. Previous research has shown that when CD8+ T cells are persistently exposed to pathogens, they enter a state of "exhaustion," resulting in a loss of their effectiveness and ability to proliferate. The researchers in the new study specifically pointed to the CD8+ T cells being in this exhausted state, thus potentially weakening the inflammatory immune response. An increase in NK cells is also associated with exhausted CD8+ T cells."Our study implicated T cell exhaustion in MIS-C patients as one of the potential drivers of this disease, suggesting that an increase in both NK cells and circulating exhausted CD8+ T cells may improve inflammatory disease symptoms," said Noam Beckmann, Assistant Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. "Additionally, we found nine key regulators of this network known to have associations with NK cell and exhausted CD8+ T cell functionality," Beckmann said.Beckmann added that one of those regulators, TBX21, is a promising therapeutic target because it serves as a master coordinator of the transition of CD8+ T cells from effective to exhausted. --IANSrvt/in