New York - Muscular weakness is known to be associated with Type 2 diabetes and researchers now report that hand grip can help doctors perform time-efficient screening tool for diabetes.
Healthcare practitioners can use assessment of normalised grip strength to routinely screen for Type 2 diabetes in apparently healthy adults, according to a new study in the American Journal of Preventive Medicine.
The current study was able to identify consistent grip strength cut points relative to body weight, gender, and age group in a large nationally representative sample of participants pre-screened for conditions such as hypertension.
"Diagnosing this disease in its early stages is becoming increasingly more important for preventing complications caused by blood vessel damage associated with diabetes," said lead researcher Elise C Brown from Department of Public and Environmental Wellness, Oakland University, Rochester, Maryland.
The study identifies the levels of handgrip strength/weakness that correlate with Type 2 Diabetes in otherwise healthy men and women, according to their body weights and ages.
"Healthcare providers now have a reliable test to detect it early before such complications set in," Brown added.
Type 2 diabetes is asymptomatic in its initial stages, and a prompt diagnosis can prevent or delay vascular complications such as neuropathy, retinopathy and nephropathy.
For the study, researchers analysed data to establish normalized grip strength (grip strength relative to body weight) cut points for diabetes risk.
For example, the cut point for women aged 50-80 years is 0.49.
This means that if a 60-year old woman's combined grip strength from left and right hands was 43 kg, and her body weight was 90 kg, her normalized grip strength would be 0.478.
Since this value is less than 0.49, this indicates that she is at increased risk for diabetes and further screening is warranted.
"Given the low cost, minimal training requirement and quickness of the assessment, the use of the normalized grip strength cut points in this paper could be used in routine health screenings to identify at-risk patients and improve diagnosis and outcomes," explained Dr Brown.
London. Researchers have revealed that having genetically higher testosterone levels increases the risk of metabolic diseases such as type 2 diabetes in women, while reducing the risk in men.
Higher testosterone levels also increase the risks of breast and endometrial cancers in women, and prostate cancer in men, according to the study published in the journal Nature Medicine.
Despite finding a strong genetic component to circulating testosterone levels in men and women, the authors found that the genetic factors involved were very different between the sexes.
"Our findings provide unique insights into the disease impacts of testosterone. In particular they emphasise the importance of considering men and women separately in studies, as we saw opposite effects for testosterone on diabetes," said study lead author Katherine Ruth from University of Exeter in UK.
For the findings, the research team used genome wide association studies (GWAS) in 4,25,097 UK Biobank participants to identify 2,571 genetic variations associated with differences in the levels of the sex hormone testosterone and its binding protein sex-hormone binding globulin (SHGB).
The researchers verified their genetic analyses in additional studies, including the EPIC-Norfolk study and Twins UK, and found a high level of agreement with their results in UK Biobank.
The team next used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to understand whether known associations between testosterone levels and disease are causal rather than correlative.
They found that in women, genetically higher testosterone increases the risks of type 2 diabetes by 37 per cent, and polycystic ovary syndrome (PCOS) by 51 per cent.
However, they also found that having higher testosterone levels reduces T2D risk in men by 14 per cent.
Additionally, they found that genetically higher testosterone levels increased the risks of breast and endometrial cancers in women, and prostate cancer in men.
"Our findings that genetically higher testosterone levels increase the risk of PCOS in women is important in understanding the role of testosterone in the origin of this common disorder, rather than simply being a consequence of this condition," said study researcher John Perry from University of Cambridge.
Diabetes Drug Linked To Increased Risk Of Heart Problems
New York, Feb 6 (IANS). Researchers have found that rosiglitazone -- a drug used to treat type 2 diabetes -- is associated with an increased risk of heart problems, especially heart failure.
Rosiglitazone belongs to a class of drugs called thiazolidinediones. It helps control blood sugar levels in patients with type 2 diabetes, but it can also increase the risk of serious heart problems, said the study, published in the journal The BMJ.
"Our study suggests that when evaluating drug safety and performing meta-analyses focused on safety, individual patient level data (IPD) might be necessary to accurately classify all adverse events," said the study researchers
"By including these data in research, patients, clinicians, and researchers would be able to make more informed decisions about the safety of interventions," they added.
Since 2007, studies have reported conflicting findings about whether rosiglitazone increases the risk of heart attacks.
But these studies didn't have access to the raw data from clinical trials and mostly relied on summary level data (e.g. results reported in publications and clinical trial registries), which are not as reliable when estimating the true safety profile of drugs.
Recent efforts by Pharmaceutical company GlaxoSmithKline (GSK) - the maker of rosiglitazone - to make IPD available to external investigators, prompted a team of researchers to re-analyse the data and clarify some of the uncertainties about rosiglitazone's cardiovascular risk.
They analysed the results of more than 130 trials involving over 48,000 adult patients that compared rosiglitazone with any control for at least 24 weeks.
IPD were available for 33 trials, which included 21156 patients; the remaining trials only had summary level data available.
When the researchers analysed the IPD from trials made available by GSK, they found rosiglitazone was associated with a 33 per cent increased risk of a composite cardiovascular event (heart attack, heart failure, cardiovascular and non-cardiovascular related death) compared with controls.
This was estimated from the 274 events among 11,837 rosiglitazone patients and 219 events among 9,319 control patients.
These findings highlight the potential for different results derived from different data sources, and demonstrate the need for greater clinical trial transparency and data sharing to accurately assess the safety of drugs, the researchers added.
Less meat, more plant-based diet cuts heart disease risk
Toronto, Jan 8 (IANS) With more people with diabetes and pre-diabetes looking for strategies to help control blood sugar, a new study suggests that Ketone Monoester Drinks - a new food supplement - may help to it.
"There is mounting evidence that a low carbohydrate ketogenic diet is very effective in controlling blood sugar and even reversing Type 2 Diabetes," said study lead author Jonathan Little, Associate Professor at the University of British Columbia in Canada.
"We wanted to know what would happen if artificial Ketones were given to those with obesity and at risk for Type 2 Diabetes but who haven't been dieting," Little added.
Type 2 Diabetes is a disease whereby the body is unable to control the level of sugar in the blood because defects in the functioning of a hormone called insulin.
"It's a disease that's becoming alarmingly common in Canada and approaching what many would consider epidemic levels," Little said.
"While Type 2 Diabetes can be controlled with medications or injectable insulin, many people are looking to options that don't require taking pills every day or that are less invasive," he added.
According to the study published in the American Journal of Clinical Nutrition, Ketone supplements are proving fertile ground for research into Type 2 Diabetes because Ketones are the natural fuel source of the body when it's in ketosis - the metabolic byproduct of consuming a low carbohydrate, ketogenic diet.
To test the idea, the research team asked 15 people to consume a Ketone Drink after fasting overnight.
After 30 minutes, they were then asked to drink a fluid containing 75 grams of sugar while blood samples were taken.
"It turns out that the Ketone Drink seemed to launch participants into a sort of Pseudo-Ketogenic state where they were better able to control their blood sugar levels with no changes to their insulin," Little explained.
"It demonstrates that these supplements may have real potential as a valuable tool for those with Type 2 Diabetes," he said.
"There are a number of problems that we still have to work out, including the fact that we still don't know what the long-term effects of consuming ketones are," he added.
"But for those that aren't able to follow a strict and challenging ketogenic diet or for those that are looking for a new way to control blood sugars, this may be another strategy in helping to manage Type 2 Diabetes," Little concluded.
You are not alone in this world who are suffering from diabetes there are trillions of people who have the same problem. Surprisingly, many people double the risk of having other diseases due to it, such as mental disorder, health disease, depression, or cardiac problems. even so, in some cases, it can be preventable or reversed.
Taking preventive measures or controlling diabetes does not mean cutting the carbs and sugar in the food and commit you to the bland food. People suffering from diabetes have an equal nutritional need as everyone else. It means eating, tasty, healthy, and balanced fiber diet to boost energy and no cutting of special food. With healthy tips, you can again take pleasure in tasty food without feeling hungry.
What diet do you suppose to take in diabetes?
The meal planning starts with taking carbohydrate food, organic fat that are found in fruits, fresh vegetables, milk and in yogurt, and protein. However, there is a myth regarding carbs that it can increase the blood sugar level. The body needs it to convert into energy but having too much of it can raise your glucose level and cut it can lower the sugar level. That is why eating a balanced carb with fat and protein will help in maintaining body glucose range. Here are the foods that a diabetic person can take daily:
Fish: tuna and salmon are the fish that is rich in protein and it will keep you satisfied. fish also contains omega-3 fatty acid that will help in cooling inflammation. thousands of studies have shown that very inflammation can lead to or worsen diabetes. however, it is advised to eat baked, steamed, and broiled fish to get the effective result.
Green vegetables: spinach, soya-methi, broccoli, mustard leaves, bitter gourd, bottle gourd etc are vegetables, which is very useful for diabetes. people who take more than one green vegetable a day have a tendency to reduce the risk by 14%. these vegetables are rich in vitamin-k, magnesium, phosphorous, zinc, iron, and potassium.
Nuts: almond, walnut, pistachios, and cashews- the widespread tree nuts contain a fatty acid called alpha-linolenic that is polyunsaturated acid, antiviral, and anti-oxidants, vitamin-e, fiber, omega-3s. these nuts help in lowering the inflammation and can reverse the conditions of chronic diabetes.
Olive oil: this oil can reduce the 50% chance of occurring type-2 diabetes as compared to low-fat diet. it contains monounsaturated fats that is overall health promoting and antioxidants that protect the cells from damage.
Spices: eating 1gm to 6gm of cinnamon regularly for 40 days can curb the blood sugar by minimizing the insulin resistance. moreover, it also has the capability to cut cholesterol by 18% and sugar level by 24%.
The cure for diabetes lies on our natural diet, people just need to follow these diet instead of cutting carbs from food.
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Diabe 250: Manage Diabetes More Effectively Than Ever
We are well aware that our body is a combination of cells, veins, bone, muscles, tissues, etc each part contributes to the proper functioning of the body. However, have you ever noticed that if any part of the body does not work well, it also affects other part? For example,with if a person is suffering from liver disease, they may have a severe metabolic problem and this may lead to them developing a cardiac disease. The functionality of liver affects the digestive system, the metabolic property of the body and you may feel fatigued sometimes. The functions of our body parts are all inter-related and interdependent.The onset of any disease is not limited to only a particular part of the body, it definitely affects other body parts. hence, like another disease, diabetes also affects some major parts of our body. It varies from person to person though. In some people, it may affect their sexual life, for others it may cause hypertension, high blood pressure, obesity, depression, or thyroid disorders. Nowadays, diabetes is a major issue for a large number of people because it causes other ailments in the body and hampers other functionalities of the body. It is not the only disease to take care of but there are other diseases associated with it that might be surfacing without you being even slightly aware. Here are some other issues caused only because of diabetes that you should be concerned about:-Damage to the kidney Diabetes leads to high blood sugar level and it can cause improper functionality of the kidney. If the body does not control sugar for a prolonged time, it may cause failure of the kidney (renal failure). Moreover, if a person has high blood pressure and a family history of diabetes, they need to take care of their kidney at an extreme level. High blood pressureDiabetes tends to raise the risk of high blood pressure which has severe consequences on the body. Constant high blood pressure can itself create a lot of complications for any diabetic patient. It can lead to migraine, hemorrhage, stroke, and other such threats. Cholesterol and heart diseaseThe heart is the main organ that pumps blood in the body, but if the blood contains high sugar level, it may cause high cholesterol and other cardiovascular diseases. Basically, the high sugar level of the blood leads to fatty deposits around the heart wall that clog the blood vessels. When the blood vessels are clogged or constricted, it can lead to heart attack or stroke. This is threatening condition when a person has 15 years of diabetic history. Nerve diseasesIf blood vessels get narrowed from fatty deposits, it prevents the oxygen flow to the nerves. This can cause the neuropathic disease or may lead to nerve tissue damage. Without proper nourishment of the nerve, it may result in disorders such as inflammation, numbness in legs, arms, and fingers, pain due to neuropathic diabetes, sexual dysfunction, etc. AmputationDue to the narrowing of the blood vessels, circulation of blood in the lower portion of the body may not be optimal. Because of this, a person can suffer from bruises or lesions on their feet or leg and this will take a long time to heal because of diabetes that reduces the self-healing effect of the immune system. Moreover, if a person suffers nerve damage due to diabetes, it may result in amputation of leg or feet.In addition to all these, diabetes can also affect the reproductive health, especially during pregnancy, and lead to skin conditions as well. if you have diabetes or a pre-diabetic condition, it is best to consult the medical experts from time to time and manage your diabetes as per their guidelines in a strict manner. following a holistic lifestyle can also help you avert the risks wisely. by managing it well, you would be able to avoid the risks that are mentioned above. prevention is the best cure, as it is said. image reference: source/linkRead More >>> What is diabetes in Ayurveda?Control Diabetes with AyurvedaDoes eating high-calorie food cause diabetes?How to find you are suffering from Diabetes?What causes the insulin to malfunction?Why People Keep Suffering from Diabetes?Five best foods that Diabetic people should know aboutDiabe 250: Manage Diabetes More Effectively Than Ever