logo
  • AYURVEDA

    Medicine
  • DOCTOR

    e-Consult
  • Health Feed
  • AYURVEDA

    Clinics
  • NIROG FOR

    Doctors

CART

Your Cart

×

Empty-cart
Your Cart is Empty

Checkout

LOG IN | SIGN UP

  • All Medicine
  • Brand
    • VASU
    • SKM Siddha & Ayurveda
    • Gufic
    • Solumilks
    • Depson Herbals
    • Shree Vishwavati
    • NirogEssentials
    • Kerala Ayurveda
    • AIMIL
    • Innoveda
    • SN Herbals
    • Vyas
    • Dhootpapeshwar
    • Multani
    • Baidhyanath
    • Charak
    • Himalaya
    • Vaidyaratnam
    • Kottakkal
    • Seva Sadan
    • Sandu Pharmaceuticals
    • Arya Vaidya Pharmacy
    • Kairali
    • Alarsin
    • Organic India
    • Zandu
    • Unjha
    • Nirogam
    • Sri Sri Tattva
    • Nidco
    • Dr Bhargav's Amazing Herbals
    • Arjun Healthcare
    • Eternitive Herbals
    • Nagarjuna
    • Maharshi Ayurveda
    • Dr JRK Siddha
    • SG Phyto Pharma
    • Dabur
    • Bhardwaj Pharmaceutical Works
  • Classical Medicine
    • Bhasma
    • Choorna / Churna
    • Guggulu
    • Kupipakwa Rasayan
    • Loha / Mandoor
    • Parpati
    • Pishti
    • Rasakalpa
    • Suvarna Kalp - Gold (Premium)
    • Suvarna Kalp - Gold (Standard)
    • Avleh / Pak / Khand
    • Satva
    • Suvarna Kalp (Gold)
    • Avaleha / Khand / Pak
    • Ghrita
    • Oil / Tail
    • Kshara
    • Arishta / Arishtam
    • Asava / Asavam
    • Avleh / Khand / Pak
    • Bhasma / Pishti
    • Ark
    • Avaleha / Khand
    • Asava / Arishta
    • Gulika / Tablet / Vati
    • Proprietory
    • Kashayam / Kwatha
    • Kashayam Tablet
    • Gel Capsules
    • Lehyam / Rasayana
    • Taila
    • Capsule
    • Choorna / Churna Tablet
    • Ghrita Ointment
    • Kashayam Choornam
    • Khand / Pak
    • Granules
    • Aristha
    • Kadha/Kwatha
  • Patented Medicine
    • Ointment
    • Syrup
    • Capsule
    • Cream / Ointment
    • Gel
    • Nasal Drop
    • Oil
    • Tooth paste
    • Tooth powder
    • Churna / Powder
    • Cream
    • Lozenges
    • Toffees
    • Cleanser
    • Cosmetic
    • Face Pack
    • Shampoo
    • Soap
    • Balm
    • Eye Drop
    • Honey
    • Spray
    • Heena
    • Granules
    • Lehyam / Rasayana
    • Juice
    • Jaggery
    • Saffron
    • Tablet
    • Gulkand
    • Drops
    • Herbal Tea
    • Kanji
    • Lapam
    • Lotion
    • Gold
    • Potali
    • Hand Sanitizer
    • Mask
    • Capsules
    • Thermometer
    • Special Product
  • Featured Products
    • Diabe 250
    • Glycogeme
    • Hyna Cream
Menu
  • Brand
    • VASU
    • SKM Siddha & Ayurveda
    • Gufic
    • Solumilks
    • Depson Herbals
    • Shree Vishwavati
    • NirogEssentials
    • Kerala Ayurveda
    • AIMIL
    • Innoveda
    • SN Herbals
    • Vyas
    • Dhootpapeshwar
    • Multani
    • Baidhyanath
    • Charak
    • Himalaya
    • Vaidyaratnam
    • Kottakkal
    • Seva Sadan
    • Sandu Pharmaceuticals
    • Arya Vaidya Pharmacy
    • Kairali
    • Alarsin
    • Organic India
    • Zandu
    • Unjha
    • Nirogam
    • Sri Sri Tattva
    • Nidco
    • Dr Bhargav's Amazing Herbals
    • Arjun Healthcare
    • Eternitive Herbals
    • Nagarjuna
    • Maharshi Ayurveda
    • Dr JRK Siddha
    • SG Phyto Pharma
    • Dabur
    • Bhardwaj Pharmaceutical Works
  • Classical Medicine
    • Bhasma
    • Choorna / Churna
    • Guggulu
    • Kupipakwa Rasayan
    • Loha / Mandoor
    • Parpati
    • Pishti
    • Rasakalpa
    • Suvarna Kalp - Gold (Premium)
    • Suvarna Kalp - Gold (Standard)
    • Avleh / Pak / Khand
    • Satva
    • Suvarna Kalp (Gold)
    • Avaleha / Khand / Pak
    • Ghrita
    • Oil / Tail
    • Kshara
    • Arishta / Arishtam
    • Asava / Asavam
    • Avleh / Khand / Pak
    • Bhasma / Pishti
    • Ark
    • Avaleha / Khand
    • Asava / Arishta
    • Gulika / Tablet / Vati
    • Proprietory
    • Kashayam / Kwatha
    • Kashayam Tablet
    • Gel Capsules
    • Lehyam / Rasayana
    • Taila
    • Capsule
    • Choorna / Churna Tablet
    • Ghrita Ointment
    • Kashayam Choornam
    • Khand / Pak
    • Granules
    • Aristha
    • Kadha/Kwatha
  • Patented Medicine
    • Ointment
    • Syrup
    • Capsule
    • Cream / Ointment
    • Gel
    • Nasal Drop
    • Oil
    • Tooth paste
    • Tooth powder
    • Churna / Powder
    • Cream
    • Lozenges
    • Toffees
    • Cleanser
    • Cosmetic
    • Face Pack
    • Shampoo
    • Soap
    • Balm
    • Eye Drop
    • Honey
    • Spray
    • Heena
    • Granules
    • Lehyam / Rasayana
    • Juice
    • Jaggery
    • Saffron
    • Tablet
    • Gulkand
    • Drops
    • Herbal Tea
    • Kanji
    • Lapam
    • Lotion
    • Gold
    • Potali
    • Hand Sanitizer
    • Mask
    • Capsules
    • Thermometer
    • Special Product
   हिंदी ब्लॉग
  • All
    • Nirog Health Tips
    • Herbs
    • Interviews
    • Events and News
    • CoronaVirus Updates
    • Vaidya Corner
    • Diseases
    • Yoga and Fitness
    • Research
  • Ayurveda News
  • Health News
  • Food and Nutrition
  • Video Gallery
  • Photo Gallery
blog head ads
Home Blogs Research Some BP drugs linked to greater risk of heart failure

Some BP drugs linked to greater risk of heart failure

By NS Desk| Research| posted on :   26-Jul-2020

  • Share

New York - Researchers have found that L-type calcium channel blockers (LCCBs) -- the most widely used drugs for treating hypertension -- may harm the heart as much as help it.

The study found that in rats and human cells in vitro, LCCBs cause changes in blood vessels -- known as vascular remodelling -- that reduce blood flow and increase pressure.

Examining epidemiological data, the team also found that LCCBs are associated with a greater risk of heart failure.The findings, published in the journal Proceedings of the National Academy of Sciences, suggest that care should be taken when prescribing these drugs to patients, particularly older adults and those with advanced hypertension.

"L-type calcium channel blockers are one of the most widely prescribed drugs to treat hypertension, yet we have found that these drugs may cause the same type of damage they are intended to prevent," said study researcher Mohamed Trebak from Penn State University in the US.

Trebak explained that vascular smooth muscle cells (VSMCs) make up the walls of blood vessels, where they help the vessels to control blood flow by contracting and relaxing. This activity is regulated by the concentration of calcium within the cells.

VSMCs contain numerous calcium-permeable channels to control this calcium concentration. Under conditions of hypertension, these channels allow too much calcium to enter VSMCs, which triggers the cells to undergo physiological changes, known as "remodelling," and to divide and proliferate.AThese remodelled, proliferative cells cause blood vessel walls to thicken and stiffen and blood pressure to rise.

"L-type calcium channel blockers were created to prevent this from happening. Yet, we found that these drugs also simultaneously cause remodelling and proliferation of VSMCs through another mechanism," Trebak added.

To investigate the specific mechanisms by which LCCBs affect VSMCs, the research team used optical, electrophysiological and molecular tools to examine smooth muscle cells in vitro and in rats.

The team found that calcium entry into VSMCs is mediated by stromal-interacting molecule (STIM) proteins activating ORAI calcium channels and that chronic exposure to LCCBs causes these STIM proteins to become overactive, which triggers VSMCs to proliferate.

Additionally, the researchers examined epidemiological data and found that incidences of heart failure were significantly higher in hypertensive patients treated with LCCBs than in hypertensive patients treated with other types of hypertension medications.

"Treatment with LCCBs is clinically associated with an elevated incidence of heart failure, which prompts a careful examination of the use of LCCBs during chronic hypertension where vascular remodelling is evident," said Trebak. (agency)

Tags

bp drugs heart failure

NS Desk

Are you an Ayurveda doctor? Download our App from Google PlayStore now!

Download NirogStreet App for Ayurveda Doctors. Discuss cases with other doctors, share insights and experiences, read research papers and case studies. Get Free Consultation 9625991603 | 9625991607 | 8595299366

Read the Next

view all

S.Korea reports 389 more Covid cases

Seoul, Jan 18 (IANS) South Korea reported 389 more Covid-19 cases on Monday, raising the total number of infections to 72,729.The daily caseload fell below 400 in 54 days sinc...

Gurugram: Over 4,500 health workers to get vaccine on Monday

Gurugram, Jan 18 (IANS) The district health department is all prepared to stage the second round of Covid-19 vaccination drive in Gurugram on Monday.According to the health of...

Chinese mainland reports 109 Covid-19 cases (Ld)

Beijing, Jan 18 (IANS) The Chinese mainland has reported 109 new confirmed Covid-19 cases, of which 93 were locally transmitted and 16 arrived from outside the mainland, the N...

India's low streak continues with below 20K cases

New Delhi, Jan 18 (IANS) With 13,788 new coronavirus infections reported in the last 24 hours, India on Monday continued with its low streak of single-day cases, posting an ov...

Subscribe to our Newsletters
ads

Related Stories

Even one alcoholic drink everyday may up atrial fibrillation risk

Discrimination ups anxiety risk regardless of genetics

Metformin may reduce death risk in Covid patients with diabetes

DNA test can identify pneumonia in patients with severe Covid

Smoking linked to higher risk of subarachnoid hemorrhage

Health Talks

मानसिक तनाव से कैसे बचें?

रोग प्रतिरोधक क्षमता बढ़ाने के लिए बच्चों को स्वर्णप्राशन देना जरूरी

पिज्जा, पास्ता खाकर भी आयुर्वेद की मदद से अपने आप को ऐसे रखे स्वस्थ्य !

ब्लड में बढ़ते क्रिएटिनिन की रोकथाम के लिए आयुर्वेदिक उपाय

मोटापा कम करने का दिमागी खेल

×
  • Login
  • Guest Signup
Login with OTP
Forgot Password ?

Signup as a Doctor / Student?

please accept the terms & conditions

Next Are you a Doctor ?

Enter OTP

Resend OTP
previous-iconBack

Reset Password

Verify your number

Next

Enter OTP

Resend OTP
previous-iconBack

NirogStreet is a unique concept in the Ayurveda healthcare ecosystem. It was founded in June 2016. We are an impact organization striving to make Ayurveda the first call of treatment for people. Our technology-driven platform provides access to authentic Ayurveda doctors on a global scale.

Explore
  • About Us
  • Buy Medicine
  • Book a Doctor
  • Blogs
  • Contact Us
  • Ask a Question
  • For Doctors
  • Terms of Service
  • Privacy Policy
  • Cancellation Policy
Download app
Connect with us

Copyright © 2020 NirogStreet All Rights Reserved