A brain tumour develops when certain genes in a cell's chromosomes become faulty and cease to function properly. These genes typically regulate the rate at which the cell divides and repair genes that correct deficiencies in other genes, as well as genes that should cause the cell to self-destruct if the damage is irreparable.
A person may be born with a partial defect in one or more of these genes. Environmental factors may then cause additional mutilation. In a few other cases, however, environmental damage to the genes can be viewed as the sole factor.
Behavioural Changes That Brain Tumours Cause
Brain tumours and their treatments, in general, can alter a person's behaviour and ability to think. Patients' communication, concentration, and memory skills may suffer, and their personalities may shift. Brain tumours frequently cause personality changes and mood swings. Although the severity of these mood changes varies from person to person, it is relatively common for someone with a brain tumour to experience increased aggression and agitation.
A brain tumour may also cause weakness, dizzy spells, poor balance or lack of coordination, personality or behaviour changes, confusion, speech problems, and fits (seizures). However, it is critical to note that the impact of a brain tumour on quality of life is determined by whether the tumour is benign or malignant in nature.
In the case of benign tumours, there is little variation in the patient's quality of life. There may be neurological deficits that can be corrected with regular physiotherapy and rehabilitation. We can keep a close eye on tumour recurrence using serial imaging. In the event of a relapse, the patient may be subjected to radiation or surgery. To answer an underlying question, a benign tumour does not impair quality of life after the ailment has been contracted. Most tumours do not leave residual deficits, making it simple to return to normalcy with timely rehabilitation and psychotherapy.
The outcome of a malignant brain tumour is determined by the grade of the tumour itself. If the tumour is of Grade 1, the characteristic features that accompany it behave more or less like a benign tumour. However, chemotherapy and radiation are required for a Grade 4 tumour, which causes skin discoloration, hair loss, fatigue, and other physiological changes. As a result, people's quality of life suffers. Nonetheless, with the proper treatment and time, these changes are completely reversible.
One thing to remember, regardless of the nature of the tumour, is to maintain a positive attitude toward the illness itself. A strong mind-set greatly aids the patient in overcoming the trauma of having a cancerous brain tumour. A holistic, positive outlook on life can go a long way toward rehabilitating a post-ailment patient. Needless to say, family support and strength go a long way toward a fruitful and blissful life for the patient.
(Dr. Ravi Gopal Varma, Lead Consultant Neurosurgery & Program Director - Global Centre of Excellence in Neurosciences, Aster Hospitals Bangalore)
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Gulguluthikthakam Kashayam is an ayurvedic medicine that is mainly used to treat skin diseases, anemia, ulcers, thyroid, IBD, anxiety, stress, white spots, liver disease, and leucorrhoea. This formulation is in herbal decoction. It is an Ayurvedic formula whose key ingredients are neem, patola, vyaghri, Guduchi, vasa, patha, vidanga, etc. It is manufactured by the renowned Ayurvedic company Charak Pharma Private Limited.
Guggulutiktam Kashayam is 100% Ayurvedic and safe and available in liquid and tablet form in the market. Guggulutiktam Kashayam dosage depends on the ethos, age, gender, weight, and medical history of the patient. So let's start this article in which you will get complete information about the Guggulutiktam Kashayam.
Gulguluthikthakam Kashayam Ingredients
Gulguluthikthakam Kashayam Benefits
Gulguluthikthakam Kashayam benefits are here:
It is used to treat rheumatoid arthritis and gout.
It is used for non-healing wounds, deep wounds, abscesses, sinuses, and fistulas.
Useful in the treatment of psoriasis, atopic dermatitis, allergic dermatitis, and urticaria.
An excellent drug for all types of inflammation, especially those related to connective tissue, bones, and joints.
It is also beneficial in Vata-Kapha's predominant skin conditions.
Known for tuberculous glands, boils, scabies, eczema, syphilis, and anemia.
It is used to treat lumbar and cervical spondylosis.
In combination with antiviral drugs, it is used to treat hepatitis.
Postviral fever when the patient complains of body, muscle, and joint pain, and bursitis.
shoulder dislocation pain
Gulguluthikthakam Kashayam Side Effects
Gulguluthikthakam Kashayam is not known to have any side effects when used in the prescribed dosage. Do not use this information to diagnose or treat your issue without consulting with an Ayurvedic Doctor.
Gulguluthikthakam Kashayam Dosage and Anupan
Gulguluthikthakam Kashayam dosage and anupan about 2 to 4 tablets before food twice a day.
Gulguluthikthakam Kashayam Shelf Life
Gulguluthikthakam Kashayam shelf life is up to 5 years from the date of manufacturing.
Gulguluthikthakam Kashayam Storage & Safety Information
Gulguluthikthakam Kashayam storage and safety information are:
Read the label carefully before use
Protect from direct sunlight
Use under medical supervision
Store in a cool and dry place
Gulguluthikthakam Kashayam Frequently Asked Questions
Q. What is Gulguluthikthakam kashayam?
Ans. Guggulutiktam Kashayam is an ayurvedic medicine that is mainly used to treat skin diseases, anemia, ulcers, thyroid, IBD, anxiety, stress, white spots, liver disease, and leucorrhoea.
Q. How much shelf life has Gulguluthikthakam kashayam had?
Ans. Gulguluthikthakam kashayam shelf life is up to 5 years from the date of manufacturing.
Q. How to consume Gulguluthikthakam kashayam?
Ans. Recommended doses of Gulguluthikthakam kashayam for treating different diseases and health conditions vary. Gulguluthikthakam kashayam dosage and anupan about 2 to 4 tablets before food twice a day. Therefore, it is crucial to consult an Ayurvedic doctor as the appropriate dose may vary depending on age, body shape, and health condition.
Q. Is Gulguluthikthakam kashayam safe?
Ans. Yes, Gulguluthikthakam kashayam is a useful ayurvedic medicine that is beneficial in skin diseases, anemia, ulcers, thyroid, IBD, anxiety, stress, white spots, liver disease, and leucorrhoea.
Q. Does Gulguluthikthakam kashayam have any chemical ingredients?
Ans. Gulguluthikthakam kashayam is made from natural herbs like neem, patola, vyaghri, Guduchi, vasa, patha, vidanga, etc.
Q. What is Gulguluthikthakam kashayam used for?
Ans. Gulguluthikthakam kashayam is used for skin diseases, anemia, ulcers, thyroid, IBD, anxiety, stress, white spots, liver disease, and leucorrhoea.
Q. Does the Gulguluthikthakam kashayam work?
Ans. Yes, Gulguluthikthakam kashayam may play a beneficial role that helps in skin diseases, anemia, ulcers, thyroid, IBD, anxiety, stress, white spots, liver disease, and leucorrhoea.
Q. Is Gulguluthikthakam kashayam effective?
Ans. Yes, Gulguluthikthakam kashayam is an effective formula.
Q. Is the use of the Gulguluthikthakam kashayam safe for the stomach?
Ans. Gulguluthikthakam kashayam is considered safe for the stomach.
Q. Is Gulguluthikthakam kashayam addictive or habit-forming?
Ans. No, addictive or habit-forming is produced by Gulguluthikthakam kashayam.
Q. Can I take Gulguluthikthakam kashayam with alcohol?
Ans. The Gulguluthikthakam kashayam effect with alcohol is unknown because research has not been done yet on this.
Q. Does Gulguluthikthakam kashayam have any side effects?
Ans. Gulguluthikthakam kashayam is not known to have any side effects when used in the prescribed dosage. Do not use this information to diagnose or treat your issue without consulting with an Ayurvedic Doctor.
Gulguluthikthakam kashayam Reference
Ashtangahrudayam Chiktisasthana 21/57-60
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Having a portable air cleaner in the home can reduce the negative impacts of air pollution on brain development in children, says a new study.
The study, published in the journal Environmental Health Perspectives, found that the children born to mothers who had used the air cleaners had an average full-scale intelligence quotient (FSIQ) that was 2.8-points higher than the group that did not use an air cleaner during pregnancy.
"These results, combined with evidence from previous studies, strongly implicate air pollution as a threat to brain development," said researcher Ryan Allen from Simon Fraser University, in Canada. The team recruited 540 pregnant women in Ulaanbaatar, Mongolia to participate in the study.
Ulaanbaatar has some of the worst air quality in the world, well-exceeding guidelines set by the World Health Organisation (WHO).
The women were less than 18 weeks into their pregnancies and non-smokers who had not previously used air filtering devices in their homes. They were randomly assigned to either the control or intervention group.
The intervention group was provided with one or two HEPA filter air cleaners and encouraged to run the air cleaners continuously for the duration of their pregnancies. The air cleaners were removed from the home once the child was born.
The researchers later measured the children's FSIQ at four years of age. Children in the intervention group also had significantly greater average verbal comprehension index scores, which is consistent with results from previous observational studies.
The research suggests that a child's verbal skills may be particularly sensitive to air pollution exposure. (Agency)
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New York: Aerobic exercise, which includes brisk walking, swimming, running, or cycling, can help reprogramme the immune system to reduce tumour growth and amplify the effects of immunotherapy, finds a new study.
Published online in Cancer Cell, the study, which focussed on pancreatic cancer, provides new insight into how the mammalian immune system, designed to attack foreign invaders like bacteria, can also recognise cancer cells as abnormal.
Exercise-induced increases in levels of the hormone adrenaline cause changes to the immune system, according to researchers at New York University.
It includes the activity of cells that respond to signalling protein interleukin-15 (IL-15).
The study found that exercise promotes the survival of CD8 T cells sensitive to IL-15, and doubles the number of them homing to pancreatic ductal adenocarcinoma (PDAC) tumours in mice.
Such "effector" T cells have been shown by other studies to be capable of killing cancer cells. Other tests found that aerobic exercise for 30 minutes five times a week reduced the rate of cancer formation by 50 per cent in one mouse model of PDAC, and reduced tumour weight by 25 per cent in another model, in which mice ran on treadmills for three weeks.
In collaboration with The University of Texas MD Anderson Cancer Center, the study authors then found that human patients who exercised before surgery to remove their pancreatic tumours had more CD8 effector T cells that expressed a protein called granzyme B, which confers tumour-cell killing ability.
Patients who exercised and had more of these cell types, had 50 per cent higher overall survival over five years than patients with fewer of them.
"Our findings show, for the first time, how aerobic exercise affects the immune microenvironment within pancreatic tumours," said first author Emma Kurz, a graduate student at NYU Grossman School of Medicine.
"The work helped to reveal that activation of IL-15 signalling in pancreatic cancer might be an important treatment approach in the future." (Agency)
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New York: Scientists have demonstrated that normal brain ageing is accelerated by approximately 26 per cent in people with progressive Type 2 diabetes compared with individuals without the disease, according to a study.
There is already strong evidence linking Type 2 diabetes with cognitive decline, yet few patients currently undergo a comprehensive cognitive assessment as part of their clinical care.
The results, published today in eLife, suggest that by the time Type 2 diabetes is formally diagnosed, there may already be significant structural damage to the brain. The findings also suggest that the patterns of Type 2 diabetes-related neurodegeneration strongly overlap with those of normal ageing, but that neurodegeneration is accelerated.
Sensitive ways to detect diabetes-associated changes to the brain are therefore urgently needed.
"Routine clinical assessments for diagnosing diabetes typically focus on blood glucose, insulin levels and body mass percentage," said Botond Antal, a doctoral student at the Department of Biomedical Engineering, Stony Brook University, US.
"However, the neurological effects of Type 2 diabetes may reveal themselves many years before they can be detected by standard measures, so by the time Type 2 diabetes is diagnosed by conventional tests, patients may have already sustained irreversible brain damage," Antal added.
The team evaluated the relationship between typical brain ageing and that seen in Type 2 diabetes from a dataset, which includes brain scans and brain function measurements, of 20,000 people aged 50 to 80 years old. The results were then compared with a meta-analysis of nearly 100 other studies.
Their analysis showed that both ageing and Type 2 diabetes cause changes in executive functions such as working memory, learning and flexible thinking, and changes in brain processing speed.
However, people with diabetes had a further 13.1 per cent decrease in executive function beyond age-related effects, and their processing speed decreased by a further 6.7 per cent compared to people of the same age without diabetes.
Further, MRI scans of people with and without diabetes showed that people with diabetes had even more pronounced decreases in gray matter beyond the typical age-related effects -- a further 6.2 per cent decrease in grey matter in the ventral striatum, but also loss of grey matter in other regions, compared with normal ageing.
"Our findings suggest that Type 2 diabetes and its progression may be associated with accelerated brain ageing, potentially due to compromised energy availability causing significant changes to brain structure and function," said Lilianne Mujica-Parodi, at the varsity's Director of the Laboratory for Computational Neurodiagnostics.
"By the time diabetes is formally diagnosed, this damage may already have occurred. Our results underscore the need for research into brain-based biomarkers for Type 2 diabetes and treatment strategies that specifically target its neurocognitive effects," Mujica-Parodi noted. (Agency)
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A combination of high-dose Vitamin D, Omega-3s, and simple home strength exercises can help reduce cancer risk in healthy adults aged 70 or older by 61 per cent, claims a study.
Published in Frontiers in Aging, it is the first study to test the combined benefit of three affordable public health interventions for the prevention of invasive cancers that has grown past the original tissue or cells where it developed, and spread to otherwise healthy surrounding tissue.
Apart from preventative recommendations such as not smoking and sun protection, public health efforts that focus on cancer prevention are limited, according to Dr Heike Bischoff-Ferrari of the University Hospital Zurich in Switzerland.
"Preventive efforts in middle-aged and older adults today are largely limited to screening and vaccination efforts," Bischoff-Ferrari noted.
Studies have shown that Vitamin D inhibits the growth of cancer cells. Similarly, Omega-3 may inhibit the transformation of normal cells into cancer cells, and exercise has been shown to improve immune function and decrease inflammation, which may help in the prevention of cancer.
However, there was a lack of robust clinical studies proving the effectiveness of these three simple interventions, alone or combined.
Bischoff-Ferrari and her colleagues tested the effect of daily high-dose Vitamin D3 (one form of Vitamin D supplements), daily supplemental Omega-3s, and a simple home strength exercise, alone and in combination, on the risk of invasive cancer among adults aged 70 or older.
The three-year trial, held in Switzerland, France, Germany, Austria, and Portugal, involved 2,157 participants.
The results show that all three treatments (Vitamin D3, Omega-3s, and exercise) had cumulative benefits on the risk of invasive cancers, Bischoff-Ferrari said.
Each of the treatments had a small individual benefit but when all three treatments were combined, the benefits became statistically significant, and the researchers saw an overall reduction in cancer risk by 61 per cent.
"Our results, although based on multiple comparisons and requiring replication, may prove to be beneficial for reducing the burden of cancer," Bischoff-Ferrari said, adding the need for further studies. (agency)
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