New York, Feb 22 (IANS) Acid reflux disease which also causes heartburn symptoms is linked with higher risks of various cancers of the larynx (or voice box) and esophagus, suggests new research.Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the esophagus, where it can cause tissue damage.Research indicates that this damage may put patients at risk of developing a type of cancer called esophageal adenocarcinoma.To provide additional insights concerning this link and potential links to other types of cancer, a team led by Christian Abnet of the National Cancer Institute, part of the US National Institutes of Health (NIH), examined information on 490,605 adults enrolled in the NIH-AARP Diet and Health Study.Using Medicare claims data, the investigators estimated that 24 per cent of participants had a history of GERD. Over the following 16 years after participants joined the study, 931 patients developed esophageal adenocarcinoma, 876 developed laryngeal squamous cell carcinoma, and 301 developed esophageal squamous cell carcinoma. People with GERD had about a two-times higher risk of developing each of these types of cancer, and the elevated risk was similar across groups categorised by sex, smoking status, and alcohol consumption, said the study published early online in CANCER, a peer-reviewed journal of the American Cancer Society."This study alone is not sufficient to result in specific actions by the public. Additional research is needed to replicate these findings and establish GERD as a risk factor for cancer and other diseases," said Abnet. "Future studies are needed to evaluate whether treatments aimed at GERD symptoms will alter the apparent risks."--IANSgb/bg
Stomach ache or abdominal pain can be cramped, achy, dull, sharp, or intermittent. The common causes of stomach ache include constipation, diarrhea, acid reflux, lactose intolerance, stress, gas, and bloating.
Nutritionist and Lifestyle Educator, Karishma Chawla shares tips on how to deal with different stomach aches and home remedies for it:
Constipation is caused by lack of dietary fiber, indulging in too many processed foods, dehydration, too much dairy, medications, lack of exercise or movement, lack of routine or a hurried morning, ignoring the urge to defecate, and stress plays a big role. Chronic constipation can lead to gas production, stomach bloating, and ache. Dietary interventions include consuming whole grains such as dalia, red rice poha, rajgira, and legumes fruits and veggies rich in fiber like dark green leafy veggies, pear, and papaya, drinking plenty of water and other fluids like starting the day with lemon water and consuming vegetable smoothies.
Lifestyle measures include slowing down the morning ritual, having a routine, set wake up and sleep time along with some yoga and stretches. Avoid refined foods, deep-fried foods, and high sugar foods. Can experiment with black salt, this may help to relieve gas and bloating and aid digestion. And garlic helps to relieve gas, constipation and treat the infection.
Also, Read► Constipation: Causes, Symptoms And Ayurvedic Treatment
This can be caused by a viral infection, drugs, food allergies, and food sensitivities to name a few. Management of diarrhea includes fluid balance with coconut water, buttermilk, salted rice kanji, lemon sugar salt beverage, or weak tea.
Individuals with lactose intolerance usually lack the enzyme lactase to digest the lactose in milk leading to stomach cramps and diarrhea. Avoiding milk is beneficial and can substitute milk with almond and coconut milk.
Gas and Bloating
This can be a result of food sensitivities, constipation or indigestion leading to abdominal pain. Manage this by dropping food irritants that cause gas, eating a diet high in fiber, adequate water, chewing food properly. One can also experiment with adding herbs such as turmeric that help to break down food and absorb nutrients and garlic that helps to relieve gas.
It is caused by low stomach acid, magnesium deficiency, certain foods, hiatus hernia, and eating food too quickly. Relief is found by avoiding foods such as citrus foods, alcohol, spicy foods, peppermint. Practice mindful eating, chew every mouthful 20-30 times, and can experiment with aloe juice in the morning and sauf and kala jeera water before meals to secrete stomach acid.
Also, Read► Hyperacidity: Causes, Symptoms And Ayurvedic Treatment
Stress can cause low stomach acid. People with low stomach acid typically experience frequent heartburn, acid reflux, burping, bloating, gas, and even nausea after eating. Home remedies include a glass of warm water and fresh lemon or lime. Squeeze a tablespoon of lemon juice into the water and drink before consuming anything else. You can also try adding 1 tablespoon of raw apple cider vinegar to an 8-ounce glass of warm water and drink it about 15-30 minutes before a meal. Drink this after meals if you experience heartburn.
Hyperacidity is the condition, in which the hydrochloric acid is secreted more that the normal amount in the stomach. According to Ayurveda, hyperacidity is termed as amlapitta. It is a condition where increase in amlaguna(sour taste) of pachak pitta(gastric juice) occurs. It is considered as Pitta Kaphapradhana Tridoshaj vyadhi. Mainly it is cause by faulty diet, irregular meals excessive spicy, salty and hot diet, excessive oily, bakery products, use of starch, stress.
WHEN TO SEE YOUR DOCTOR FOR HYPERACIDITY DISEASE?
Facing difficulty/pain in swallowing especially with solid foods/pills.
Heartburn symptoms - more/severe/frequent
Heartburn is causing to have nausea/vomiting
Unexplained weight loss accompanied by heartburn
Chronic cough, choking sensation/sense of a lump in throat.
OTC (Over The Counter)- antacid medications for more than two weeks.
Extreme stomach pain
Discomfort interferes with lifestyle/daily activities.
Chest pain accompanied by pain in the neck,jaw, arms, legs, shortness of breath, weakness, irregular use, sweating.
CAUSES AND RISK FACTORS-
It includes smoking ,eating large and heavy meals specially during bedtime.
Delayed stomach emptying
After meal lying back/bending over at waist.
Snacking close to bedtime
Eating certain foods, such as citrus, tomato, chocolate, onions, spicy foods/fatty foods.
Drinking certain beverages such as alcohol/carbonated drinks/coffee/tea.
Taking aspirin, ibuprofen, certain muscle relaxers/ blood pressure medications.
Have small frequent meals (keeps stomach from stretching & pushing food & acid upward)
Avoid trigger foods (chocolate, citrus fruits, peppermint, tomato products/fried, fatty or spicy foods, garlic and onions)
Cut back on alcohol/tea/coffee
Don’t eat before bedtime.
Prop up the head of your bed 6 to10 inches(helps gravity keep in stomach away from oesophagus)
Stop making delayed stomach emptying.
Avoid smoking and alcohol intake.
Eat meals at-least 2 to 3 hours before lying down, this will give food time to digest and get out of stomach
Time your meals
Drink more water
Beat stress by yoga, meditation & cultivating some hobbies.
Chew 2-3 tulsi leaves regularly.
Infusion of - coriander seeds(dhanyak)+sugar = twice a day
Water obtained from green fruit of coconut 100-150 ml to be taken twice a day
Powder of amla (3-6 gm) two times in a day with water.
Powder of saunf + sugar (twice a day).
Chewing fennel seeds after a food.
Use of buttermilk
Jaggery after meal
Apple cider vinegar
Cumin seeds(jeera) use- Ayurvedic medicine recommends cumin seeds.
WHAT TO AVOID?
Avoid heavy- spicy- sour-hot-too-much oily food.
Excessive/scanty too early or too late.
Avoid anxiety, worry, anger, etc.
Avoid alcohol and acidic foods.
Avoid aspirin and other NSAIDs.
Avoid drinking of water- before meal -after meal- night after heavy meal.
Don’t take anything in b/w meals except liquids.
Suppression of the natural urges.
WHAT TO EAT?
Light food/coconut water/articles having cooling properties.
Vegetables like- (white pumpkin-bitter gourd-leafy vegetables except methi.)
Wheat- old rice- barley-green gram- sugar candy-cucumber.
Fruits like gooseberry/dry grapes/black grapes/sweet lime/pomegranate/ fig/dry fig to be included in diet.
Take adequate amount of Fluids like -pomegranate juice/lemon juice/amla juice/sweet-lime juice/ medicated water with ushir(wala) or coriander seed/ warm water.
Dadimpak(sweet preparation made of pomegranate)
Moramla( jam made from amla)
Gulkand with milk
Apart from these, according to Ayurveda, adequate sleep and rest is also necessary. Practicing Yoga, Pranayam, Meditation and Exercise regularly to be considered in daily routine.
QUESTIONS AND ANSWERS -
Q.1) What are the best treatments available for acidity?
Ans- The best treatment options available for acidity is the regular intake of safe and effective medications that includes antacids, indigestion drugs. Ayurveda treatment found effective. With that, it also need to improve lifestyle and daily routine.
Q.2) What are the main acidity symptoms considered?
Ans- The major acidity symptoms include-
Heartburn, ulcers in stomach, nausea, constipation
Q.3) How to prevent acidity?
Ans.- There are few precautions which need to be followed if a patient is suffering from the acidity.
The precautions include:
Having less and frequent meals.
Regular walking and other physical activities.
Wear loose clothes- To avoid pressure on the abdomen.
Reduce the intake of food which may trigger he symptoms of acidity like citrus food, raw onions, milk, salt, chocolates, tea, coffee, alcohol, carbonated beverages, and other tobacco products.
Reduce / avoid the consumption of spicy / deep fried food items.
Q.4) What are the complications involved with acidity?
Ans.- If the acidity is not treated properly, then it may lead to become more severe and complicated which include-
Severe pain in the chest or abdomen fora long duration.
Difficulties/pain in swallowing the food.
Other problems related to the digestive system which leads to constipation.
Q.5) How problem of acidity causes in our body and what are its effect?
Ans.-When we feel hungry, our body require energy from food and so our stomach starts secreting an acid called HCL (hydrochloric acid) which is a strong acid. And if we kept empty stomach for long duration , then the secretion of HCL will increase due to which it leads to appear symptoms of acidity like burning sensation, chest pain, indigestion, headache, dizziness, fatigue etc.
Q.6) What is the difference between acidity and hyperacidity?
Ans.- Acidity is a common medical condition that can range in severity from mild to serious while hyperacidity considered more severe form of acidity that may also persist for long duration.
Q.7) What if acidity continue for longer duration?
Ans.- If acidity lasts for long duration, then you need to consult doctor immediate and go for proper diagnosis and treatment.
Q.8) Is heartburn in acidity leads to major heart disease?
Ans.- No,heartburn is very different from heart diseases. It mainly occurs due to increase HCL in stomach and pressure generated on stomach muscles.
Q.9) How to cure acidity naturally?
Ans.- The best way to cure acidity naturally is to have a glass of watermelon juice / coconut water / buttermilk,can take bananas, cucumber, yoghurt in diet. They are also considered instant relievers.
Q.10) Which diagnostic studies are used in the workup of acidity?
Ans.- Some laboratory tests like esophagram, endoscopy, pH monitoring, biopsy are mainly used.
Q.11) How Ayurveda treatment considered effective?
Ans.-Effective because it deals with the elimination of doshas mainly pitta and kapha.It works on the principle of shodhana and shamana in which after elimination of doshas ayurvedic medicines given to the patient including lifestyle improvement guidance's.
Beijing - Researchers have found that regular use of acid reflux drugs, known as proton pump inhibitors (PPIs), is linked to a heightened risk of developing type 2 diabetes.
And the longer these drugs are taken, the greater the risk seems to be, the findings, published in the journal Gut show, prompting the researchers to advise that people taking these drugs for two or more years should have regular blood glucose check-ups to screen for diabetes.
PPIs are used to treat acid reflux, peptic ulcers, and indigestion.
They are among the top 10 most commonly used drugs worldwide.
"Long-term use has been linked to an increased risk of bone fractures, chronic kidney disease, gut infections and stomach cancer," said study authors from the Seventh Affiliated Hospital in China.
In 2014, the global prevalence of type 2 diabetes was 8.5 per cent, and the researchers wanted to find out if the widespread use of PPIs and the high prevalence of diabetes might be linked.
They drew on information supplied by 204, 689 participants (176,050 women and 28,639 men) aged 25 to 75.
According to the researchers, participants were also asked whether they had used PPIs regularly in the preceding 2 years: regular use was defined as 2 or more times a week.
During the average tracking period of around 9 to 12 years across all three groups, 10,105 participants were diagnosed with type 2 diabetes.
After taking account of potentially influential factors, including high blood pressure, high cholesterol, physical inactivity and use of other medication, those who regularly used PPIs were 24 per cent more likely to develop type 2 diabetes than those who didn't.
And the longer these drugs were taken, the greater was the risk of developing diabetes: use for up to 2 years was associated with a five per cent increased risk; use for more than 2 years was associated with a 26 per cent increased risk.
Further analysis showed that diabetes risk among PPI users wasn't affected by sex, age, family history of diabetes, smoking, alcohol intake, diet, physical activity, high cholesterol or regular use of anti-inflammatory drugs.
But it was higher among participants who weren't overweight or who had normal blood pressure.
For comparison, the researchers also looked at the potential impact of H2 blockers, another type of drug used to curb excess stomach acid production.
Regular use of these drugs was associated with a 14 per cent increased risk. Similarly, longer-term use was associated with a higher risk while longer time since stopping was associated with a lower risk, the study noted.
Washington, July 13 (IANS) In a major study, the researchers have showed that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells.The study, published in Developmental Cell, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells. Ferroptosis is an iron-dependent type of cell death that was discovered in recent years and has become a focal point for disease research as it is closely related to many disease processes."If you could deliver DGLA precisely to a cancer cell, it could promote ferroptosis and lead to tumour cell death," said study author Jennifer Watts from Washington State University in the US."Also, just knowing that this fat promotes ferroptosis might also affect how we think about conditions such as kidney disease and neurodegeneration where we want to prevent this type of cell death," Watts added.The research team revealed that DGLA is a polyunsaturated fatty acid found in small amounts in the human body, though rarely in the human diet. Compared to other fatty acids, such as those found in fish oil, DGLA is relatively understudied. Watts has been researching dietary fats including DGLA for nearly twenty years, using the nematode 'Caenorhabditis elegans' as an animal model.A microscopic worm, C. elegans is often used in molecular research because it is transparent and allows scientists to easily study cell-level activity in a whole animal over its relatively short lifespan. Results found in the C. elegans cells are also often transferable to human cells. The research team discovered that feeding nematodes a diet of DGLA-laden bacteria killed all the germ cells in the worms as well as the stem cells that make the germ cells. The way the cells died carried many signs of ferroptosis.To see if the results would translate to human cells, Watts team collaborated with Scott Dixon of Stanford University, who has been studying ferroptosis and its potential for battling cancer for many years. Taking what they had learned from the nematode work, the researchers showed that DGLA could induce ferroptosis in human cancer cells.They also found interaction with another fatty acid class, called an ether lipid, that had a protective effect against DGLA. When they took out the ether lipids, the cells died faster in the presence of DGLA.--IANSbu/pgh
Wuhan, May 19 (IANS) Wuhan, the capital of China's Hubei province where the COVID-19 pandemic originated last December, has conducted more than 1 million nucleic acid tests over the past week and recorded a significant drop in the incidence of asymptomatic cases, official media reported Tuesday.The number of asymptomatic patients who tested positive for the virus fell to 46 people per million tested from 660 per million in April, Efe news quoted the state-run daily Global Times newspaper as saying.This result suggests, according to local authorities, that the epidemic control situation has improved and that asymptomatics have low infectivity.The Global Times added that an antibody spot check of 11,000 people in April showed that 5 per cent had antibodies to the virus, which when extrapolated to the city's 11 million inhabitants could mean that some 500,000 Wuhan citizens had contracted the virus at some point.The state-run newspaper points out that, although the study was the initiative of the authorities, the results were not published by official sources, according to which more than 50,000 confirmed cases and 3,869 deaths have occurred in that city, the capital of the central province of Hubei.Wuhan is currently engaged in a mass-testing campaign for coronavirus, carried out free of charge, which should end on May 25.However, the deputy director of the pathogen biology department at Wuhan University, Yang Zhanqiu, said that the testing criteria vary in different districts of the city: for example, in some, both nucleic acid tests and antibody tests are performed while in others only the first test is carried out.This new campaign, according to the university professor, focuses on specific population groups such as the elderly and young people, as well as the city's residents who don't have stable jobs.These demographic sections had not been part of the previous rounds of testing, which focused on preparing the city to return to work and production.During the earlier campaigns, Wuhan focused on testing health and public transport workers, teachers, officials working in public places, caregivers and nursing home staff.The city authorities' decision to conduct mass tests for COVID-19 came after an infection was reported on May 9 - followed by another five the next day - which ended a 35-day streak with no coronavirus infections, according to official data. --IANSksk/