Hyderabad, Aug 10 (IANS) In good news for childless couples, scientists from Hyderabad, Mangalore and Manipal have designed an organic molecule that boosts functional competence of sperms used for in vitro fertilisation (IVF).The small organic molecule mPTX has been developed by Rajakumara Eerappa's group from the Department of Biotechnology, IIT Hyderabad; Jagadeesh Prasad Dasappa's group from Mangalore University; and Guruprasad Kalthur's group from the Kasturba Medical College, Manipal Academy of Higher Education.Their studies have shown that mPTX, a pentoxifylline derivative, is able to increase sperm motility, extend in vitro sperm survival, and improve sperm fertilisation potential, without adversely affecting the development of the embryos at much lower concentration compared to the widely used pharmacological agent -- pentoxifylline in IVF technology.Compared to the existing drugs, the mPTX molecule is potentially a better pharmacological agent for assisted reproductive technology. Rajakumara Eerappa, Associate Professor, Department of Biotechnology, IIT-H, said, "Our multi-institutional collaborative team is coming up with a formulation, using the combination of this mPTX and other molecules, that could be more effective than the existing formulation for the IVF procedure."With an estimated 48 million infertile couples worldwide, reduction in sperm motility is one of the major causes of male infertility. Motility is essential for sperms to reach the site of fertilisation during natural conception. Moreover, the percentage of motile spermatozoa present in ejaculation helps decide the ideal artificial insemination method such as IVF for infertility treatment.Pentoxifylline treatment increases sperm motility which goes hand in glove with the undesirable premature acrosomal reaction, which together determines the success of IVF. The purpose of this DST-SERB funded project was to improve the efficacy of pentoxifylline and to reduce its adverse effects on sperms competence and embryo development.Speaking on the technological advancement, B.S. Murty, Director of IIT Hyderabad, said, "The joy of parenthood can't be defined in words. The work led by Rajakumara Eerappa and his collaborators can bring the happiness of being parents in the infertile couples, by increasing the success rate of IVF. "IIT-H is a one of its kind institute to have both biomedical and biotechnology departments separately nurturing the talents. This also demonstrates the power of synergistic collaborations. I am confident that many such technologies significantly impacting the society will keep getting developed at IIT-H continuously."--IANSpvn/arm
Lucknow, July 14 (IANS) A 43-year-old man, who underwent a liver transplant in the surgical gastroenterology department of King George's Medical University (KGMU) last month, has been discharged after recovery. This was the first liver transplant in the university after Covid-19 pandemic outbreak and done almost free.Prof Abhijeet Chandra, head, surgical gastroenterology, said, "It was a challenge to conduct the transplant in limited resources. Five more patients are waiting in the queue and next transplant will be done in another 15 days."The patient, who was discharged on Tuesday, is a small-time shopkeeper with meagre financial means.He was unable to afford the transplant at a private hospital where it costs between Rs 30-40 lakh.In KGMU, the transplant was funded by the UP government's Asadhya Rog scheme and another donation of Rs 4 lakh came from Awadh International Foundation.Prof Chandra said that the patient was suffering from advanced stage liver cirrhosis with severe jaundice and bleeding.His wife donated a part of her liver and was discharged after a week. Post-transplant, about four-six litres of fluid was drained daily from the patient's abdomen for a few days, till the liver grew to the normal size.KGMU spokesperson Dr Sudhir Singh said that KGMU has conducted 11 liver transplants so far with over 90 per cent success rate.It is the only medical institute in UP to perform multi-organ donation and has provided over 50 cadaveric organs to other institutes in north India for needy patients.The transplant team comprising over 100 doctors/staff was led by vice-chancellor Lt Gen (retd) Dr Bipin Puri.The surgical gastroenterology team included Prof Chandra and Prof Vivek Gupta.--IANS amita/skp/
London, June 28 (IANS) The ovarian reserve of women previously infected with SARS-CoV-2, the virus causing Covid-19, is not adversely affected, and their chance of success from fertility treatment remains as it was before the infection, finds a study.Ovarian reserve describes the ability of the ovary to produce eggs for fertilisation (natural and medical) and pregnancy.The study, led by researchers at IVI Madrid, a fertility clinic in Spain, provides further reassurance for those planning fertility treatment with IVF. The findings were presented at ESHRE's 37th annual meeting taking place online from 26 June to July 1.The study described intrauterine infection via placental or congenital routes as unlikely, and reported that perinatal infection found at and after delivery was a more likely explanation for any neonatal infection.The team monitored hormone levels, in all 46 women having IVF in Spain between May and June 2020, which included measurements of anti-Mullerian hormone (AMH) -- a marker of ovarian reserve. AMH has become a widely used measurement in fertility clinics in recent years, able to predict how patients might respond to ovarian stimulation in IVF.It suggested they would be normal or low responders to ovarian stimulation when treatment began."Generally, the data showed no variation in AMH levels before and after SARS-CoV-2 infection, and we could assume that the chances of success in their fertility treatment remained intact," said Dr Maria Cruz Palomino from IVI Madrid.However, the results did show a slight decline in AMH measurements in those predicted to be normal responders, which Palomino said was not a "radical decrease" and unlikely to compromise ovarian reserve -- nor, she added, "can we attribute this variation to SARS-Cov-2 infection".There have been concerns because the virus invades its target cells by binding to the ACE2 receptor, which is widely expressed in the ovaries (as well as the uterus, vagina and placenta). This has caused some anxiety for women contemplating fertility treatment.But the study suggests that, while there was a variation in levels of AMH as a marker of ovarian reserve, this variation appeared dependent on patient response to ovarian stimulation, not on previous infection. "Nevertheless, we could assume that the chances of success of fertility treatment remain intact," said Palomino.--IANSrvt/arm
New Delhi, June 25 (IANS) The Union Ministry of Health and Family Welfare on Friday dispelled rumours that Covid vaccines cause infertility, saying that most of the people who receive the shots do not face any side-effects post inoculation, but it does not mean that the jabs are not effective.Covid vaccines do not cause infertility, the ministry said in a statement."At least six different types of Covid-19 vaccines will be available in India soon. We expect to procure 30-35 crore doses in a month to be able to vaccinate 1 crore persons in a day," the ministry said.N.K. Arora, Chairman, National Technical Advisory Group on Immunisation in India (NTAGI), said: "When the polio vaccine came and was being administered in India and other parts of the world, this sort of a rumour had spread at that time too. At that time, a misinformation was created that children who are getting polio vaccine may face infertility in the future."This sort of wrong information is spread by the anti-vaccine lobby. We should know that all vaccines go through intense scientific researches.""None of the vaccines has this sort of a side-effect. I would like to fully assure everyone that this sort of propaganda only misguides people. Our main intention is to save ourselves, our families and the society from coronavirus," he added.Arora further said that if the efficacy of a vaccine is 80 per cent, 20 per cent of the vaccinated people may contract mild Covid. The vaccines available in India are capable of reducing the spread of the virus. If 60-70 per cent people are vaccinated, the spread of the virus can be checked, Arora said.He said that as far as side-effects are concerned, all vaccines have mild side-effects. This includes mild fever, fatigue, pain in the injection site, for a day or two. It does not cause any serious problems.Most people do not face any side-effect after Covid vaccination, but it does not mean that vaccines are not efficient. Only 20-30 per cent people are going to experience fever after vaccination. Some people may get fever after the first dose and not have any fever after the second dose and vice-versa. It varies from person to person and it is highly unpredictable, experts said..--IANSmiz/sdr
A recent evaluation of the Centres of Excellence (CoE) scheme of the AYUSH Ministry carried by the Centre for Market Research and Social Development (CMRSD), New Delhi has lauded the scheme for its innovative and creative projects that are promoting AYUSH-based healthcare solutions in different parts of the country. The evaluation study further noted that all the CoEs have credible governance structures and have also raised competent groups of core staffs in the fields in which the projects function.
Under the CoE Scheme of the Ministry of AYUSH, support is provided to reputed AYUSH institutions for upgrading their functions and facilities to levels of excellence. The Centres of Excellence selected under this Scheme are the institutions that engaged in activities like Clinical Research, AYUSH Healthcare (hospitals), Research based on the fundamentals of AYUSH, Inter-disciplinary research in areas like pharmacognosy and pharmacology, Product development and bridging AYUSH and modern science.
The evaluation covered 18 Centres of Excellence from 10 different States, including Himachal Pradesh, Maharashtra, West Bengal and Kerala. The purpose of the evaluation exercise was to assess the impact of the CoEs in achieving the objectives of the Scheme, and in assessing challenges, if any, faced by the organization for achieving the standards fixed by Ministry.
The evaluation of the Scheme carried out by M/s CMRSD was based on the Explorative, Descriptive and Analytical-Research approach. Both secondary research and primary research were conducted as part of the evaluation.
The healthcare services provided by these Centres include integrated cancer treatment incorporating Ayurveda solutions, Ayurvedic treatment for conditions like bronchial asthma and rheumatoid arthritis, geriatric care through Regimental Therapy (Ilaj bil tadbeer) of Unani medicine, quality ophthalmologic care through Ayurveda and Homoeopathic care for disability.
Some of the centres have produced results in areas critical for modernization and development of AYUSH practices, practices like tissue culture and genetic mapping critical for studies of medicinal plants, creation of pharmacopial drugs atlas and pharmacopial monographs, standardizing of operating procedures specific drugs of Ayurveda and Siddha and establishing practices of documentation and treatment protocols for specific disease conditions.
A major finding was that through the innovative and creative projects taken up by these Centres, they not only promoted AYUSH systems, but also provided health care at quality hospitals having NABH accreditation. These CoEs have also succeeded in conducting Clinical Research for various diseases, Drug standardization, upgrading Quality Testing Laboratory and conducting research on medicinal plants. They also reached out to the public by developing IEC materials for dissemination of services. Further, they promoted Scientific Manufacturing of ASU drugs.
The study further observed that all the institutions given financial assistance under the scheme are of repute, financially sound, implementing the scheme as per the norms and objectives of the scheme and are serving the public well.
The distribution of CoEs studied covers the States of Telangana (Hyderabad) – 1, Karnataka (Bangalore) – 1, Kerala (Kottakal, Thrissur-2, Ernakulum) – 4, Tamil Nadu (Chennai, Coimbatore and Thanjavur) – 3, Uttarakhand (Almora) – 1, Uttar Pradesh (Saharanpur) – 1, West Bengal (Kolkata and Durgapur) – 2, Himachal Pradesh (Mandi and Kangra) – 2, Madhya Pradesh (Bhopal) – 1 and Maharashtra (Pune and Mumbai) – 2.
The geographic coverage analysis of the CoEs indicated that the CoEs are spread out across the country and that the impact of the projects is being felt in their regions as well as across the country. Further, majority of the CoEs informed that they didn’t face any issue in achieving the standard fixed by the Ministry.
The study found that beds are reserved for EWS patients in all the hospitals where IPD facility is available. Thus the CoEs are making a notable contribution in supporting the healthcare needs of the weaker sections. OPD data of CoEs reflects that more than 3 lakhs patients every year are being treated and are availing the specialist services in these centres.
More than 30 thousand IPD bed occupancy every year are reported by the CoE hospitals. The study observed that most of the OPD and IPD patients are satisfied with the treatment being provided by the CoEs and with the facilities available in the centre.
Study observed that the efforts made by the CoEs in terms of research projects and research paper publication (44 in numbers) in national and international journals are notable. Research projects are being done and from the research projects papers are being published in the research journals. Further, about 2000 raw materials standardization efforts have been completed by the CoEs.
The study has noted that I.T. needs to be inducted more rigorously at these Centres. Presently, most of the CoEs (16 in number) didn’t use software for management of database.
The study suggested orientation cum review meetings (annually) coordinated by AYUSH Ministry to address all the mplementation issues as well support/ guidance in documentation (online/ offline) and achieving the scheme objectives/ standards. Another recommendation related to information of CoE on the respective websites.
It was observed that very few organizations have uploaded the information of CoE on their website. It would be ideal if all the grantee organizations to design a dedicated page (in their website) or a website for CoE. It was also recommended that in order to expand the ambit of the scheme and create awareness, ‘success stories’ of the CoEs in terms of significant achievement need to be publicized widely.
This may be done by circulating these stories by making short films based on the ‘before-and-after’ scenarios. Such success stories will inspire other organizations to be more experimental as well as motivate them to achieve the deliverables in time.
The findings were presented by M/s CMRSD to a panel of senior functionaries of the Ministry of AYUSH, chaired by Vaidya Rajesh Kotecha, Secretary to Government of India. Encouraged by the findings, the panel decided to explore the feasibility of the CoE Scheme and of expanding its scope. (Source - PIB)
विश्व की प्राचीनतम चिकित्सा प्रणाली आयुर्वेद में असाध्य-से-असाध्य बीमारियों को ठीक करने की क्षमता निहित है. इसका प्रमाण समय - समय पर मिलता रहता है. ऐसे ही दो मामले फिर सामने आये हैं जिसे पद्मश्री वैद्य बालेंदु प्रकाश और वैद्या रूचि शर्मा ने सोशल मीडिया पर साझा किया है. इसमें एक मामला एक्यूट पैन्क्रियाटाइटिस का है तो दूसरा मामला इनफर्टिलिटी और ट्यूब ब्लॉक से संबंधित है. दोनों ही मामलों में आयुर्वेद चिकित्सा पद्धति की मदद से उल्लेखनीय सफलता और रोगी के रोग निदान में मदद मिली.
एक्यूट पैन्क्रियाटाइटिस का पहला मामला दस साल के एक बच्चे की है जिसका पहले से इलाज चल रहा था. लेकिन वैद्य बालेंदु प्रकाश की देखरेख में हुए आयुर्वेदिक प्रोटोकॉल के अंतर्गत हुई चिकित्सा से उसके स्वास्थ्य में बहुत सुधार हुआ. वैद्य बालेंदु प्रकाश ने प्रमाणिकता की जांच के लिए इस केस स्टडी को सोशल मीडिया पर साझा करते हुए मास्टर अर्चित अमेय लखीते (रोगी) के विवरण को भी साझा किया है ताकि शंका - आशंका की स्थिति में क्रॉसचेक भी किया जा सके.
(यह भी पढ़े ► क्रॉनिक किडनी डिजीज में आयुर्वेद का कमाल, पढ़िए वैद्य अनुज जैन की केस स्टडी)
एक्यूट पैन्क्रियाटाइटिस के इस केस स्टडी की जानकारी साझा करते हुए वैद्य बालेंदु प्रकाश लिखते हैं -
Ten-year-old boy from #Pune, #Maharashtra, diagnosed for #RecurringAcutePancreatitis in October 2014 at Deenanath Mangeshkar Hospital & Research Center in #Pune. He had three attacks and three emergency hospitalizations prior to start ayurvedic treatment protocol under Padama Shri Vaidya Balendu Prakash.
He left #Padaav after completing his first twenty one days indoor treatment with happy note about his well being.
Master Archit Amey Likhite could be contacted at:
Email: amey.[email protected]
दूसरे एक केस स्टडी में वैद्या रुचि शर्मा भारद्वाज इनफर्टिलिटी और ट्यूब ब्लॉक के एक मामले के बारे में जानकारी देते हुए बताती हैं कि कैसे आयुर्वेद चिकित्सा से महज दो महीने के आयुर्वेदिक उपचार से ही सकरात्मक परिणाम सामने आये. गौरतलब है कि पहले इसी मामले में सर्जरी की सलाह दी गयी थी, लेकिन आयुर्वेद चिकित्सा से चमत्कारिक परिणाम सामने आये. इस संबंध में डॉ. रुचि ने आयुर्वेद चिकित्सा के पहले और आयुर्वेद चिकित्सा के बाद की दो रिपोर्ट भी संलग्न की है. इस रिपोर्ट को साझा करती हुए वैद्या रूचि लिखती हैं -
( यह भी पढ़े ► आयुर्वेद में गॉल ब्लैडर स्टोन का उपचार, पढ़िए डॉ.अभिषेक गुप्ता की केस स्टडी )
Another Remarkable Success acheived by Ayurveda in #Infertility and #Tubalblockage ...patient took treatment at #ActiveAyuLife only for 2 months and make a success Story ...Yes Ayurveda has potential to treat and solve issues that advised for Surgery only. Proud and Blessed with Ayurveda.
यह भी पढ़े ► बच्चे को आयुर्वेद ने सर्जरी से बचाया, पढ़िए वैद्य नम्रता कुलश्रेष्ठ की केस स्टडी
( खबर का स्रोत - सोशल मीडिया)